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Records of Pharmaceutical & Biomedical Sciences
ISSN 2535-2091 · Suez Canal University, Faculty of Pharmacy · 331 artikel di indeks
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Carvacrol: A Natural Compound with Promising Effects
Natural products remain a rich source of structurally diverse bioactive compounds that continue to play a central role in modern drug discovery. Despite extensive pharmacological studies on many medicinal plants, numerous plant-derived constituents are still insufficiently explored. Carvacrol, a…
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Phytochemical and Biological Short Review Of Subfamily Aurantioideae.
The subfamily Aurantioideae, belonging to the family Botany Rutaceae, represents one of the most economically and medicinally significant groups of flowering plants distributed throughout tropical and subtropical regions. This subfamily comprises several important genera including Citrus, Murraya…
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Green Analytical Chemistry: Principles, Challenges, Strategies and Assessment Tools
Green analytical chemistry (GAC) focuses on decreasing the adverse effects of analytical activities on human safety, human health, and environment by reducing the use of hazardous chemicals and waste generation in analytical procedures without compromising method performance. Most of the suggested…
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Expanding the Therapeutic Landscape of Rheumatoid Arthritis: Natural Products and Drug Repurposing as Emerging Therapeutic Strategies
Rheumatoid arthritis (RA) is a chronic systemic autoimmune disorder characterized by persistent synovial inflammation, progressive cartilage destruction, and irreversible joint damage, resulting in substantial disability and reduced quality of life. Despite major therapeutic advances achieved…
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AI and ML assistance for the synthesis, characterization, and applications of carbon dots : A comprehensive review
Carbon dots (CDs), defined as carbon quantum dots (CQDs), represent an emerging class of zero-dimensional carbon-based nanomaterials branded by quasi-spherical morphology and nanoscale dimensions, ranging from 1 to 10 nm. By the 2010s, CDs have advanced from simple discoveries to complex designed…
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Anandamide Attenuates Mercuric Chloride– Induced Hepatotoxicity Through Modulation of HMGB1/RAGE/NF-κB Inflammatory Signaling
Purpose: This study sought to examine the possible effect of anandamide (AEA) on hepatotoxicity triggered by mercuric chloride (HgCl2) through amelioration of hepatic inflammation in adult male rats.Methods: Twenty- one male Sprague Dawley rats were randomized into three groups. Control group rats…
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Modulation of Wnt/β-Catenin Signaling and Cartilage Catabolic Mediators in Monosodium Iodoacetate-Induced Osteoarthritis in Rats
Background and Aim: Osteoarthritis (OA) is characterized by progressive cartilage degeneration and chronic inflammation, with dysregulation of the Wnt/β-catenin pathway contributing to disease progression. This study evaluated the effects of trimetazidine (TMZ) and sitagliptin (STG) on inflammatory…
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A Minireview on the Phytochemical Constituents and Pharmacological Activities of the Genus Heterotheca (Asteraceae)
The genus Heterotheca (Cass.), belonging to the family Asteraceae, is widelydistributed across the arid and sandy habitats of North America and Mexico andhas become invasive in numerous subtropical and Mediterranean regions,including the Sinai Peninsula, Egypt. Several species of Heterotheca…
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Anticancer Activities of Ferulic and p-Coumaric Acid Derivatives: Mini Review
Cancer is one of the most intricate diseases humanities faces today, with over 200 different types that require specialized treatment approaches. Meanwhile, there is considerable interest in exploring the potential role of herbal and complementary medicines in the management of various cancers. In…
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Molecular Mechanisms involved in the Pathogenesis of DN
Diabetic nephropathy (DN) is one of the most serious microvascular complications of diabetes mellitus and a leading cause of end-stage renal disease (ESRD) worldwide. Its pathogenesis involves complex and interrelated molecular mechanisms triggered primarily by chronic hyperglycemia. Persistent…
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Nephroprotective Strategies Against Methotrexate-Induced Renal Toxicity: Insights from Animal Models.
Methotrexate (MTX) is a cornerstone chemotherapeutic and immunosuppressive agent widely used in oncology and autoimmune disorders. Despite its clinical efficacy, MTX is frequently associated with nephrotoxicity, ranging from asymptomatic renal impairment to severe acute kidney injury, which can…
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The Emerging Role of Long Non-Coding RNAs in the Pathogenesis and Management of Rheumatoid Arthritis
Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease that primarily affects synovial joints and is frequently associated with a wide spectrum of extra-articular manifestations, including cardiovascular, pulmonary, and ocular complications. The disease is characterized by…
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Leflunomide: Pharmacological Profile and Emerging Evidence of Nephrotoxicity
Leflunomide, a disease-modifying anti-rheumatic drug (DMARD), exerts potent immunosuppressive effects by selectively inhibiting dihydroorotate dehydrogenase, thereby impairing de novo pyrimidine synthesis and suppressing lymphocyte proliferation. Although widely used in autoimmune diseases such as…
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Mucoadhesive Systems Overcome Gastrointestinal Barriers to Enable Delivery of Plecanatide and Curcumin: A Systematic Review.
The oral route remains the most preferred for drug administration due to its non-invasiveness and patient compliance. However, dynamic physiological barriers, including variable pH, enzymatic degradation, rapid transit time, and the protective mucus layer, significantly hinder effective delivery of…
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Recent Advances in Elastic Nanocarriers for Dermal and Transdermal Drug Delivery
Elastic nanocarriers, including transfersomes, ethosomes, and spanlastics, represent a new generation of vesicular drug delivery systems designed to overcome the limitations of conventional carriers in dermal and transdermal applications. Their ultra-deformable and flexible bilayer structures…
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Application of CHROMagar Candida in the identification of clinically relevant Candida Species
AbstractBackground: Candida species rank as the second most common cause of vulvovaginitis. The incidence of Candida non-albicans species has increased recently, necessitating their identification due to their increased resistance to antifungal agents. This study aimed to assess the effectiveness…
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Genetic Insights into Type 1 Diabetes Mellitus Pathogenesis; Spotlighting CIITA and CLEC2D as Polymorphism Examples
Type 1 diabetes mellitus (T1DM) is a chronic autoimmune disorder characterized by immune-mediated destruction ofpancreatic β-cells, resulting in absolute insulin deficiency and lifelong dependence on exogenous insulin therapy. Theetiology of T1DM is multifactorial, involving a complex interplay…
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Overview of the QuEChERS Method for Sample's extraction in different food, environmental and biological samples.
The QuEChERS method is a sample preparation technique that was first applied in analytical chemistry to extract and purify pesticide residues in food. QuEChERS is an acronym for (quick, easy, cheap, effective, rugged, and safe). The method has expanded in recent years to accommodate matrices other…
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Benzofuran Derivatives: Synthesis and Potential Therapeutic Role as VEGFR-2 Inhibitor
Benzofuran is a crucial heterocyclic scaffold in medicinal chemistry, known for its occurrence in a wide array of naturally occurring and synthetically derived bioactive compounds. Its fused aromatic and oxygen-containing ring system imparts favorable physicochemical properties allowing effective…
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Overview on Biological Activities of Thiazole Derivatives
Thiazole and its derivatives have garnered widespread attention in medicinal chemistry due to their remarkable range of biological activities. This heterocyclic scaffold is characterized by a five-membered aromatic ring that incorporates both nitrogen and sulfur atoms, a unique arrangement that…