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Reports
ISSN 2571-841X · MDPI AG · 913 artikel di indeks
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Chemotherapy-Free Polatuzumab Vedotin and Rituximab (Pola-R) for Frail, Older Patients with Relapsed DLBCL: A Case for Geriatric Assessment and Shared Decision-Making
Background and Clinical Significance: Older, frail patients with relapsed diffuse large B-cell lymphoma (DLBCL) face limited treatment options due to poor tolerance for standard cytotoxic chemotherapy. While novel chemotherapy-free regimens like polatuzumab vedotin plus rituximab (Pola-R) have…
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Malignant Priapism as the Sole Initial Manifestation of Metastatic Carcinoma with Suspected Pulmonary Origin: A Case Report and Review of the Literature
Background and Clinical Significance: Malignant priapism is a rare manifestation of advanced malignancy caused by malignant infiltration of the corpora cavernosa. We report a case of persistent and refractory priapism associated with penile carcinoma and extensive metastatic disease, with a…
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Podoplanin and Selected Cancer Stem Cell or Stemness-Associated Markers in Oral Epithelial Dysplasia: A Structured Narrative Review of Their Role in Malignant Transformation and Risk Stratification
Background: Oral potentially malignant disorders (OPMDs) comprise clinically and histologically heterogeneous lesions associated with an increased risk of oral squamous cell carcinoma (OSCC). Histopathological grading of oral epithelial dysplasia (OED) remains central to risk estimation but has…
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The Transcaval AngioVac Aspiration of a Left Subclavian Artery Intimal Sarcoma Masquerading as Arterial Thrombosis: A Case Report
Background and Clinical Significance: Intimal sarcoma is a rare, aggressive malignancy of the large arteries that grows within the vessel lumen and frequently mimics thromboembolic disease, leading to diagnostic delay. Flow restoration and tissue biopsy are both difficult if the tumour occupies a…
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Pediatric Eosinophil-Predominant Collagenous Gastritis: From Conventional Therapy to Dupilumab: A Case Report
Background and Clinical Significance: Collagenous gastritis (CG) is a rare disorder characterized by subepithelial collagen deposition, typically presenting in children with iron deficiency anemia (IDA) and abdominal pain. Its pathogenesis remains unclear, and no standardized treatment exists. Case…
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A Transient Left Atrial Appendage Filling Defect During Anticoagulation Interruption After Ischemic Stroke with Progressive Hemorrhagic Transformation: A Case Report
Background and Clinical Significance: Anticoagulation timing after atrial fibrillation (AF)-related ischemic stroke is uncertain when hemorrhagic transformation (HT) is progressive. Although early direct oral anticoagulant (DOAC) initiation is supported in selected patients, evidence is limited for…
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A Rare Case of Neonatal-Onset Diarrhea Due to Congenital Tufting Enteropathy: Clinical, Histopathological, and Genetic Insights
Background and Clinical Significance: Congenital tufting enteropathy (CTE), or autosomal recessive congenital diarrhea type 5 (DIAR5), is a rare intestinal epithelial disorder characterized by severe neonatal-onset watery diarrhea, failure to thrive, and intestinal failure. Most cases are caused by…
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Metastatic Melanoma with an Unknown Primary Origin Presenting with Postmenopausal Bleeding: A Case Report
Background and Clinical Significance: Melanoma is predominantly a cutaneous malignancy, whereas metastatic involvement of the endometrium is exceptionally rare. Melanoma of unknown primary (MUP) accounts for a small portion of such cases. Patients typically present with abnormal uterine bleeding…
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Presentation and Management of High-Grade Pancreatic Injuries: Case Series
Background: Trauma surgeons face a challenge in the management of high-grade pancreatic injuries (HGPIs), as optimal strategies remain controversial. HGPIs are uncommon and difficult to manage due to dynamic trauma physiology and complications from the injury and management. We aimed to evaluate…
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Giant Recurrent Retroperitoneal and Ischioanal Lymphangioma in an Adult: A Case Report
Background and Clinical Significance: Lymphatic malformations (cystic lymphangiomas) are rare benign tumors in adults, with retroperitoneal and ischioanal involvement being exceptionally uncommon. These lesions often present significant surgical challenges because of their infiltrative growth…
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A Novel ABCC8 Variant in an Adult with Hyperinsulinemic Hypoglycemia Suggestive of Congenital Hyperinsulinism: A Case Report
Background and Clinical Significance: Congenital hyperinsulinism (CHI) is a disorder involving excessive insulin secretion due to mutations in the insulin regulation pathways. Patients are typically diagnosed during infancy following recurrent hypoglycemic events, which may lead to irreversible…
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Bronchial Ligation as a Temporizing Procedure for Hemoptysis Caused by Acute Type B Aortic Dissection Rupturing into the Lung with Subsequent TEVAR: A Case Report
Background and Clinical Significance: Hemoptysis caused by acute type B aortic dissection rupturing into the lung is rare but life-threatening; Case Presentation: An 81-year-old man receiving maintenance hemodialysis developed hemoptysis due to an aortobronchial fistula involving the left upper…
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Epstein–Barr Virus-Induced Acute Pancreatitis—A Case Report and a Review of Literature
Background and Clinical Significance: Epstein–Barr virus (EBV) is a common infection that rarely causes acute pancreatitis. EBV-associated acute pancreatitis is an uncommon but potentially serious complication that may result from direct viral invasion of pancreatic tissue or immune-mediated…
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Cancer-Associated Retinopathy Presenting with Paraneoplastic Cerebellar Degeneration in Tonsillar Squamous Cell Carcinoma: A Case Report
Background and Clinical Significance: Cancer-associated retinopathy (CAR) is a rare paraneoplastic autoimmune retinopathy caused by antibodies targeting tumor antigens with cross-reactivity to retinal proteins. Paraneoplastic cerebellar degeneration (PCD) results from autoimmune injury to…
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Imatinib-Associated Interstitial Lung Disease with a Fibrotic NSIP Pattern on Transbronchial Lung Cryobiopsy: A Case Report and Review of the Literature
Background and Clinical Significance: Interstitial lung disease (ILD) is an uncommon but potentially serious complication of imatinib. Its histopathological characterization has so far relied on surgical biopsy or transbronchial forceps sampling, and no case characterized by transbronchial lung…
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Staged Treatment of Cutaneous Calcinosis with Polylactic Acid Matrix, Negative Pressure Wound Therapy and Skin Grafting: A Case Report
Background and Clinical Significance: Dystrophic calcinosis cutis involves calcium deposition in damaged or chronically inflamed tissues despite normal calcium and phosphate metabolism. Although typically associated with systemic sclerosis and dermatomyositis, it is rare in rheumatoid arthritis…
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Descemet Membrane Detachment Presenting as Graft Edema After Arcuate Keratotomy in an Eye with Previous Penetrating Keratoplasty—A Case Report
Introduction and Clinical Significance: Descemet membrane detachment (DMD) is an uncommon but potentially vision-threatening complication of anterior segment surgery. Although immune-mediated graft rejection is a recognized cause of postoperative graft edema following arcuate keratotomy (AK) in…
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A Stepwise Technique for Retrieval of a Seized and Stripped Dental Implant Cover Screw: A Case Report
Background and Clinical Significance: In two-stage implant treatment the cover screw must be removed at second-stage surgery. Removal is occasionally prevented by cold welding or seizure. When the drive slot is damaged by escalating torque, no standard salvage protocol has been established, and the…
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Left Renal Vein Pseudo-Fenestration
We describe a rare case of LRV pseudo-fenestration in a 68-year-old female identified on contrast-enhanced multidetector computed tomography. Unlike true fenestration, in which a single vessel splits and reunites, this pseudo-fenestration resulted from the convergence of two distinct hilar venous…
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Oral Pemphigus in Children and Adolescents: A Narrative Review of Published Case Reports
Background: Pemphigus is a rare group of autoimmune blistering diseases characterized by autoantibody-mediated loss of keratinocyte adhesion, resulting in intraepithelial blister formation involving the skin and mucous membranes. Pemphigus Vulgaris (PV) is the most common type of pemphigus, which…