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Clinical and Translational Neuroscience
Scopus
ISSN 2514-183X · MDPI AG · 226 artikel di indeks
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Repeated Exposure to Electroconvulsive Seizures Induces Autistic-like Pathology in Mice
Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by impaired social interactions, communication deficits, and excessive repetitive behaviors. While ASD has a strong genetic basis, growing evidence suggests that epileptic seizures may serve as environmental risk factors…
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Uhthoff’s Phenomenon—A Scare or Real Threat to Multiple Sclerosis Patients? A Narrative Review
Uhthoff’s phenomenon (UP) is a transient, fully reversible exacerbation of pre-existing neurological deficits in multiple sclerosis (MS) patients, triggered by minor elevations in core body temperature. In clinical practice, UP is a frequent source of distress, often misidentified as an acute…
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Translating Neuroscience into Architectural Research: A Critical Narrative Review and Translational Framework of the Academy of Neuroscience for Architecture (ANFA)
Recent developments in cognitive neuroscience, neuroimaging, and embodied cognition have stimulated growing interest in neuroscience-informed architecture. However, despite the rapid expansion of the field, neuroarchitectural scholarship remains conceptually fragmented and methodologically diverse…
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The ABCDE Preoperative Framework for Functional Neurosurgery: A Structured Workflow Model Associated with Fewer Late-Stage Surgical Cancellations in a Single-Center Before-and-After Study
Background: Same-day or post-admission cancellation of elective surgery is associated with inefficient operating room utilization, patient distress, and disruption of coordinated perioperative care. Functional neurosurgery is particularly vulnerable to late-stage cancellation because procedural…
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Volume-Based Stratification of Lumbar Foraminal Stenosis: A Single-Center Cohort Integrating MRI/CT Morphometrics with Stepwise Interventional, Minimally Invasive and Decompression–Stabilization Surgery
Background: Lumbar foraminal canal stenosis (LFS) is typically multifactorial: disk height loss and bulging, facet hypertrophy/osteophytes, ligamentous thickening, and post-inflammatory or post-interventional scarring. Methods: To develop and implement a structured system for surgical care in…
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Cladribine: A Therapy Bringing Hope for Relapsing Multiple Sclerosis
Background: Multiple sclerosis (MS) is a chronic autoimmune neurological disorder that affects the central nervous system. Its exact cause remains unknown, but it is believed to result from both genetic predisposition and environmental factors. The two MS phases include a progressive phase and a…
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Peripheral Oxytocin Following Early-Life Stress: A Translational Systematic Review and Meta-Analysis of Human and Rodent Studies
Early-life stress (ELS) is associated with persistent oxytocinergic alterations, yet peripheral oxytocin (OT) changes in ELS-exposed adults remain inconsistent. To our knowledge, this translational systematic review and meta-analysis is the first to jointly synthesize human and rodent evidence on…
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Clinical Efficacy, Cost-Effectiveness, and Caregiver Satisfaction in Clinical Practice Compared to Standard Care: 12-Month Longitudinal Analysis of the Application of Parkinson’s KinetiGraph
Background: Parkinson’s disease (PD) is a progressive neurodegenerative disorder marked by both motor and non-motor symptoms. The home-based wearable sensor monitoring Parkinson’s KinetiGraph (PKG) evaluates clinical efficacy, caregiver satisfaction, and cost-effectiveness in the clinical…
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Head CT in Adult Mild Traumatic Brain Injury: A Global Review of Indications and Decision Rules
Mild traumatic brain injury (mTBI) in adults is extremely common worldwide, but only a small fraction of these patients harbor clinically significant intracranial injuries. Computed tomography (CT) of the head is the standard diagnostic tool to detect traumatic brain hemorrhages or lesions, yet…
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EEG Analysis in Benign Epilepsy with Centro-Temporal Spikes: A Comprehensive Review
Electroencephalogram (EEG) methods for the diagnosis of Benign Epilepsy with Centrotemporal Spikes (BECTS) are reviewed. The focus is on procedures reported for EEG analysis and diagnosis in BECTS, since some recent and potential applications of artificial intelligence (AI) aim to enhance the…
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Neuroimaging Correlates of the NIH Toolbox Cognition and Trail Making Tests: Normative Benchmarks in Healthy Aging
The National Institutes of Health (NIH) Toolbox cognition battery and Trail Making Tests (TMT) are widely used to quantify cognitive aging and to detect early cognitive vulnerability in Alzheimer’s disease and related conditions. However, these tests are often treated as interchangeable markers of…
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Surgical and Non-Surgical Outcome of Asymptomatic Lumbosacral Lipomas in Children: A Systematic Review
Background: The management of asymptomatic lumbosacral lipomas remains controversial, with studies reporting both prophylactic surgery and conservative management. This review compares conservative and surgical treatment approaches for asymptomatic lumbosacral lipomas in children, analyzing…
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Abdominal and Transcranial Photobiomodulation as a Gut–Brain Axis Therapy in Down Syndrome Regression Disorder: A Translational Case Report
Down Syndrome Regression Disorder (DSRD) is a rare but severe neuropsychiatric condition characterized by abrupt loss of speech, autonomy, and cognitive abilities in individuals with Down syndrome, often associated with immune dysregulation and gut–brain axis dysfunction. We report the case of an…
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Cross-Validation of Neurodegeneration Biomarkers in Blood and CSF for Dementia Classification
Objective: Alzheimer’s disease (AD) and other forms of dementia are a heterogeneous group of neurodegenerative diseases characterized by progressive cognitive decline. Differential diagnosis between AD and other dementias is crucial for choosing the optimal treatment strategy. Currently…
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Physiological Signals and Demographic-Driven Prediction for Older Adults’ Cognitive Functions Under Complex Indoor Thermal and Lighting Environments
Background: Recent studies have highlighted the significant impact of combined thermal and lighting conditions on human comfort. However, there is limited understanding of how these factors influence cognitive performance in older adults. This study explored the effects of complex thermal and…
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Successful In Situ Management of Intrathecal Baclofen Pump-Associated Staphylococcus Epidermidis Meningitis: A Case Report
Objective: Our objective was to report the successful in situ management of Staphylococcus epidermidis meningitis following intrathecal baclofen pump implantation without removing the device. Design: This was a single case report with clinical follow-up. Subjects/Patients: We discuss a 34-year-old…
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Cross-Regional Comparison of CDCA8 Gene Expression and Prognosis in Glioma Patients: A Meta-Analysis Based on CGGA and TCGA Databases
Objective: CDCA8 is frequently overexpressed in malignant tumors and linked to poor prognosis. This study evaluated the prognostic significance of CDCA8 expression in glioma patients using the CGGA and TCGA datasets. Methods: Clinical and expression data of glioma patients from CGGA and TCGA were…
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In Memoriam—Prof. Dr. Med. Christian W. Hess (1946–2024)
With the death of Prof [...]
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Biomarkers for Post-Traumatic Epilepsy: Advances in Imaging, Molecular Signatures, and AI-Assisted Prediction
Early diagnosis of post-traumatic epilepsy (PTE) is crucial for timely intervention. However, it is hampered by the lack of reliable biomarkers. In this review, we provide a comprehensive summary of current advances in PTE biomarker research, drawing primarily on evidence from human cohort studies…
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Developing Evidence-Based Program Recommendations for Children and Youth Impacted by ADHD: A Systematic Review of the Literature
Background: Attention-Deficit Hyperactivity Disorder (ADHD) is a complex neurodevelopmental disorder affecting executive functions such as impulse control, focus, and organization. This study addresses three research questions: current models and gaps in ADHD interventions, ways to enhance…