304 hasil

ENO1 inhibition synergizes with chidamide to induce ferroptosis in PTCL-NOS through metabolic remodeling

Feng Zhu; Mingxi Tian; Keyi Lu dkk.

Blood Science, Vol. 8 No. 1 · 2026 · Inggris · DOAJ Scopus

Enolase (ENO1) is a key enzyme involved in glycolysis and plays an important role in various types of cancer. This study explored the role and mechanism of ENO1 and the histone deacetylase inhibitor chidamide in peripheral T cell lymphoma, not otherwise specified (PTCL-NOS). Reverse transcription…

Driver mutation-defined molecular landscapes of essential thrombocythemia

Alejandra L. Lorenzen; Gang Huang

Blood Science, Vol. 8 No. 1 · 2026 · Inggris · DOAJ Scopus

A protocol for high-quality single-cell RNA sequencing with cell surface protein quantification

Sichong Han; Siqi Liu; Changya Chen

Blood Science, Vol. 8 No. 1 · 2026 · Inggris · DOAJ Scopus

Cellular indexing of transcriptomes and epitopes by sequencing (CITE-seq) enables the simultaneous analysis of transcriptomic and proteomic data at the single-cell level, providing a comprehensive view of cellular heterogeneity and function. In this study, we present a standardized approach for…

A pipeline for single-cell chromatin accessibility data analysis

Mengke Zhang; Changya Chen

Blood Science, Vol. 8 No. 1 · 2026 · Inggris · DOAJ Scopus

Single-cell chromatin accessibility analysis enables high-resolution dissection of regulatory elements and gene regulatory mechanisms. However, standardized and comprehensive analysis workflows remain limited. In this study, we present a streamlined pipeline for analyzing single-cell chromatin…

Systemic high-dose MTX and BTK inhibitors in vitreoretinal lymphoma: efficacy and survival analysis

Jing Gao; Li-wei Lv; Suo-wang Zhou dkk.

Blood Science, Vol. 8 No. 1 · 2026 · Inggris · DOAJ Scopus

The tumor microenvironment in hematologic malignancies: immune evasion, metabolic reprogramming, and therapeutic resistance

Menattullah Walid; Muhammad Saboor; Shafiul Haque dkk.

Blood Science, Vol. 8 No. 1 · 2026 · Inggris · DOAJ Scopus

Hematological malignancies, including leukemia, lymphoma, and multiple myeloma, develop within and remain dependent on a complex and dynamic tumor microenvironment (TME). Malignant cells interact continuously with the cellular and molecular components of the TME, which play a critical role in…

Functions of mitochondrial metabolism in hematopoiesis and hematopoietic malignancies

Siqin Yi; Huifang Zhang; Yue Sheng

Blood Science, Vol. 8 No. 1 · 2026 · Inggris · DOAJ Scopus

Mitochondria play crucial roles as metabolic hubs and signal-transduction platforms part in a series of vital cellular activities. Although the fundamental biological activities of mitochondria and their pivotal roles in solid tumors have received sufficient coverage, a thorough synthesis of their…

Novel gene variants in a rare case of SRY-negative 46, XX male syndrome with bone marrow failure by whole exome sequencing

Aoli Zhang; Lipeng Liu; Min Ruan dkk.

Blood Science, Vol. 8 No. 1 · 2026 · Inggris · DOAJ Scopus

G-CSF–induced hypercoagulability in two consecutive hematopoietic progenitor cell apheresis procedures: A case report

Yandy Marx Castillo-Aleman; Shinnette Lumame; Charisma Castelo dkk.

Blood Science, Vol. 8 No. 1 · 2026 · Inggris · DOAJ Scopus

Netupitant/palonosetron is effective for preventing chemotherapy-induced nausea and vomiting in high-dose melphalan conditioning before autologous stem cell transplantation: A real-world analysis

Le-Qing Cao; Jing Dai; Ting Wang dkk.

Blood Science, Vol. 8 No. 1 · 2026 · Inggris · DOAJ Scopus

High-dose melphalan (HDM) is the standard conditioning regimen before autologous stem cell transplantation (ASCT) in plasma cell malignancies. Despite prophylactic antiemetics, chemotherapy-induced nausea and vomiting (CINV) remains a prevalent challenge. We retrospectively compared the efficacy of…

Efficacy and safety of eltrombopag in the treatment of cancer therapy–induced thrombocytopenia: a large-scale, multicenter, retrospective study in China

Bingjie Ding; Yunfei Chen; Hongming Huang dkk.

Blood Science, Vol. 8 No. 3 · 2026 · Inggris · DOAJ Scopus

LPCAT3 is essential for leukemia progression and represents a therapeutic vulnerability in AML

Mutian Cao; Lizhen Cong; Yifei He dkk.

Blood Science, Vol. 8 No. 3 · 2026 · Inggris · DOAJ Scopus

Acute myeloid leukemia (AML) is a group of genetically and clinically heterogeneous malignancies characterized by clonal expansion of immature myeloid progenitors and profound disruption of normal hematopoiesis. Emerging evidence suggests that alterations in cellular homeostasis shape cancer…

Sequential glofitamab and consolidative ASCT plus CAR-T therapy achieved durable remission in relapsed/refractory DLBCL

Sijia Yan; Jiaying Wu; Mi Zhou dkk.

Blood Science, Vol. 8 No. 3 · 2026 · Inggris · DOAJ Scopus

Apoptosis-related gene model predicts the prognosis in patients with acute myeloid leukemia

Xiang Pei; Wenbing Liu; Yishuang Li dkk.

Blood Science, Vol. 8 No. 2 · 2026 · Inggris · DOAJ Scopus

Acute myeloid leukemia (AML) is a hematological malignancy with a high mortality rate and heterogeneous prognosis. Traditional risk stratification is based on the genetic classification in the 2022 guidelines of the European Leukemia Net. However, the risks of some patients remain unclear, and…

Allogeneic hematopoietic stem cell transplantation combined with dasatinib successfully treated adult acute lymphoblastic leukemia with e1a3 BCR-ABL1 fusion gene positivity: a case report and literature review

Wenhui Liu; Tao Wu; Yang Liu dkk.

Blood Science, Vol. 8 No. 2 · 2026 · Inggris · DOAJ Scopus

Breakthroughs and challenges of CAR-T cell therapy in treating hematologic malignancies of the central nervous system

Xiaoning Li; Haili Da; Jie Zhao dkk.

Blood Science, Vol. 8 No. 2 · 2026 · Inggris · DOAJ Scopus

Chimeric antigen receptor T (CAR-T) cell therapy has transformed hematologic cancer treatment; however, its application in patients with central nervous system (CNS) involvement remains challenging because of exclusion from key trials. Recent data show that CAR-T cells can breach the blood–brain…

A novel UBASH3B::PVT1 fusion in B-cell acute lymphoblastic leukemia with PAX5-PTD: a case report and literature review

Xinmei Zhuang; Yun Wang; Qian Yang dkk.

Blood Science, Vol. 8 No. 2 · 2026 · Inggris · DOAJ Scopus

Refining favorable-risk classification in pediatric RUNX1::RUNX1T1 acute myeloid leukemia

Xi Zhang

Blood Science, Vol. 8 No. 3 · 2026 · Inggris · DOAJ Scopus

Febrile neutropenia adversely affects chemomobilization outcomes in patients with multiple myeloma and increases risk for post-transplant infection in those with lymphoma: real-world multicenter data

Hu Qian; Xinwei Wang; Liping Yang dkk.

Blood Science, Vol. 8 No. 3 · 2026 · Inggris · DOAJ Scopus

The precise impact of febrile neutropenia (FN) during chemomobilization on the collection of CD34+ peripheral blood stem cells and post-transplant infection(s) in patients with multiple myeloma (MM) and lymphoma undergoing autologous stem cell transplantation (ASCT) remains insufficiently…

Application value and challenges associated with plasma cell-free DNA metagenomic sequencing technology in the diagnosis of infections in patients with hematological disorders

Chunhui Xu; Teng Liu; Xuyan Zhang dkk.

Blood Science, Vol. 8 No. 3 · 2026 · Inggris · DOAJ Scopus

In patients with hematological disorders, the high risk of complex infections caused by immune dysfunction and intensive therapies poses a major challenge to the use of conventional microbiological tests (CMTs). Plasma cell-free DNA (cfDNA) metagenomic next-generation sequencing (mNGS) has emerged…