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ISSN 2512-9465 · Georg Thieme Verlag KG · 470 artikel di indeks
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Artikel Jurnal
Microcytic or Iron Deficiency Anemia as a Risk Factor for Cerebral Sinus Venous Thrombosis—Systematic Review and Exploratory Meta-analysis
Background Cerebral sinus venous thrombosis (CSVT) is a rare but severe neurological condition. Iron deficiency anemia (IDA) has been suggested as a risk factor. Recent experimental data in iron-deficient rodents show a potential pathophysiological link between IDA and increased thrombus formation…
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Artikel Jurnal
Clinical Event Rates and Patient Satisfaction with Generic Rivaroxaban in Atrial Fibrillation: The Prospective Guardian Study
Background The use of oral anticoagulants (OACs), especially direct oral anticoagulants (DOACs), for thromboprophylaxis in atrial fibrillation (AF) has increased over the last decade, and an increasing number of generic DOAC medications (particularly regarding rivaroxaban and apixaban) have been…
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Artikel Jurnal
Prognostic Re-evaluation of Antinuclear Antibodies in Childhood Immune Thrombocytopenia
Background In the autoimmune bleeding disorder childhood immune thrombocytopenia (ITP), antinuclear antibodies (ANA) have been suggested as potential biomarkers for predicting chronic ITP. Unfortunately, published evidence remains conflicting and testing is not currently recommended in clinical…
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Artikel Jurnal
Antiphospholipid Syndrome in Chronic Thromboembolic Pulmonary Hypertension and Chronic Thromboembolic Pulmonary Disease without Pulmonary Hypertension: Prevalence and Clinical Impact in a Dutch Cohort
Antiphospholipid syndrome (APS) is a prothrombotic autoimmune disorder associated with venous thromboembolism (VTE) and chronic thromboembolic pulmonary hypertension (CTEPH). Current guidelines recommend APS screening in CTEPH patients. The exact prevalence of APS in both CTEPH and chronic…
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Artikel Jurnal
Endotheliopathy in CAR T-Cell Therapy: Mechanistic Insights into the VWF/ADAMTS13 Axis and the Angiopoietin–Tie2 Pathway
Chimeric antigen receptor (CAR) T cell therapy has transformed the management of hematologic malignancies, yet its clinical success is tempered by severe immune-mediated toxicities, including cytokine-release syndrome (CRS) and immune effector cell–associated neurotoxicity syndrome (ICANS), often…
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Artikel Jurnal
Ultra-Low Dose Argatroban in Heparin-Induced Thrombocytopenia with Thrombocytopenia and Hypofibrinogenemia: A Case Report
Heparin-induced thrombocytopenia (HIT) with thrombosis typically necessitates immediate therapeutic-dose anticoagulation, yet management becomes exceedingly complex when a profound bleeding risk coexists. We report a unique case of serologically confirmed HIT developing during low-molecular-weight…
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Artikel Jurnal
Tissue Factor/Factor XIa Dual-activated Thrombin Generation is Able to Reliably Measure Thrombin Generation at All Hemophilia A Disease Severities
Introduction Predicting bleeding in hemophilia A is difficult due to limitations of existing factor VIII (FVIII) activity assays, which correlate poorly with clinical bleeding tendency. Measurement of thrombin generation (TG) by calibrated automated thrombography (CT) may be an alternative to…
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Artikel Jurnal
Beyond Rebalanced Haemostasis: Haemostatic Phenotypes, Thrombin Generation, and Clinical Risk in Chronic Liver Disease
Advanced chronic liver disease (ACLD) profoundly remodels haemostasis through concurrent reductions in procoagulant factors and natural anticoagulants, qualitative platelet abnormalities, elevated von Willebrand factor and factor VIII, and dynamic alterations in fibrinolysis. Although rebalanced…
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Artikel Jurnal
A Novel Complete F8 Tandem Duplication Causing Elevated Factor VIII Activity and Associated with Venous Thromboembolism
Background Coagulation factor VIII (FVIII) is a critical component of the intrinsic coagulation pathway. While elevated FVIII levels are an established risk factor for venous thromboembolism (VTE), genetic variants in the F8 gene directly causing such elevations remain scarce. Here, we report a…
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Artikel Jurnal
Diabetes, Protein Misfolding, and Heat Stress: Molecular Insights and Translational Perspectives
Diabetes mellitus (DM), particularly type 1 (T1D) and type 2 (T2D), is a growing global health burden with complex pathophysiology extending beyond glucose dysregulation. Both forms of diabetes involve cellular stress, chronic inflammation, and β-cell dysfunction. Heat shock proteins (HSPs), key…