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Cancer Reports
Scopus
ISSN 2573-8348 · Wiley · 1,397 articles in the index
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Journal Article
Clinical Course and Risk Factors of Lenvatinib‐Related Hypothyroidism in Hepatocellular Carcinoma: A Retrospective Cohort Study
ABSTRACT Background Lenvatinib‐related hypothyroidism occurs in 16%–22% of patients with hepatocellular carcinoma and may affect treatment management. Previous studies have reported elevated serum thyroid stimulating hormone (TSH) levels despite levothyroxine therapy, indicating the need for…
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Journal Article
A Pan‐Subtype Fatty Acid Metabolic Signature Reveals Universal Prognostic Stratification in Breast Cancer
ABSTRACT Background Breast cancer exhibits profound molecular heterogeneity. Each subtype is characterized by distinct biological features, therapeutic responses, and prognostic outcomes. However, a unifying feature across most breast cancer subtypes is an adipocyte‐enriched microenvironment…
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Journal Article
Efficacy and Safety of Different Neoadjuvant Treatment Regimens in Locally Advanced Squamous Head and Neck Cancer
ABSTRACT Background Head and neck squamous cell carcinoma (HNSCC), which constitutes approximately 90% of all head and neck cancers, represents a significant global health burden. A concerning trend is the rising incidence, particularly among younger populations, which has been partly attributed to…
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Journal Article
Outcomes and Management of Dermatologic Toxicity Following Enfortumab Vedotin Rechallenge in Patients With Metastatic Urothelial Carcinoma: A Retrospective Single‐Center Study
ABSTRACT Background Enfortumab vedotin (EV) has demonstrated clinical benefits as a third‐line monotherapy after chemotherapy and immune checkpoint inhibitors and is currently established, in combination with pembrolizumab, as a first‐line standard therapy for metastatic urothelial carcinoma (mUC)…
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Journal Article
Real‐World Outcomes With Low‐Dose Dasatinib (50 mg) in Imatinib‐Resistant Chronic Myeloid Leukemia in Chronic Phase: A Retrospective Analysis of Efficacy and Safety
ABSTRACT Background Dasatinib, a potent second‐generation tyrosine kinase inhibitor (TKI), is highly effective in chronic myeloid leukemia in chronic phase (CML‐CP) resistant to imatinib at standard dosing (100 mg daily), but is often limited by adverse events. Emerging evidence suggests low‐dose…
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Journal Article
Significance and Correlation Analysis of Folate Receptor‐Positive Circulating Tumor Cells (FR + CTC) in Colorectal Cancer Patients
ABSTRACT Background To investigate the significance of detecting folate receptor‐positive circulating tumor cells (FR + CTC) in colorectal cancer patients and to analyze their correlation with the expression of conventional tumor markers (CEA, CA199, CA125). Methods and Results A retrospective…
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Journal Article
Frailty in Patients With Hematologic Malignancies and Patients Undergoing Hematopoietic Stem Cell Transplantation: A Systematic Review
ABSTRACT Background Hematopoietic stem cell transplantation (HSCT) is associated with significant morbidity and mortality. Frailty further increases these risks in recipients of HSCT. This systematic review analyzes the extent of frailty in patients with hematologic malignancies and patients…
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Journal Article
Maxillofacial Squamous Cell Carcinoma With Cervical Metastasis and Tuberculous Lymphadenitis: Diagnostic Dilemmas and Clinical Insights
ABSTRACT Background Maxillofacial squamous cell carcinoma (SCC) typically metastasizes to lymph nodes, yet coexisting tuberculous lymphadenitis is extraordinarily rare, posing diagnostic challenges. Case A 68‐year‐old female with right maxillofacial SCC and ipsilateral lymphadenopathy underwent…
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Journal Article
Challenges and Limitations of Sequential MET‐TKI Therapy in METex14‐ Positive NSCLC With a Focus on Non‐ILD Toxicities: A Case Report
ABSTRACT Background Nonsmall cell lung cancer (NSCLC) with mesenchymal‐epithelial transition exon 14 skipping mutation (METex14) represents a distinct molecular subtype with limited therapeutic options. Selective MET tyrosine kinase inhibitors (MET‐TKIs) such as tepotinib, capmatinib, and…
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Journal Article
Venetoclax‐Based Therapy for Early Relapse in Acute Myeloid Leukemia After Allogeneic Hematopoietic Stem Cell Transplantation: A Case Report and Minireview
ABSTRACT Background Refractory/relapsed acute myeloid leukemia (R/R‐AML) typically exhibits resistance to conventional chemotherapy, resulting in a poor overall therapeutic outcome. Salvage allogeneic hematopoietic stem cell transplantation (allo‐HSCT) is the primary treatment option in such…
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Journal Article
Transmembrane Protein TMEM59L Modulates 5‐FU Resistance via PTPRN‐Mediated DNA Damage Repair in Colorectal Cancer
ABSTRACT Background Chemotherapy resistance in colorectal cancer (CRC) is often mediated by enhanced DNA damage repair (DDR). Transmembrane protein TMEM59L is implicated in cancer progression, but its role in CRC chemoresistance is unclear. We investigated whether TMEM59L regulates 5‐fluorouracil…
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Journal Article
How Do Patient Demographics and Socioeconomic Disadvantage Impact Clinical Presentation, Surgical Outcomes, and Survival for Upper Extremity Soft Tissue Sarcoma?
ABSTRACT Background Soft tissue sarcomas (STS) of the upper extremity (UE) are uncommon and may require complex surgical management. Socioeconomic disadvantage, race/ethnicity, sex, and marital status may influence presentation, surgical complexity, local recurrence (LR), and overall survival (OS)…
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Journal Article
The Role of RANBP3L in Pan‐Cancer With Its Significance in Hepatocellular Carcinoma
ABSTRACT Background RAN binding protein 3‐like (RANBP3L), a member of the Ran‐binding protein family, has been linked to various cellular functions, but the role in cancer remains underexplored. In this research, we assessed the diagnostic and prognostic value of RANBP3L in pan‐cancer, especially…
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Journal Article
Immunoinformatics‐Based Multi‐Epitope Vaccine Targeting Helicobacter Pylori
ABSTRACT Background The rising global incidence of Helicobacter pylori‐related diseases, particularly gastric cancer, underscores the urgent need for effective preventive vaccines, motivating the exploration of innovative immunoinformatic strategies to address this public health challenge. Aims The…
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Journal Article
Adenoid Cystic Carcinoma of the Breast: Clinicopathological Features, Therapy Strategy, and Prognosis
ABSTRACT Background Adenoid cystic carcinoma (ACC) of the breast is a special subtype of breast cancer. Aims This study aimed to systematically characterize the clinicopathologic features, treatment patterns, and prognostic indicators of breast ACC, with the overarching goal of enhancing clinical…
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Journal Article
Psychological Resilience and Associated Factors in Cancer Patients: A Cross‐Sectional Analysis
ABSTRACT Background Cancer remains one of the leading global health problems, with treatments that can compromise patients' quality of life. Aims This study aimed to determine the prevalence and characteristics of resilience in cancer patients and to analyze the influence of psychological and…
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Journal Article
Breast Health Training Program for Traditional Healers: A Pathway to Early Breast Cancer Detection in Tanzania
ABSTRACT Background In sub‐Saharan Africa, traditional healers often serve as primary healthcare providers and are the first point of contact for patients. Given this, they are uniquely positioned to aid in early breast cancer detection. To evaluate this, we implemented a breast cancer training…
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Journal Article
Identification of Potential Ferroptosis Biomarkers in Multiple Myeloma via WGCNA and Experiments
ABSTRACT Introduction Multiple myeloma is a common malignant tumor of the hematologic system, and genetic alterations play a crucial role in its occurrence and development. Ferroptosis is an oxidative and iron‐dependent programmed cell death, which has a strong correlation with tumor development…
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Journal Article
Impact of a Reproductive Health Survivorship Care Plan on Fertility, Pregnancy Concerns, and Accessing Reproductive Healthcare Among Young Nulliparous Breast Cancer Survivors
ABSTRACT Background Young patients with breast cancer frequently receive chemotherapy and/or endocrine therapy that adversely affect ovarian function, leading to fertility, pregnancy, and other reproductive health concerns. Despite available evidence‐based management strategies, dissemination to…
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Journal Article
Predictors of Response to Imatinib Therapy and Long‐Term Outcomes in Paediatric and Adolescent Patients With Chronic Myeloid Leukaemia
ABSTRACT Background Chronic myeloid leukaemia (CML) is an infrequent myeloproliferative neoplasm in the paediatric population as compared to adults. Despite vast progress in understanding the disease biology and therapy of CML‐chronic phase (CML CP), the applicability of risk scoring systems in…
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