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Pediatric Investigation
Scopus
ISSN 2574-2272 · Wiley · 367 artikel di indeks
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Artikel Jurnal
Treatment of pediatric epilepsy
ABSTRACT Pediatric epilepsy is a neurological disorder arising from various etiologies, including structural, genetic, immune, infectious, metabolic, and unknown causes. Anti‐seizure medications remain the primary treatment; however, in cases of drug‐resistant epilepsy, surgical interventions…
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Artikel Jurnal
The ketogenic diet alters microbiome‐metabolome profiles to improve West syndrome therapy
ABSTRACT Importance The ketogenic diet (KD) is effective in managing epilepsy, particularly West syndrome (WS); however, the role of gut microbiome (GM) and metabolome in its efficacy remains unclear. Understanding these mechanisms could optimize the KD for WS treatment. Objective To identify…
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Artikel Jurnal
Next‐generation sequencing in newborn screening: Current status, challenges, and future perspectives
ABSTRACT Newborn screening (NBS) is a key public health intervention that improves children's health outcomes by enabling precise intervention through the early detection of hereditary and metabolic diseases. With advances in genomic technology, genomic NBS (gNBS) is gradually overcoming the…
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Artikel Jurnal
Chinese guideline for the prevention and control of complications associated to umbilical venous catheterization in neonates (2025)
ABSTRACT This guideline aims to standardize the prevention and management of complications related to umbilical venous catheterization (UVC). It addresses nine clinical questions, categorized into three sections: (1) questions concerning UVC‐related infection, (2) catheter position, and (3) UVC…
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Artikel Jurnal
Therapeutic potential of tetrahydroxylated bile acids in reducing liver injury: Insights from the Zfyve19−/− mouse model
ABSTRACT Importance The production of tetrahydroxylated bile acids (THBAs) is associated with better prognosis in some cholestatic patients as well as in multidrug resistance protein 2 knockout (Mdr2−/−) mice. However, it remains unclear whether this protective effect is specific to Mdr2−/− mice…
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Artikel Jurnal
CRPPA exon 6–9 deletion as a founder mutation in Chinese patients with dystroglycanopathy
ABSTRACT Importance Dystroglycanopathies (DGPs) are a group of muscular dystrophies with abnormal glycosylation of dystroglycan. CRPPA is a gene associated with DGPs. Understanding the genetic basis, genotype–phenotype correlations, and population‐specific mutations is crucial for accurate…
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Artikel Jurnal
Effectiveness and safety of tocilizumab combined with different high‐dose methylprednisolone regimens for acute necrotizing encephalopathy in children
ABSTRACT Importance Acute necrotizing encephalopathy (ANE) is a rare but life‐threatening pediatric neurological disorder characterized by rapid progression and high mortality. Tocilizumab, an interleukin‐6 receptor antagonist, combined with high‐dose methylprednisolone [MP, ≥20 mg/(kg·day)], may…
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Artikel Jurnal
Interaction analysis of non‐bacterial respiratory pathogens during and after the coronavirus disease 2019 pandemic in two cities along the eastern coast of China
ABSTRACT Importance The coronavirus disease 2019 (COVID‐19) pandemic and associated non‐pharmaceutical interventions (NPIs) have significantly altered the epidemiology of respiratory pathogens. Understanding the interactions between non‐bacterial respiratory pathogens is crucial for clinical…
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Artikel Jurnal
Prevalence of non‐alcoholic fatty liver disease and its association with different combinations of weight status and metabolic abnormalities in children aged 6–18 years
ABSTRACT Importance Obesity and non‐alcoholic fatty liver disease (NAFLD) guidelines recommend screening for NAFLD in children with obesity or overweight plus metabolic abnormalities. However, which metabolic factor is more closely associated with NAFLD in children with overweight or obesity…
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Artikel Jurnal
Large‐language‐models for pediatric diagnosis: Performance evaluation using real‐world clinical notes from common and rare cases
ABSTRACT Importance Rigorous evaluation of large language models (LLMs) in pediatric diagnosis using authentic clinical presentations remains limited, particularly regarding response consistency and rare disease recognition. Objective To evaluate the diagnostic accuracy, consistency, and clinical…
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Artikel Jurnal
Kaposiform hemangioendothelioma: Diagnosis and treatment
ABSTRACT Kaposiform hemangioendothelioma (KHE) is a rare borderline vascular tumor that occurs primarily during infancy and childhood. The tumor typically originates in the skin and exhibits invasive growth into deeper tissues, often manifesting as a firm, poorly defined purplish‐red mass. Cases of…
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Artikel Jurnal
A comprehensive parent training program for parents of neurodivergent children with pathological demand avoidance: The Paradigm Shift Program® Pilot Study
ABSTRACT Importance Although pathological demand avoidance (PDA; also known as “extreme” or “persistent” demand avoidance and persistent drive for autonomy) was first described in 1980 as a distinct behavioral profile among a subgroup of children with autism spectrum disorder, there is limited…
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Artikel Jurnal
Evidence‐based guideline for clinical practice in the diagnosis, treatment, management, and prevention of recurrent wheezing in infants and toddlers in China
ABSTRACT Wheezing is a common respiratory symptom in infants and toddlers, and recurrent wheezing is a significant respiratory disorder affecting this age group. Given the multifactorial etiology of recurrent wheezing, clinical practice lacks standardized diagnostic and therapeutic protocols…
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Artikel Jurnal
Cardiac resynchronization therapy and pulmonary artery banding in advanced heart failure infants with left ventricular dilated cardiomyopathy and left bundle branch block
ABSTRACT Importance Infantile dilated cardiomyopathy (DCM) associated with left bundle branch block (LBBB) is a rare but life‐threatening condition, especially when severe heart failure is present. Identifying effective solutions to improve the prognosis is crucial. Objective This study aims to…
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Artikel Jurnal
Pediatric spinal ependymomas: Long‐term surgical outcomes in a cohort of 61 cases
ABSTRACT Importance Spinal ependymomas are rare in the pediatric population, with limited evidence of long‐term outcomes and predictors of recurrence. Objective To analyze clinic‐radiological features, therapeutic methods, and long‐term outcomes in a pediatric cohort. Methods We retrospectively…