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South African Journal of Oncology
ISSN 2518-8704 · AOSIS · 173 artikel di indeks
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Artikel Jurnal
Ambulatory use of blinatumomab in paediatric patients with relapsed or refractory B-cell acute lymphoblastic leukaemia at a single centre in South Africa
Acute lymphoblastic leukaemia (ALL) is the most common childhood cancer, with B-ALL comprising approximately 85% of all cases. Despite a high cure rate, those with refractory disease and/or relapsed (R/R) B-ALL have an inferior overall survival. Blinatumomab, a novel therapy, is a bispecific…
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Artikel Jurnal
Table of Contents Vol 9 (2025)
This Table of Contents reflects the print compilation of peer-reviewed articles published in the journal. Each article listed was originally published online under the journal’s open access model and remains individually accessible and citable. This compilation has been created solely for print…
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Artikel Jurnal
Chemotherapy-induced seizures: A rare case of paclitaxel-induced neurotoxicity at Chris Hani Baragwanath Oncology Centre
Paclitaxel is widely used for advanced Kaposi sarcoma (KS) in resource-limited settings because of cost-effectiveness and proven efficacy. Neurotoxicity is recognised, but infusion-related seizures are exceedingly rare, particularly in human immunodeficiency virus (HIV)-positive patients. A…
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Artikel Jurnal
A retrospective study on the incidence and outcomes of hepatoblastoma in relation to prognostic indicators at Universitas Academic Hospital, Bloemfontein, South Africa (2000–2022)
Background: Hepatoblastoma (HB) is the most common solid liver cancer in childhood. Globally, survival has significantly improved with advanced treatment modalities. However, survival is poor in low-middle-income countries (LMICs) due to advanced-stage presentation. Aim: The aim was to evaluate the…
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Artikel Jurnal
Age and full blood count parameters predict survival in acute myeloid leukaemia at a Cape Town tertiary academic centre
Background: Acute myeloid leukaemia (AML) is a common and aggressive haematological neoplasm. Limited studies of AML in South Africa have shown differences in age at diagnosis and overall survival (OS) compared to international studies. Aim: To determine the demographics, subtype and OS of AML…
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Artikel Jurnal
Assessing shift in breast cancer stage from the anatomical staging classification to the clinical prognostic staging system
Background: Breast cancer is the most frequently diagnosed malignancy among women and a significant health burden in South Africa. The American Joint Committee on Cancer (AJCC) 8th Edition incorporates biological markers (oestrogen receptor, progesterone receptor, human epidermal growth factor…
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Comparison of electronic portal imaging device-based Winston–Lutz analysis software
Background: Stereotactic radiosurgery (SRS) with a linear accelerator requires submillimetre geometric accuracy. The Winston–Lutz (WL) test verifies coincidence among radiation, mechanical, and imaging isocentres. While portal imaging (EPID)-based WL methods offer rapid assessments, results may…
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Artikel Jurnal
Comparison of magnetic resonance imaging and B-mode ultrasound findings in children with retinoblastoma
Background: Retinoblastoma is the most frequently occurring primary intraocular neoplasm in the paediatric population and has a good prognosis when treated early. Magnetic resonance imaging (MRI) and B-mode ultrasound are both highly sensitive for identifying features of retinoblastoma. Aim: To…
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Artikel Jurnal
A South African perspective on MYD88 and CXCR4 variants in lymphoplasmacytic lymphoma or Waldenström macroglobulinaemia
Background: Lymphoplasmacytic lymphoma (LPL) is a small mature B-cell neoplasm that primarily involves the bone marrow. When associated with an IgM paraprotein, it is referred to as Waldenström macroglobulinaemia (WM). Variants in the MYD88 and CXCR4 genes are among the most common genetic…
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Prevalence and outcome of human papilloma virus-mediated oropharyngeal squamous cell carcinoma in a low- and middle-income setting
Background: Oropharyngeal squamous cell carcinoma (OPSCC) is divided into two distinct disease entities, distinguished by p16 status, which confers significant prognostic benefit when positive (human papilloma virus-mediated). Limited data exist in low- and middle-income countries (LMICs) to…
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Artikel Jurnal
An assessment of traditional and complementary medicine utilisation in cancer patients from KwaZulu-Natal, South Africa: A cross-sectional study
Background: Traditional and complementary medicine (TCM) use among cancer patients is increasing globally; however, it remains under-researched. Anticancer drugs have a narrow therapeutic window, and the use of complementary products may interact with chemotherapy. Aim: This study aims to…
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Artikel Jurnal
Outcomes of an acute lymphoblastic leukaemia cohort between 2008 and 2017 at a South African paediatric oncology unit
Background: Acute lymphoblastic leukaemia (ALL) is the most common childhood cancer, yet few studies have reported the treatment outcomes, toxicity patterns and relapse rates in low- and middle-income countries. Aim: To investigate overall survival (OS) and toxicity patterns in children with ALL…
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Artikel Jurnal
An interim analysis of the national treatment guideline for paediatric germ cell tumours and sex cord stromal tumours by the South African Association of Paediatric Haematology Oncology
Background: The South African Association of Paediatric Haematology Oncology (SAAPHO) developed a national treatment guideline for children with benign and malignant extracranial germ cell tumours (MEGCTs) and sex cord stromal tumours (SCSTs), named MEGCT-2016, and prospectively enrolled them into…
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Artikel Jurnal
Extrarenal Wilms tumour: A rare cause for retroperitoneal mass in children
Nephroblastoma (Wilms tumour) is one of the most common paediatric solid tumours, with a prevalence of 5% globally and 13.5% in South Africa. However, extrarenal Wilms tumour (ERWT) is a rare disease, and fewer than 100 cases have been reported in the paediatric age group. Contribution: In this…
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Artikel Jurnal
‘Involvement of the rehabilitation interprofessional teams is crucial in cancer care’, health professionals’ perspective, South Africa
Background: Patients diagnosed with cancer who are undergoing treatment may experience symptoms such as pain, fatigue and anxiety. Moreover, the diagnosis, progression and treatment of cancer can severely hinder physical activity levels and overall well-being. Evidence on integrating rehabilitation…
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One-week adjuvant breast radiotherapy: Retrospective outcomes from a Johannesburg oncology unit
Background: A 1-week, ultra-hypofractionated adjuvant radiation regimen has been found to be non-inferior to the standard 3-week regimen in women with early breast cancer. Aim: The study aimed to compare the patient and treatment characteristics of women receiving a 1-week (26 Gy in 5 fractions)…
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Artikel Jurnal
Osteosarcoma in children and adolescents: Experience from a tertiary hospital in South Africa
Background: Osteosarcoma (OS) is the most common malignant primary bone tumour in childhood and adolescence. There is a paucity of data regarding the characteristics, management and outcomes in low- and middle-income countries, including South Africa. Aim: This article describes the clinical…
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The diffuse large B-cell lymphoma disease profile at Charlotte Maxeke Johannesburg Academic Hospital from July 2020 to June 2022
Background: Diffuse large B-cell lymphoma (DLBCL) is one of the most common non- Hodgkin lymphomas (NHL) in adults, and there is limited clinical data available for patients treated in low-resource settings with a high human immunodeficiency virus (HIV) infection burden. Aim: This article describes…
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Artikel Jurnal
Role of computed tomography in detecting incidental venous thromboembolism in cancer patients
Background: Cancer is one of the major risk factors for venous thromboembolism (VTE). The prevalence of incidental VTE among cancer patients in South Africa is unknown. Aim: To determine the presence and location of VTE, find out if VTE is more common in certain cancer types, and to determine the…
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Artikel Jurnal
Culture-positive mould infections in patients with haemato-oncological diseases
Background: Moulds are increasingly recognised as important pathogens carrying a high morbidity and mortality in critically ill and immune-compromised patients, including those with haematological neoplasms (HNs) and aplastic anaemia (AA). Our understanding of these diseases remains incomplete…