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Life Science Alliance
Scopus
ISSN 2575-1077 · Life Science Alliance LLC · 1.813 artikel di indeks
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Artikel Jurnal
Murine IL-2 outperforms human IL-2 in supporting the survival of naïve mouse CD8 T cells in vitro
Murine IL-2 promotes the survival of naïve mouse CD8 T cells in vitro compared with human IL-2 and induces a distinct expression pattern of IL-2 receptors in activated CD8 T cells. Much of the immunology community relies on human IL-2 to support murine CD8 T-cell expansion in vitro. Although human…
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Proteomics of heterogeneous megakaryocytes identifies JI051 as an enhancer of platelet biogenesis
This study establishes a proteomics platform to elucidate megakaryocyte heterogeneity and identifies JI051 as a compound that enhances platelet-like particle generation with bioproduction potential. Induced pluripotent stem cell-derived immortalized megakaryocyte cell lines (imMKCLs) exhibit…
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Fetal growth restriction leads to prolonged nephrogenesis and gene dysregulation in the adult kidney
A mouse model of fetal growth restriction demonstrates prolonged nephrogenesis and gene dysregulation in adulthood. These findings link impaired kidney development to disease risk, highlighting late gestational and early postnatal periods as therapeutic windows during active nephrogenesis to…
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RAF1 scaffold integrity shapes chemogenetic degradation outcomes in KRAS-driven lung cancer models
This study shows that an N-terminal degradation tag can alter RAF1 function before protein removal, highlighting the need to validate tagged proteins in disease models. Scaffold integrity is essential for the activity of proteins that function through protein–protein interactions rather than…
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Transcription termination factor 2 (TTF2) prevents premature rRNA synthesis during mitotic exit
TTF2 restrains RNA Polymerase I reactivation at mitotic exit, and its loss triggers premature rRNA synthesis and nucleolar fragmentation. Mitosis poses major challenges to transcription, as gene expression is silenced and must be restored upon mitotic exit. These processes are regulated by…
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A selective inhibitor reveals roles for LONP1 in mitochondrial proteostasis and OXPHOS dependencies
PZL-26 targets LONP1 with nanomolar potency and on-target cellular activity, revealing OXPHOS and mitochondrial gene expression as key survival dependencies. Lon protease 1 (LONP1) is a conserved hexameric protease implicated in mitochondrial disorders and cancer progression. In this study, we…
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Human-biased MEIS1 expression by a promoter noncoding RNA regulates neural stem cell proliferation
Conserved MEIS1 drives human cortical expansion. A human-specific noncoding RNA regulates MEIS1 to coordinate primary cilia morphology, preserving neural progenitor proliferation Whereas primate-specific genes are known to drive human evolution, conserved genes also play critical roles in defining…
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The noncoding RNA GRAS1 interacts with NKAP and protects against DNA damage and cell death
This study uses a combination of molecular biochemistry and cell biology approaches to identify a novel function for a noncoding RNA and protein interaction in promoting human cell survival. Noncoding RNA (ncRNA) gene products may be involved in diverse biological processes. We find that the growth…
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Mechanical memory of confinement pressure governs expansion size in epithelial monolayers
Confined epithelial tissues encode pressure history into cell-cycle activity, enabling colonies of different densities to converge on the same size and density upon release. Epithelial tissues undergo rapid expansion during development, repair, and morphogenesis, yet how tissue-scale growth is…
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Legionella effector RavH is a tandem WH2-like domain–containing PI(3)P-dependent actin nucleator
Legionella pneumophila effector RavH acts as a membrane-dependent actin nucleator on organelles enriched with PI(3)P, revealing a mechanism that may support early vacuole dynamics during infection. Legionella pneumophila infects and replicates within protozoa and macrophages in a specialized…
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Structural interplay of the redox co-chaperone CnoX to GroEL/ES chaperonin
Cryo-EM structures reveal how the redox co-chaperone CnoX is accommodated during the GroEL reaction cycle and how GroES binding remodels the apical domains to promote CnoX release. Protein folding by the bacterial chaperonin GroEL/ES relies on ATP-driven conformational cycles that promote substrate…
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Clonal LIMD1 loss drives PD-L1 immune evasion via ARIH1-dependent ubiquitination in lung cancer
Lung cancer tumour suppressor LIMD1 regulates the expression of a key immune checkpoint protein PD-L1. This occurs via loss of miRNA-mediated regulation of PD-L1 or ARIH1-dependent PD-L1 ubiquitination. Low LIMD1 expression was enriched among responders to immune checkpoint blockade. LIMD1, a…
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Bruno 1 remodels P-bodies to protect select mRNAs during the early ER stress response
During Drosophila melanogaster oogenesis, activation of the unfolded protein response induces ATF4-dependent Bruno 1 expression, reshaping P-body architecture and composition to safeguard specific mRNAs from stress-induced degradation before stress granule formation. P-bodies are cytoplasmic…
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A cardiac-related, promoter-proximal, regulatory element shapes chromatin and JAG1 transcription
This study identifies R7 as a promoter-proximal element that supports JAG1 transcription by coordinating local chromatin contacts and regulatory features. The Jagged1 ( JAG1 ) gene is essential for cardiac development, yet its tissue-specific transcriptional regulation remains poorly understood. In…
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The transcriptional cortical response to daily torpor in Phodopus sungorus
Using nuclei RNA-seq from Djungarian hamster cortex across seasonal and metabolic states, we show non-neuronal cells adapt seasonally through circadian genes, whereas neurons reprogramme during torpor, enriching RNA catabolism and revealing transcriptional divergence from hypothalamus during…
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Fishing with two lines: a hybrid approach to spatial transcriptomics discovery
This study serves as a technical proof of concept demonstrating the hybridization and co-detection of both low- and high-plex probe chemistries on a single Xenium spatial transcriptomics slide with 17 hLung samples. Spatial transcriptomics faces a trade-off between the number of genes assayed and…
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Investigating the role of CpG islands and DNA methylation at 3′UTRs in cancer
This study characterises CpG islands at 3′UTRs as highly conserved, frequently methylated, and linked to cancer-related gene regulation. DNA methylation is one of the most important epigenetic processes that regulates gene expression. Although the human genome is predominantly methylated, CpG-rich…
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RAFTER: a releasing factor tethered RNA editing system for quantifying mRNA translation
RAFTER combines an RNA editing enzyme with a translation termination factor to selectively label translated RNAs, enabling accurate and scalable translation profiling with single-cell compatibility. Measurement of mRNA translation level has heavily relied on quantifying the amount of…
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Lack of evidence for transcription-to-RNA maturation lags across G1-to-G2-phase boundary in fibroblasts
In human fibroblasts, transcription and RNA accumulation are temporally concordant across the cell cycle, challenging the model of extensive transcription-to-maturation lags during the cell cycle. Cell-cycle dynamics of gene expression are fundamental to life, yet their mechanistic basis remains…
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SATB1 preserves CD4 + T-cell fidelity and establishes Treg function in antitumor immunity
SATB1 preserves CD4 + T-cell lineage fidelity by repressing Foxp3 in conventional T cells and is essential for establishing FoxP3-mediated gene repression in regulatory T cells. Deleting SATB1 disrupts Treg suppressive function, unleashing potent antitumor immunity. The genome organizer special…
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