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Research and Practice in Thrombosis and Haemostasis
Scopus
ISSN 2475-0379 · Elsevier · 1.467 artikel di indeks
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Artikel Jurnal
Venous thromboembolism in patients with breast, ovarian, and uterine cancer. A comparative analysis from the Registro Informatizado Enfermedad TromboEmbólica registry
Background: The risk of recurrent venous thromboembolism (VTE) and bleeding during anticoagulation may vary by the cancer type. Objectives: We assessed outcomes during anticoagulation in women with breast, ovarian, or uterine cancer and VTE. Methods: We analyzed data from the Registro Informatizado…
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Artikel Jurnal
Tissue factor detection in mouse tissues by western blotting using commercial antibodies
Background: Tissue factor (TF) is a receptor for factor (F)VII/FVIIa and is essential for hemostasis. TF is expressed in a tissue-specific manner, with differing TF levels across tissues. TF expression is increased in a variety of diseases, so accurate measurement of TF protein levels is important…
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Urine-based point-of-care detection of direct oral anticoagulant activity in acute stroke—accuracy at anti-Xa thresholds relevant for intravenous thrombolysis
Background: Rapid assessment of direct oral anticoagulant (DOAC) activity is essential in acute ischemic stroke (AIS), particularly because intravenous thrombolysis (IVT) may be considered at anti-Xa levels ≤ 100 ng/mL. Laboratory drug-specific assays; however, are often limited by availability and…
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Artikel Jurnal
Health-related quality of life in adults with von Willebrand disease: results of the French real-life Willebrand study on health-related quality of life
Background: Hemorrhagic events in von Willebrand disease (VWD) impair patients’ physical health, daily functioning, and psychological/emotional well-being. While few studies have assessed health-related quality of life (HRQoL) in VWD, no prospective evaluation had been conducted in France…
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Artikel Jurnal
Assessing genetic risk factors for early-onset coronary artery disease in Iranians
Background: Coronary artery disease (CAD) is a leading cause of death worldwide. Evidence of genetic predisposition is derived mostly from studies of Europeans and East Asians. Objectives: To test selected variants for association with early-onset CAD. Methods: We performed a case-control study of…
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Artikel Jurnal
Venous thromboembolism prophylaxis in postacute care units: a health record review
Background: Venous thromboembolism (VTE), encompassing deep vein thrombosis (DVT) and pulmonary embolism (PE), is a major cause of vascular-related mortality. While VTE prophylaxis (VTEp) is well established in acute care settings, its value in postacute care units, such as transitional care units…
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Factor VIII in vitro bioequivalence of denecimig (Mim8) hemostatic effect by thrombin generation assays
Background: Denecimig (Mim8, Novo Nordisk A/S) is a next-generation bispecific antibody designed to mimic activated factor (F)VIII and restore hemostasis in persons with hemophilia A. The extent to which activated FVIII mimetics, such as denecimig and emicizumab, can correct clotting deficiency…
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Performance evaluation of 9 large language models in anticoagulation decision-making for nonvalvular atrial fibrillation
Background: Large language models (LLMs) are increasingly applied in clinical decision support, but their reliability in guiding anticoagulation management for nonvalvular atrial fibrillation (NVAF) remains unclear. Objectives: To systematically evaluate the performance of 9 widely used LLMs in…
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Artikel Jurnal
Country-level prediction of blood type distribution in hemophilia A in support of factor VIII consumption
Background: Hemophilia A is an inherited bleeding disorder resulting from a lack of factor (F)VIII. Patients with blood type O show faster decay in their FVIII pharmacokinetics and may require higher usage of factor concentrate. Although country-level blood type distribution among persons with…
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Artikel Jurnal
Distinct fibrin clot characteristics in individuals with severe obesity and metabolic liver disease: 2-year follow-up after bariatric surgery
Background: Obesity predisposes individuals to metabolic dysfunction–associated steatotic liver disease (MASLD), the hepatic manifestation of metabolic syndrome. Studies in mice suggest that fibrin deposition in adipose tissue and liver promotes obesity and MASLD, but whether similar mechanisms are…
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Dealing with heavy menstrual bleeding in very rare bleeding disorders: from a patient’s perspective
Data on heavy menstrual bleeding in women with very rare bleeding disorders, such as very rare coagulation factor deficiencies or severe inherited platelet disorders, are scarce. Heavy menstrual bleeding is a common health problem in premenopausal women, causing both physical and psychosocial…
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Aortotomy-induced acute mural thrombosis progresses to saccular aneurysm formation
Background: Current models of arterial thrombus frequently rely on chemical or mechanical injury and often cause total vessel occlusion, limiting their relevance as a model of early events. To address this, we developed a reproducible mouse model of mural thrombus induced by an aortotomy. Methods…
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Artikel Jurnal
Quantifying endothelial damage by digital droplet polymerase chain reaction (PCR) of endothelial cell-free DNA in COVID-19 patients
Background: COVID-19, caused by SARS-CoV-2, triggers severe systemic inflammation and multiple organ dysfunction. Microvascular complications, potentially arising from endothelial cell infection and/or immunothrombosis, play a central role in the disease's pathophysiology. Upon cell activation…
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Beyond a century of discovery: the global and persistent burden of underdiagnosis in von Willebrand disease
In February 2026, von Willebrand disease (VWD) will mark a century since its first description by Dr Erik Adolf von Willebrand. VWD is the most common inherited bleeding disorder and characterized predominantly by mucocutaneous bleeding. Despite remarkable advances in understanding its biology…
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Urine albumin-to-creatinine ratio and risks of incident arterial thromboembolism and pulmonary embolism among adults—a prospective cohort study
Background: It is well-established that reduced kidney function and large amounts of proteinuria are associated with thrombotic and embolic events. However, the relationship between urine albumin-to-creatinine ratio (UACR) and the risk of incident arterial thromboembolism (ATE) and pulmonary…
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Artikel Jurnal
Nationally representative estimates of health care burden of venous thromboembolism in hospitalized cancer patients
Background: Venous thromboembolism (VTE) is a frequent and often preventable cancer-related comorbidity. Objectives: This study evaluated national health care burden of patients hospitalized with cancer and VTE diagnoses. Methods: The 2021 Nationwide Inpatient Sample was used to generate nationally…
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