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Microbiology Independent Research Journal
ISSN 2500-2236 · MicroMIR · 135 artikel di indeks
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Artikel Jurnal
Escherichia coli circulation among university students in Southwestern Nigeria: prevalence, resistance patterns, extended-spectrum β-lactamase production, and risk factors
INTRODUCTION: Antimicrobial resistance (AMR) remains a critical global health challenge and is increasingly reported in bacteria circulating among healthy young adults. University students constitute one of the key community groups in which antibiotic misuse and environmental exposures can drive…
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Artikel Jurnal
Composition and clinical significance of the oral microbiota in health and disease: focus on children and upper respiratory pathology
BACKGROUND: The oral microbiota is a complex, site-specific microbial ecosystem that develops from birth and contributes to oral homeostasis, immune maturation, and host – microbe interactions. Increasing evidence links oral dysbiosis not only to dental caries and periodontal disease but also to…
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Artikel Jurnal
Reverse vaccinology as a platform for antigen discovery: towards the development of an effective staphylococcal vaccine
BACKGROUND: Gram-positive cocci, particularly Staphylococcus aureus and Staphylococcus epidermidis , are common components of the human microbiota but can act as opportunistic pathogens, causing a wide range of infections. The increasing prevalence of antimicrobial resistance has highlighted the…
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Artikel Jurnal
Wastewater as a predictive resistome surveillance system: from genes to ecological risk
BACKGROUND: Wastewater resistome surveillance has emerged as a promising strategy for monitoring antimicrobial resistance (AMR) at the population level. However, translating complex environmental resistome datasets into operational indicators of resistance risk remains a major challenge because…
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Artikel Jurnal
Bacterial vaginosis in West Africa: prevalence, pathogenesis, diagnosis, and reproductive health implications
BACKGROUND: Bacterial vaginosis (BV) is a common vaginal dysbiosis characterized by loss of Lactobacillus -dominant communities and overgrowth of anaerobic bacteria. BV is highly prevalent in sub-Saharan Africa and is linked to adverse pregnancy outcomes and heightened susceptibility to sexually…
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Artikel Jurnal
Hepatic and primary mesenteric hydatid cysts in an endemic region: a three-case report with clinicopathological correlation and diagnostic implications
BACKGROUND: Cystic echinococcosis, caused by Echinococcus granulosus , remains a significant zoonotic infection in endemic regions. Although hepatic involvement is the most common presentation, rare extrahepatic intra-abdominal localizations, such as primary mesenteric hydatid cysts, pose…
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Artikel Jurnal
Phase 1 evaluation of UniFluVec: safety and reactogenicity of an intranasal universal influenza vector vaccine at two dose levels
BACKGROUND: UniFluVec is a live attenuated recombinant influenza vaccine candidate designed to enhance mucosal immunity and provide broad cross-protective responses after intranasal administration. This Phase 1 randomized, double-blind, placebo-controlled trial evaluated its safety and tolerability…
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Phenotypic and genotypic comparison of biofilm producers among carbapenem susceptible and resistant Klebsiella pneumoniae strains
About one third of all Gram-negative bacterial infections globally are caused by Klebsiella pneumoniae. These bacteria readily become drug resistant and form biofilms that significantly complicates treatment of infections. This study aimed to compare biofilm production in carbapenem-resistant (CR)…
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Онколитический потенциал вируса гриппа в терапии глиом
Глиобластома остается опухолью с одним из самых неблагоприятных прогнозов в клинической онкологии. На фоне недостаточной эффективности стандартных методов лечения активно развивается онколитическая виротерапия. Однако вирус гриппа все еще остается на периферии внимания. В данный обзор мы включили…
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Microbiological profile and antimicrobial resistance in ventriculoperitoneal shunt infections at a tertiary hospital in Central India
INTRODUCTION: Hydrocephalus is characterized by the abnormal accumulation of cerebrospinal fluid (CSF) within the brain, resulting in elevated intracranial pressure. A ventriculoperitoneal (VP) shunt diverts excess CSF to the peritoneal cavity to relieve this pressure. However, VP shunt placement…
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Chemical characterization of Dichrostachys cinerea extracts using GC-MS and column chromatography
BACKGROUND: Dichrostachys cinerea , a plant known for its extensive use in traditional medicine. OBJECTIVE: D. cinerea was analyzed to identify its bioactive compounds and to assess its therapeutic potential. METHODS: Using gas chromatography – mass spectrometry (GC-MS) and column chromatography…
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Priority pathogens of fungal and bacterial infections: development trends and impact on the epidemiological situation in the Russian Federation
OBJECTIVE OF THE STUDY: This review analyzes the epidemiological situation of fungal and bacterial infections in Russia, including the identification of priority pathogens based on WHO data, their geographic distribution, impact on various age or social groups, and infection severity. The analysis…
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Coexistence of imipenemase (IMP) and verona integron-encoded metallo-beta-lactamase (VIM) in gram-negative bacterial clinical isolates from Ouagadougou, Burkina Faso
INTRODUCTION: Escherichia coli , Pseudomonas aeruginosa , and Klebsiella oxytoca are among the most frequently isolated pathogens implicated in human disease in Burkina Faso. In addition, the emergence of carbapenem-resistant E. coli , P. aeruginosa , and K. oxytoca due to the production of IMP and…
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Приоритетные возбудители грибковых и бактериальных инфекций: тенденции развития и влияние на эпидемиологическую обстановку в РФ
ЦЕЛЬ ИССЛЕДОВАНИЯ: Данная обзорная статья анализирует эпидемиологическую ситуацию по грибковым и бактериальным инфекциям в России, включая идентификацию приоритетных возбудителей с учетом данных ВОЗ, их географическое распространение, влияние на различные возрастные и социальные группы, а также…
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The integration of artificial intelligence in microbiology labs: enhancing efficiency and accuracy
Artificial intelligence (AI) is reshaping microbiology laboratories by improving diagnostic accuracy, workflow efficiency, and the interpretation of increasingly complex datasets. Machine learning algorithms enhance microbial identification, particularly when applied to MALDI-TOF MS spectral…
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Клиническое исследование фазы 1 вакцины UniFluVec: оценка безопасности и реактогенности интраназальной универсальной векторной вакцины против гриппа при двух дозовых уровнях
ВВЕДЕНИЕ: UniFluVec — живая аттенуированная рекомбинантная вакцина против гриппа, разработанная для усиления мукозального иммунитета и формирования широкого перекрестного иммунного ответа при интраназальном введении. В данном рандомизированном двойном слепом плацебо-контролируемом клиническом…
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Oncolytic potential of the influenza virus in glioma therapy
Glioblastoma remains a tumor with one of the most unfavorable prognoses in clinical oncology. Given the insufficient effectiveness of standard treatment modalities, oncolytic virotherapy is being actively developed. However, the influenza virus has so far remained on the periphery of scientific…
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Artikel Jurnal
Unravelling vancomycin resistance in newly emerging Enterococcus species
BACKGROUND: Enterococci, commonly found in the gastrointestinal, biliary, and genitourinary tracts, are increasingly implicated in a wide range of clinical infections worldwide. Although E. faecalis and E. faecium account for the majority of enterococcal infections, diseases caused by emerging…
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Artikel Jurnal
Заболевания, ассоциированные с Т-лимфотропным вирусом типа 1 человека (HTLV-1)
ВВЕДЕНИЕ: Т-лимфотропный вирус типа 1 человека (HTLV-1) относится к семейству Retroviridae (род Deltaretrovirus ) и напрямую участвует в канцерогенезе. Геном HTLV-1 представлен плюс-цепью РНК, которая транскрибируется в провирусную ДНК, а затем встраивается в геном клетки хозяина. После интеграции…
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Construction of oncolytic reporter influenza viral vectors and assessment of their safety following intracranial administration in rats
INTRODUCTION: Oncolytic viruses are a promising approach for treating malignant brain tumors as part a of combination therapy. OBJECTIVE: To develop reporter influenza A viruses expressing NanoLuc luciferase and evaluate their safety following intracranial administration in rats. METHODS…