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Al-Azhar Journal of Pharmaceutical Sciences, Pp 143-157 (2026)
ISSN 2535-1958 · Al-Azhar University, Faculty of Pharmacy · 352 artikel di indeks
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DISCOVERY OF A NOVEL PHENYLAMINE-PURINE CHEMOTYPE AS A POTENTIAL EGFR INHIBITOR USING AN INTEGRATED AI-DRIVEN DRUG DESIGN PIPELINE
The discovery of novel Epidermal Growth Factor Receptor (EGFR) inhibitors remains critical for overcoming resistance in targeted oncology. We report a fully integrated, artificial intelligence-driven drug discovery pipeline combining generative modeling, structure-based virtual screening…
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EVALUATION OF IN -VITRO ANTIOXIDANT ACTIVITIES OF EUCALYPTUS CAMALDULENSI DEHNH
This study evaluated the In vitro antioxidant properties of the ethanol leaf extract of Eucalyptus camaldulensi Dehnh using four standard assays to determine its free radical scavenging capacity and ferric reducing potential. Antioxidant activity was assessed using DPPH free radical scavenging…
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SYNTHESIS, REACTIVITY, AND MEDICINAL PERSPECTIVES OF THIAZOLIDINE DERIVATIVES: A NARRATIVE REVIEW
Thiazolidine derivatives represent an important class of sulfur- and nitrogen-containing heterocyclic compounds that have attracted significant interest in medicinal chemistry due to their diverse biological activities and versatile synthetic accessibility. The thiazolidine scaffold, particularly…
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SPECTROPHOTOMETRIC QUANTITATIVE ANALYSIS OF REMDESIVIR IN THE PRESENCE OF ITS ALKALINE-INDUCED DEGRADATION PRODUCT
Remdesivir is a recent antiviral, previously used for the treatment of Ebola virus infections, which was approved by the US-FDA in 2020 for the treatment of infections caused by the SARS-CoV-2 virus. The main purpose of this work is to establish three simple, sensitive, accurate, and precise…
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QUINOXALINE DERIVATIVES AS A PROMISING SCAFFOLD FOR CANCER TREATMENT: GLOBALLY APPROVED DRUGS AND REPORTED COMPOUNDS
Quinoxaline derivatives constitute a privileged class of heterocyclic scaffolds that have gained increasing attention in anticancer drug discovery. Owing to their favorable structural features and target versatility, quinoxaline-based compounds have emerged as promising lead molecules against a…
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DIPHENYL ETHERS TARGETING TUBERCULOSIS: SYNTHESIS, SCREENING, AND SAFETY EVALUATION
New diphenylether derivatives 3-14 were designed and synthesized through simple chemical pathways. The structure of the new compounds was confirmed via IR, 1H-NMR 13C-NMR and elemental analysis. The new compounds were subjected to in vitro anti-tuberculosis activity against various strains of…
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PHYTOCHEMICAL AND BIOLOGICAL STUDY OF HELICHRYSUM SANGUINEUM L. ASTERACEAE (COMPOSITAE) MARKETED IN THE EGYPTIAN HERBAL MARKET.
أدى التحليل الكيميائي النباتي للأجزاء الهوائية لنبات الهيليكريسوم سانغوينوم (Helichrysum sanguineum L.)، التي تم الحصول عليها من سوق الأعشاب المصرية، إلى عزل خمسة مركبات معروفة، هي: الروتين ( 1 )، وحمض 1،3-ثنائي كافيلوكينيك ( 2 )، وكيرسيتين 3- O- (6``- O - trans- كافويل)-β-D-غلوكوبيرانوزيد ( 3 )،…
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QUINOXALINE DERIVATIVES AS PROMISING ANTICANCER AGENTS: A COMPREHENSIVE REVIEW OF MECHANISMS AND RECENT ADVANCEMENTS
Cancer remains a leading cause of global morbidity and mortality, underscoring the urgent need for more effective and less toxic therapeutic agents. This review highlights the significant potential of quinoxaline, a nitrogen-containing heterocyclic scaffold, in the development of anticancer drugs…
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UNRAVELING THE CYTOKINE STORM: IL-6 AND INF-Γ AS KEY INDICATORS OF SEVERITY IN COVID-19 PATIENTS
The clinical spectrum of COVID-19 is characterized by significant variability in disease severity and outcomes, which are often influenced by fluctuations in inflammatory mediators during the cytokine storm. This study aims to identify routine blood parameters as potential indicators of disease…
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NATUREGLOW® AS A DIGITAL TOOL FOR NATURAL SKINCARE APPLICATIONS; A COMPREHENSIVE REVIEW
The introduction of mobile applications (apps) has transformed patient care, diagnostics, and medical education, among other fields of healthcare. This paper aims to highlight the various uses of mobile applications in healthcare, including managing chronic illnesses, facilitating remote…
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“SIMULTANEOUS DETERMINATION OF CO-ADMINISTERED METFORMIN AND AMIODARONE IN PHARMACEUTICAL PREPARATIONS AND SPIKED HUMAN PLASMA USING RP-HPLC METHOD”
The goal of this work is to establish a sensitive, accurate, precise, and selective RP-HPLC method for the simultaneous determination of metformin and amiodarone in bulk powder, pharmaceutical preparations, and plasma. Chromatographic separation was performed using a Kinetex C18 column (100 × 4.6…
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DETERMINATION OF LACIDIPINE IN PRESENCE OF ITS ACID-INDUCED DEGRADATION PRODUCT IN BULK AND PHARMACEUTICAL DOSAGE FORM BY FIRST DERIVATIVE, DUAL WAVELENGTH AND SIMULTANEOUS EQUATION UV SPECTROPHOTOMETRIC METHODS
Three simple, precise and economical UV spectrophotometric methods have been developed for the estimation of lacidipine and its degradation product in bulk and pharmaceutical formulations. The first method was first derivative and the linear correlation was obtained between the amplitudes at 249.40…
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SPECTROFLUORIMETRIC DETERMINATION AND OPTIMIZATION OF FLURALANER IN PHARMACEUTICAL FORMULATIONS
A sensitive and accurate native spectrofluorimetric method was developed and validated for the quantification of Fluralaner in pharmaceutical formulations. Fluralaner exhibited native fluorescence with emission detected at 333 nm following excitation at 265 nm. Method optimization involved…
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DESIGN, SYNTHESIS AND ANTIMICROBIAL EVALUATION OF SOME NEW HETEROCYCLIC COMPOUNDS
The escalating threat of antimicrobial resistance (AMR) necessitates innovative antibiotics to combat multidrug-resistant pathogens. This study explores the design, synthesis, and antimicrobial evaluation of novel heterocyclic compounds derived from the methylthiazole scaffold, recognized for its…
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SIMULTANEOUS CHEMOMETRIC AND SPECTROPHOTOMETRIC DETERMINATION OF CO-ADMINISTERED LEVAMISOLE AND TRICLABENDAZOLE IN PHARMACEUTICAL DOSAGE FORM USED IN TREATMENT FASCIOLA-INFECTED SHEEP
The goal of this work is to evaluate chemometric and spectrophotometric approaches. Among these techniques will be dual wavelength, simultaneous equation, and ratio derivative method, as well as classical least-squares (CLS), artificial neural networks (ANN) and genetic algorithm artificial neural…
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DESIGN AND SYNTHESIS OF SOME NEW ARYLAZOLE BASED DERIVATIVES FOR PHARMACOLOGICAL TESTING
The urgent need for innovative therapeutic solutions is highlighted by the recent rise in antimicrobial resistance. This study describes the design, synthesis, and biological evaluation of a novel series of phenyl thiazolidinone derivatives aimed at combating MRSA. The chemical structures of these…
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RECENT ADVANCES ON NEW QUINAZOLINE DERIVATIVES AS DNA INTERCALATORS AND TOPOISOMERASE II INHIBITORS
يُعدّ السرطان عبئًا صحيًا عالميًا كبيرًا، ينشأ عن النمو غير المنضبط للخلايا غير الطبيعية التي تُعيق وظائف الجسم الطبيعية. ويركّز جزء كبير من علاج السرطان على المركبات التي تستهدف الحمض النووي أو الإنزيمات المرتبطة به، مما يُعطّل العمليات الخلوية الأساسية ويُحفّز موت الخلايا السرطانية. ولا تزال هذه…
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PHYTOCHEMICAL AND BIOLOGICAL INSIGHTS INTO THE GENUS ATRIPLEX: A HALOPHYTIC TREASURE IN ETHNOMEDICINE
Halophytes have garnered increasing attention due to their remarkable adaptation to saline and arid environments, as well as their capacity to produce a wide range of bioactive metabolites. Among them, the genus Atriplex (saltbush), comprising 300-400 species of angiosperms, is widely distributed…
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UNRAVELLING THE BIO-SIGNIFICANCE OF SELECTED FIVE-MEMBERED HETEROCYCLES AS POTENTIAL IMMUNOMODULATORY ANTICANCER COMPOUNDS
لا يزال السرطان يُمثل تحديًا صحيًا عالميًا مُلحًا ومتعدد الأوجه، ويُساهم بشكل كبير في معدل الوفيات السنوي. على الرغم من حصول العديد من الأدوية المضادة للأورام على الموافقات التنظيمية، وإجراء العديد من التجارب السريرية لتحديد العلاجات الفعالة، إلا أن العديد من العلاجات الحالية تُعاني من عيوب كبيرة،…
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ROOTS AND RHIZOMES WITH ACTIVITY AGAINST ULCERATIVE COLITIS AND MECHANISM: A REVIEW OF IN VIVO ANIMAL STUDIES
التهاب القولون التقرحي (UC) هو حالة متكررة يمكن وصفها بأنها التهاب مزمن في القولون. يُعد الساليسيلات الخيار العلاجي الأول لحالات التهاب القولون التقرحي الخفيفة أو المتوسطة، بينما قد تتطلب الحالات الشديدة الكورتيكوستيرويدات أو مثبطات المناعة. إلا أن هذه العلاجات التقليدية تعاني من محدودية توافرها…