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Advances in Biomarker Sciences and Technology
Scopus
ISSN 2543-1064 · KeAi Communications Co. Ltd. · 87 artikel di indeks
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Artikel Jurnal
Emerging biomarkers for human parasitic infections: Advances and future perspectives
Parasitic infections remain a major global public health challenge, disproportionately affecting populations in low- and middle-income countries and contributing to significant morbidity, mortality, and socioeconomic burden. Accurate and timely diagnosis is essential for effective disease control…
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Artikel Jurnal
Exploring trimethylamine N-oxide (TMAO) as a metabolic link between obstructive sleep apnea and cardiovascular risk: A cardiometabolic perspective
Obstructive Sleep Apnea (OSA) is a condition that obstructs the upper airway during sleep, inducing intermittent hypoxia that affects the host metabolism, and is associated with gut microbiome dysbiosis. The bidirectional link between host immunometabolism and the cardiovascular system connects…
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Artikel Jurnal
Role of Akkermansia muciniphila in improving gut health for the prevention of type 2 diabetes
Chronic inflammation, gut microbial dysbiosis, and metabolic dysregulation are closely interrelated and play a significant role in the pathogenesis of type 2 diabetes, a long-recognized global health problem. Akkermansia muciniphila has been identified as a predominant bacterial species that plays…
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Artikel Jurnal
FRF-HHO: Early ovarian cancer prediction using explainable fuzzy random forest optimized by Harris Hawks algorithm
Ovarian cancer remains one of the most lethal gynecological malignancies, largely due to delayed diagnosis and the absence of reliable early screening tools. This study proposes an interpretable machine learning framework that integrates Fuzzy Random Forest (FRF) with Harris Hawks Optimization…
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Artikel Jurnal
In silico screening of tripeptide inhibitors reveals potential lead compounds for targeting zika virus NS2B-NS3 protease
ZIKV is a public health threat causing neurological complications such as microcephaly and Guillain-Barre syndrome, with the additional risk of sexual transmission. The absence of FDA-approved drugs or vaccines for ZIKV, highlight the immediate requirement for potential therapeutics. A potential…
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Artikel Jurnal
Biomarker-guided precision immunotherapy in head and neck cancer: Harnessing toripalimab-tpzi as a PD-1 checkpoint inhibitor
The recent humanized anti-programmed death-1 (PD-1) monoclonal antibody, toripalimab-tpzi, has now become a promising immunotherapeutic agent in the control of head and neck cancer (HNC), especially head and neck squamous cell carcinoma (HNSCC), the most common form of the disease, constituting…
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Artikel Jurnal
Multicenter evaluation of M2BPGi as a biomarker for liver fibrosis and hepatocellular carcinoma in chronic hepatitis B and C patients in Malaysia
Background: Chronic hepatitis B (HBV) and C (HCV) cause major global morbidity, especially in settings with limited diagnostic access. Liver biopsy is not routinely used for fibrosis assessment because of its invasive nature, whereas elastography, a reliable non-invasive alternative, is often…
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Artikel Jurnal
Evaluation of solvent-dependent yield and toxicity of selected spices using brine shrimp and zebrafish bioassays: Implications for aquaculture applications
Spices are widely used culinary ingredients with notable antioxidant and antibacterial properties. In aquaculture, they function as immunostimulants and natural therapies, enhancing fish health and disease resilience. Nevertheless, certain spices may demonstrate toxicity and pose health risks as…
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Artikel Jurnal
Hybrid molecular-image fusion network for enhanced lung cancer diagnosis using CT images
Lung cancer is among the major causes of cancer-related deaths in the world, and the problem requires proper and timely diagnostic measures. The proposed study is HyMoIF-Net, a new radiogenomic deep learning framework that combines computer tomography (CT) imaging characteristics with gene…
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Artikel Jurnal
Proteomic and metabolomic alterations in response to systemic stress in vivo
Using liquid chromatography-tandem mass spectrometry, this study investigated the proteomic and metabolomic alterations associated with systemic stress in vivo. C57BL/6 mice were divided into two groups: control group and mice under stress, followed by proteomics and metabolomics analysis using…
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Artikel Jurnal
Methanol extract of Smritisagara Rasa attenuates neurobehavior, neurochemical and stress indicators in rotenone-induced Drosophila model of Parkinson's disease
Smritisagara Rasa (SSR), a traditional Ayurvedic herbo-mineral formulation, has long been prescribed for the treatment of Parkinson's disease (PD) since ancient times. Nevertheless, the underlying molecular mechanisms and treatment strategies remain unclear due to a lack of adequate experimental…
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Artikel Jurnal
The integration of artificial intelligence and biotechnology in medicine: accelerating novelty in biomarker-targeted discovery and drug delivery systems
Artificial intelligence (AI) and biotechnology are two transformative fields converging to benefit STEM because of their reliance on data and models. The tools from both fields have redefined and improved translational performance of laboratory investigations on drug and biomarker-targeted…
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Protective effects of nutritional and polyphenolic supplementation in polycystic ovarian syndromes
Hormonal abnormalities, insulin resistance, and chronic inflammation are the hallmarks of Polycystic Ovary Syndrome (PCOS), a prevalent endocrine condition affecting women of reproductive age. Oxidative stress is a key factor in the pathophysiology of PCOS, spurring interest in antioxidant-based…
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Artikel Jurnal
Mechanistic insights on effective ratio of Linoelaidic and Docosapentaenoic acid by modulating adipogenic and inflammatory biomarkers in 3T3-L1 preadipocytes
Obesity is a condition of energy balance in which nutrient intake consistently exceeds energy expenditure, increasing the risk of various potentially fatal disorders. Docosapentaenoic acid (DPA) is an omega-3 fatty acid that has been reported to provide a number of health benefits. However, the…
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Artikel Jurnal
In silico analysis of Coenzyme Q10 interaction with the heme-hemoglobin complex: Implications for oxidative stress and inflammation in severe malaria
Background: Plasmodium falciparum, the primary causative agent of severe malaria, catabolizes hemoglobin to obtain nutrients, resulting in the accumulation of toxic free heme. To mitigate this toxicity, the parasite converts heme into inert hemozoin. Chloroquine inhibits this detoxification…
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Artikel Jurnal
In vivo multi-omics evaluation of ellagic Acid–Gold nanoparticles from Syzygium cumini for glycemic improvement and β-cell preservation in type 2 diabetic mice
Diabetes mellitus remains a major global health challenge, affecting over 537 million adults worldwide and this number is expected to rise 783 million by 2045, underscoring the need for improved therapeutic strategies. In this study, we synthesized and evaluated ellagic-acid-loaded gold…
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Evaluation of withacoagulin from Withania coagulans for glycemic improvement and β-cell preservation in a type 2 diabetic model
Type 2 diabetes mellitus remains a global health emergency, with existing therapies often failing to achieve durable glycemic control or preserve pancreatic β-cell function. In this study, we isolated and purified withacoagulin, a novel withanolide from Withania coagulans, confirmed by NMR, MS…
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Artikel Jurnal
Bioscreening and phytochemical profiling of Phyllanthus niruri endophytic fungi with potential Anti-HCV applications
This study proposes a novel strategy for antiviral drug discovery by exploring endophytic fungi associated with Phyllanthus niruri, a medicinal plant traditionally recognized for its therapeutic value in liver disorders and viral infections. The research underscores the critical demand for…
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Artikel Jurnal
Molecular biomarkers and nano-immunopharmacology in inflammatory carcinoma: Bridging mechanisms and therapeutic translation
This section delineates the mechanistic framework linking chronic inflammation to carcinogenesis and critically explains how molecular biomarkers can be rationally exploited through nano-immunopharmacological strategies to enable precision therapy in inflammation-driven cancers. Chronic…