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International Journal of Medical Biochemistry
Scopus
ISSN 2587-2362 · KARE Publishing · 28 artikel di indeks
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Artikel Jurnal
Effects of flavonoids on cholesterol efflux capability
Reverse cholesterol transport (RCT), which plays a critical role in the export of cholesterol from peripheral cells, is one of the processes employed in the management and treatment of atherosclerosis. RCT requires cholesterol efflux from macrophages in the subintima of the vessel wall. ATP-binding…
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Artikel Jurnal
Effects of electronic cigarettes on oxidative stress markers in the rat kidney tissues
INTRODUCTION: Electronic cigarettes (e-cigarettes) are an alternative to traditional cigarettes. Although numerous studies have been conducted regarding the effects of traditional cigarettes on oxidative stress biomarkers in the kidney, there are only a few studies on the effects of e-cigarettes…
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Comparison of inflammation markers in different severities of COVID-19 disease
INTRODUCTION: We retrospectively analyzed COVID-19 patients for clinical and hematologic features and tried to define the most appropriate markers to diagnose and predict the severity. METHODS: This is a retrospective cross-sectional study. All 4443 patients included were diagnosed with reverse…
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Comparison of Diagon Coag XL and Cobas t 511 analyzers
INTRODUCTION: We compared prothrombin time (PT), activated partial thromboplastin time (aPTT), fibrinogen, and Ddimer test results measured using the Diagon Coag XL coagulation analyzer with Cobas t 511 analyzer. METHODS: Imprecision studies were performed for the PT, aPTT, fibrinogen, and D-dimer…
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Importance of detecting hyperlipidemia in children and adolescents to manage cardiovascular risk: A cross-sectional study
INTRODUCTION: As childhood and adolescence are the periods when cardiovascular risk factors begin to emerge, this study aimed to investigate the serum lipid profiles of the pediatric population in age- and sex-specific partitions. METHODS: The serum lipids were measured in 9613 pediatric samples…
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Monocyte to high-density lipoprotein and derived neutrophil to lymphocyte ratio in patients with acute pancreatitis are associated with the severity of the disease
INTRODUCTION: We aimed to compare the severity of the disease with derived neutrophil to lymphocyte ratio (DNLR) and monocyte to high-density lipoprotein ratio (MHR) in patients with acute pancreatitis (AP). METHODS: This retrospective study included 52 patients with Ranson 0, 57 patients with…
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Evaluation of the relationship between C-Reactive Protein/Albumin Ratio and Hospitalization in Novel Coronavirus disease-19 (COVID-19)
INTRODUCTION: Coronavirus disease 2019 (COVID-19), a global pandemic with catastrophic consequences for healthcare systems causing serious respiratory illness, was first reported in China. Early identification of severe illness is critical for controlling it and improving the prognosis of patients…
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Identification of key genes and pathways for cholangiocarcinoma using an integrated bioinformatics analysis
INTRODUCTION: The scope of this study was to identify potential genes as a promising biomarker in diagnosing cholangiocarcinoma (CCA) or differentiating the subtypes of CCA. In this study, we used Gene Expression Omnibus (GEO)-NCBI data sets as promising open sources to perform integrative…
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Performance of a multi-criteria algorithm based on urinalysis in predicting negative urine culture results
INTRODUCTION: Urinalysis by automated urine analyzer, including microscopy and dipstick test, is easy, rapid, and inexpensive. Among these parameters, leukocyte count (WBC) or leukocyte esterase (LE) has relatively sufficient sensitivity in urinary tract infection (UTI) detection. Urine culture is…
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Estimated glomerular filtration rate in identifying illness severity in newly admitted patients with COVID-19: A single-center study
INTRODUCTION: Early prediction of risk factors for serious illness and death in patients with coronavirus disease 2019 (COVID-19) appears to be a priority. This study aimed to examine whether a single estimated glomerular filtration rate (eGFR) at triage predicts the need for intensive care unit…
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Circulating sTWEAK and its scavenger receptor sCD163 concentrations in patients with Behçet's disease
INTRODUCTION: Behçet's disease (BD) is a chronic multisystemic inflammatory disorder and is associated with many inflammatory processes. The present study aimed to examine the serum levels of proinflammatory cytokine soluble tumor necrosis factor-like weak inducer of apoptosis (sTWEAK) and its…
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Estimation of measurement uncertainty of glycated hemoglobin at Atellica Solutions
INTRODUCTION: Glycated hemoglobin (HbA1c) is a commonly used laboratory test for screening, monitoring, and diagnosing diabetes mellitus (DM). Uncertainty is a statistical expression that shows the effects of factors arising during measurement processes and affecting the reported results. It is…
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Evaluation of total antioxidant capacity in human seminal plasma
INTRODUCTION: Male factor infertility accounts for up to half of all cases of infertility. Oxidative stress (OS) is a condition associated with an increased rate of cellular damage induced by oxygen and oxygen-derived oxidants, commonly known as reactive oxygen species (ROS). METHODS: Semen samples…
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Sigma metric evaluation with different TEa targets in clinical biochemistry
INTRODUCTION: The aim of this study was to evaluate the analytical performances of various clinical biochemistry analytes by the sigma metrics method according to different total allowable error (TEa) targets and to determine the causes of errors that lead to low sigma score by using Quality Goal…
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Tools for evaluating the performance of HbA1c analyzer: Sigma Metric and Quality Goal Index Ratio
INTRODUCTION: Sigma metric model is one of the most popular quality management system tools used for Six Sigma process improvement. This model provides three features that improve the results: low inaccuracy, less deviation, and correct performance of the analytical method. Internal quality control…
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Evaluation of babies with hyperphenylalaninemia diagnosed in the National Newborn Screening Program in Istanbul in 2019
INTRODUCTION: To evaluate the 2-year follow-up of hyperphenylalaninemia (HPA) patients born in 2019. METHODS: Growth, neuromotor development, and vitamin levels of 61 two-year-old babies followed up with the diagnosis of HPA in 2019 were evaluated. RESULTS: Thirty-six (59.02%) of the cases were…
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Total analytical error assessment of Yerköy State Hospital biochemistry laboratory
INTRODUCTION: In 2016, the maximum allowable CV% and allowable total error limits (TEa-TR) for 15 test parameters were specified by the Ministry of Health of Turkey and put into practice. Our study aimed to assess the analytical performance of 15 test parameters studied in our laboratory in terms…
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Ischemia modified albumin level and thiol/disulfide homeostasis in the etiology of tinnitus
INTRODUCTION: Although many theories about the etiology of tinnitus have been proposed, it has not been fully clarified. In this study, we investigated the role of ischemia in the etiology of tinnitus. METHODS: A total of 90 participants, 50 tinnitus patients and 40 controls, were included in this…
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Relationship between hematologic inflammatory indices and clinical findings in patients with acromegaly
INTRODUCTION: We primarily aimed to investigate the hematologic inflammatory parameters such as mean platelet volume (MPV), neutrophil-lymphocyte ratio (NLR), and platelet–lymphocyte ratio (PLR) in patients with acromegaly. We also aimed to reveal the importance of these parameters in determining…
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Artikel Jurnal
Thiol/disulfide homeostasis in gastritis with or without Helicobacter pylori
INTRODUCTION: In this study, it was aimed to evaluate how thiol/disulfide homeostasis is affected in Helicobacter pylori positive and negative gastritis and the efficiency of thiol/disulfide levels in the diagnosis of chronic gastritis. METHODS: Seventy patients with chronic gastritis (30 H. pylori…