501 results
Showing 1–20 · 0.10 seconds · RSS
JOR Spine
Scopus
ISSN 2572-1143 · Wiley · 501 articles in the index
-
Journal Article
Alignment Between Large Language Models and Consensus in Endoscopic Spinal Disc Surgery: A Comparative Analysis Against the Neurocore‐SENSED
ABSTRACT Background The Neurocore‐SENSED framework, derived from a three‐round modified Delphi process involving 77 international spine surgeons, provides a structured reference standard for reporting in endoscopic spine surgery (ESS) for disc disease. The ability of large language models (LLMs) to…
-
Journal Article
Surviving the Nucleus Pulposus Desert: Next‐Generation Strategies for Intervertebral Disc Cell Therapy
ABSTRACTBackgroundLow back pain remains the leading cause of disability worldwide, with intervertebral disc degeneration representing a major biological contributor. Although cell‐based therapies have shown promise in preclinical models, clinical translation has yielded modest and inconsistent…
-
Journal Article
Fetal Pathogenesis of Scoliosis Suggested by Asymmetry of Gene Expression in Paravertebral Muscles
ABSTRACT Background The dysfunction of paravertebral muscles may contribute to the development of idiopathic scoliosis. Several candidate genes have been linked to scoliosis, but the underlying mechanisms and cell types remain unclear. Methods We initially included 40 idiopathic scoliosis cases and…
-
Journal Article
Growth Plate Morphogens as Potential Modulators of Cellular Tissue Remodeling by Annulus Fibrosus Cells
ABSTRACT Background Adolescent Idiopathic Scoliosis (AIS) is a spinal deformity of unknown etiology that begins in the intervertebral disc and emerges during pubertal growth. In the vertebral growth plate, adjacent to the disc, powerful growth plate morphogens (GPMs) modulate this growth. We…
-
Journal Article
The Effect of Single Level and Multilevel Cervical Fusion on Adjacent Segment Motion: A Biomechanical Analysis
ABSTRACT Background Cervical arthrodesis is a common surgical technique utilized to treat many cervical spinal pathologies. The risk of re‐operation due to symptomatic adjacent segment disease (ASD) remains steady, and the cause of ASD, whether rigid fixation or disease progression, remains…
-
Journal Article
The Effect of Head‐Forward Posture on Lower Neck Loads and Dislocation Risk in Head‐First Impact: A Computational and Experimental Investigation
ABSTRACT Background Subaxial cervical facet dislocation (CFD) is a severe neck injury associated with head‐first impact (HFI). However, CFD has not been reliably reproduced in experimental or numerical studies, limiting understanding of its underlying mechanics. This study quantified the influence…
-
Journal Article
A Novel Gelatin Hydrogel‐Based Drug‐Delivery System Promotes Antimicrobial Efficacy in a Pyogenic Spondylodiscitis Rat Model
ABSTRACT Background Spondylodiscitis/spondylitis is an intractable disease requiring long‐term intravenous antibiotics administration. However, drug delivery is greatly restricted because of the avascular nature in the intervertebral disc, which not only delays recovery but increases antimicrobial…
-
Journal Article
Are Ceramic Cages an Option for Lumbar Interbody Fusion? A Comparative Biomechanical Numerical Study
ABSTRACT Background The treatment of severe disc pathologies through lumbar interbody fusion (LIF) involves the insertion of an interbody cage into the degenerated disc space, together with a supporting fixation system. Conventional cage materials, such as Ti6Al4V and PEEK, present several…
-
Journal Article
Galectin‐4: A Novel Mediator of Human Intervertebral Disc Degeneration
ABSTRACT Background Intervertebral disc (IVD) degeneration is associated with severe clinical symptoms including chronic back pain. Galectins are a family of carbohydrate‐binding proteins, some of which can induce functional disease markers in IVD cells and other musculoskeletal tissues. Galectin‐4…
-
Journal Article
My Love Story With HIFs in the Disc: A Journey to the Humboldt Research Award
ABSTRACT The intervertebral disc is a prime example of tissue adaptation to metabolic and mechanical extremes. As the largest avascular organ in the human body, the disc and the central nucleus pulposus (NP) endure constant compressive loading while sustaining a hypoxic, relatively acidic, and…
-
Journal Article
Assessment of Vertebral Body Bone Quality in Adolescent Idiopathic Scoliosis (AIS) Using Micro‐CT, qBEI, and Nanoindentation—A Case Study
ABSTRACT Background Adolescent idiopathic scoliosis (AIS) is the most common three‐dimensional spinal deformity, predominantly affecting females aged 10–16 years. Although no single etiological factor has been definitively identified, alterations in bone quality and biomechanical properties have…
-
Journal Article
A Deep Learning–Based Multimodal Fusion Model for Predicting Bone Cement Leakage in Percutaneous Kyphoplasty: Development and Validation
ABSTRACT Background There is a lack of intelligent methodologies that effectively integrate multimodal information to predict bone cement leakage (BCL) during percutaneous kyphoplasty (PKP). This study aimed to develop and validate a deep learning (DL)–based multimodal fusion model that…
-
Journal Article
Human In Vivo Disc Mechanics in Flexion, Extension, and Diurnal Loading With Aging and Degeneration
ABSTRACT Background The intervertebral disc serves a critical role in spine function, but with aging and degeneration the disc undergoes changes that alter disc mechanics, and degeneration is often implicated in low back pain. The objective of this study was to quantify and evaluate the impact of…
-
Journal Article
Lost in Translation: Why Biologic Therapies for Intervertebral Disc Degeneration and Low Back Pain Have Not Reached the Clinic (Yet)
ABSTRACT Background Biologic therapies for intervertebral disc degeneration (IDD) have shown strong preclinical promise, yet clinical translation for discogenic low back pain (LBP) remains limited. This gap reflects the inconsistent relationship between degeneration and pain, compounded by…
-
Journal Article
Transgenic Conversion of Omega‐6 to Omega‐3 Fatty Acids via fat‐1 Reduces Obesity‐Related Intervertebral Disc Degeneration
ABSTRACT Introduction Low back pain is a leading cause of disability, largely due to intervertebral disc (IVD) degeneration. Obesity is a risk factor for IVD degeneration and promotes the release of pro‐inflammatory cytokines from adipocytes, leading to inflammation and triggering catabolic…
-
Journal Article
Large Language Models in Preclinical Spine Research: A Scoping Review and Expert Perspective on Evidence‐Aware Experimental Workflows
ABSTRACT Background Preclinical spine research is limited by heterogeneous experimental reporting, fragmented documentation, and barriers to reproducibility and translational alignment. Large language models (LLMs) and related artificial intelligence (AI) technologies may support semantic…
-
Journal Article
A Porcine Model of Intervertebral Disc Injury Recapitulates Human Discogenic Pain Via Notochordal Cell Loss and Pain‐Inducing Nucleus Pulposus Cell Emergence
ABSTRACT Background Lower back pain (LBP) is one of the most common causes of disability, with up to 40% of LBP cases attributed to intervertebral disc (IVD) degeneration. While small animal models are widely used to study IVD degeneration and LBP, the small size of their IVDs limits translational…
-
Journal Article
Spatial Investigation of Facet Joint Cartilage Properties Reveals Specific Structure–Function Relationships
ABSTRACT Background Facet joints are highly susceptible to osteoarthritis, which can manifest in distinct patterns of cartilage degeneration across the facet joint surfaces. Understanding how cartilage structure translates into functional properties of the tissue may help to identify regions that…
-
Journal Article
Semi‐Automated μCT‐Based Modeling of Vertebral Bony Endplate Microporosity and Mechanical Properties: Linking Microstructure to Inferred Mechanical Performance
ABSTRACT Background The vertebral bony endplate (BEP) plays a role in regulating both mechanical load transfer and nutrient transport to the intervertebral disc, functions strongly influenced by its microstructural porosity. Variations in porosity impact bone strength, elasticity, and solute…
-
Journal Article
Intradiscal Cutibacterium acnes Sustains Modic Type 1‐Like Lesions Over Time in a Rat Lumbar Endplate Injury Model
ABSTRACT Background Modic changes (MC) are painful vertebral bone marrow lesions. Three interconvertible types represent different pathology stages with MC1 being the most painful, MC2 less painful, and MC3 asymptomatic. Bacterial (Cutibacterium acnes (C. acnes)–mediated) and non‐bacterial…