693 results
Showing 1–20 · 1.37 seconds · RSS
Scripta Medica
ISSN 2490-3329 · Medical Society of the Republic of Srpska, Banja Luka, University of Banja Luka. Faculty of Medicine · 693 articles in the index
-
Journal Article Full text
Gut microbiome and diabetes: Emerging perspectives in metabolic regulation
Diabetes mellitus type 2 (T2DM) is one of the fastest-growing metabolic disorders in the world. It is marked by insulin resistance, high blood sugar and high cholesterol levels. Recently, its prevalence has increased significantly, making it a major health issue globally. New evidence shows that…
-
Journal Article Full text
Infiltrative therapy of adipose vital micrografts in a metabolic and protective solution in Peyronie's disease: A case report in a pilot study
Peyronie's disease or induratio penis plastica, is characterised by fibrotic plaque formation within the tunica albuginea, leading to penile curvature and pain. Current minimally invasive treatments provide limited outcomes. Aim of the research was to explore the preliminary feasibility and…
-
Journal Article Full text
Phenotypic characteristics of patients with irritable bowel syndrome: Association between gastrointestinal symptoms and psychological factors: A pilot study
Background/Aim: Irritable bowel syndrome (IBS) is a heterogeneous functional gastrointestinal (GI) disorder frequently associated with psychological symptoms. Phenotypic characterisation of patients may improve understanding of the relationship between gastrointestinal and psychological dimensions…
-
Journal Article Full text
Intermittent fasting as a complementary strategy to manage type II diabetes and metabolic health: A review
As an alternative or supplement to traditional pharmaceutical treatments, intermittent fasting (IF) has become a viable dietary approach for the management of type 2 diabetes mellitus (T2DM). Improved insulin sensitivity and blood glucose management are the outcomes of various IF patterns, such as…
-
Journal Article Full text
Effects of different crosslinkers on the release levels of growth factors (TGF-ß, BMP and PDGF) from hydroxyapatite combined with secretomes
Background/Aim: Controlled release of growth factors is essential for bone regeneration, requiring biomaterials with high stability and osteoconductivity. Hydroxyapatite (HA) is biocompatible and osteoconductive but limited by weak mechanical strength and uncontrolled growth factor release. This…
-
Journal Article Full text
Hypolipidaemic effect of an immature pomelo (Citrus maxima) extract in a tyloxapol-induced hyperlipidaemia mouse model
Background/Aim: Pomelo extracts are rich in bioactive flavonoids and may regulate lipid metabolism. However, studies evaluating the lipid-lowering effects of immature pomelo derived from agricultural by-products remain limited in Vietnam. This study was conducted to investigate the hypolipidaemic…
-
Journal Article Full text
Predictive value of protein kinase C delta as a diagnostic biomarker for hepatocellular carcinoma in hepatitis C virus-related cirrhosis
Background/Aim: Hepatocellular carcinoma (HCC) is considered the 6th prevalent tumour and 3rd leading cause of cancer-associated mortality worldwide. Protein kinase C delta (PKCδ), released by liver cancer cells, has an effect in cell-proliferation and cancer formation, recommending PKCδ can serve…
-
Journal Article Full text
Retinoic acid delivery via ultraflexible nanovesicular system for the management of posterior segment ocular diseases
Background/Aim: Ophthalmic diseases, especially conditions of posterior segment of eye encompass a range of conditions affecting the vitreous, choroid and retina, resulting in both structural and functional deficiencies in the eye. This study aimed to formulate and evaluate ultraflexible…
-
Journal Article Full text
Development of a sprayable thermosensitive hydrogel containing rambutan (Nephelium lappaceum L) leaf extract for diabetic wound therapy
Background/Aim: Diabetic wounds are challenging to treat due to impaired healing processes. This study aimed to develop a sprayable thermosensitive hydrogel incorporating rambutan (Nephelium lappaceum L) leaf extract, known for its phytochemical wound healing potential. Methods: Rambutan leaves…
-
Journal Article Full text
Distribution of CD15+ and CD31+ cells in the oesophageal mucosa of children with eosinophilic oesophagitis across different age and sex groups
Background/Aim: Eosinophilic oesophagitis (EoE) is a chronic immune-mediated inflammatory disease of the oesophagus with a multifactorial nature. The prognosis and effectiveness of therapy for EoE largely depend on a detailed study of its pathogenetic mechanisms. To clarify the severity of the…
-
Journal Article Full text
Role of chrononutrition in modulating metabolic and cardiovascular health
Maintaining optimal cardiovascular and metabolic health depends on aligning dietary practices with the body's intrinsic circadian rhythms. Chrononutrition is a rapidly advancing research area that explores how the timing of food intake influences physiological health outcomes. Unlike conventional…
-
Journal Article Full text
Stem cell-based therapies combined with nano-biomaterials for nerve regeneration and repair
Nerve injuries, often resulting from trauma or degenerative diseases, pose significant challenges due to limited regenerative capacity of nervous system. Conventional treatments, including surgical nerve grafts, exhibit limitations such as donor site morbidity and limited functional recovery…
-
Journal Article Full text
Metabolic syndrome in lean versus obese polycystic ovarian syndrome (PCOS) phenotype
Background/Aim: Polycystic ovarian syndrome (PCOS) is the most common metabolic, hormonal and endocrinological condition. Compared to lean, obese PCOS women are more likely to experience infertility, irregular menstruation, acanthosis and hirsutism. Aim of this study was to investigate the…
-
Journal Article Full text
Silybin attenuates neurobehavioural impairments and secondary brain damage following traumatic brain injury in mice
Background/Aim: Traumatic brain injury (TBI) is a neurodegenerative disorder resulting in temporary or permanent impairment of cognitive, physical and psychosocial functions. Presently no treatment is available to overcome TBI. Flavonoids can be utilised for treatment of TBI due to their…
-
Journal Article Full text
Oral health-related quality of life and satisfaction following implant restoration after sinus floor augmentation: A prospective evaluation
Background/Aim: Alveolar ridge resorption and maxillary sinus pneumatization present significant challenges for implant rehabilitation. Although lateral window sinus floor augmentation (LWSFA) is a predictable surgical approach, patient-reported outcomes remain essential for evaluating treatment…
-
Journal Article Full text
Antifungal pharmacotherapy and hepatic safety: Mechanisms of drug-induced liver injury (DILI) and risk mitigation
The growing prevalence of invasive fungal infections (IFIs), especially among immunocompromised patients, has resulted in increased reliance on systemic antifungal therapies. Hepatotoxicity is still a serious clinical problem even with improvements in treatment results. This study consolidates the…
-
Journal Article Full text
Exploring the nutritional, medicinal and economic significance of Morchella esculenta: A comprehensive review
This overview summarises the nutritional profile, medicinal properties, economic significance and traditional uses of Morchella esculenta (Guchhi). It also highlights research gaps to guide future studies. Information from multiple sources was synthesised to explore the mushroom's nutritional…
-
Journal Article Full text
Navigating the storm: Understanding and managing depression during menopause in women
Depression has a prevalence of about 280-300 million individuals globally and is more prevalent in women than in men. Hormonal changes, vasomotor changes and psychosocial factors are linked with the high risk of depression during menopausal transition. Oestrogen also acts upon serotonergic…
-
Journal Article Full text
Geriatric diabetes care: Prescribing practices and drug utilisation at a teaching hospital
Background/Aim: Diabetes is increasingly recognised as a major health concern worldwide, affecting around 537 million adults and causing approximately 6.7 million deaths annually. In India alone, 74.9 million individuals had diabetes in 2021 and this figure could rise to 124.9 million by 2045…
-
Journal Article Full text
Green synthesis of silver nanoparticles using Euphorbia microsphaera: Tuning size and stability via precursor concentration
Background/Aim: The green synthesis of silver nanoparticles (AgNPs) by plant extracts provides an environmentally friendly alternative to traditional chemical methods. This study aimed to report the biosynthesis of AgNPs using Euphorbia microsphaera, a native plant of the Middle East and to…