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Biomedical and Biotechnology Research Journal
Scopus
ISSN 2588-9834 · Wolters Kluwer Medknow Publications · 662 articles in the index
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Journal Article
COG6 Novel Variant: From Prenatal Diagnosis to Successful Preimplantation Genetic Testing
COG6-congenital disorder of glycosylation type IIL (CDG2L) is a rare multisystemic autosomal recessive disorder caused by variants in the COG6 gene, a core component of the conserved oligomeric Golgi (COG) complex. To date, approximately 50 affected individuals with only 20 variants have been…
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Journal Article
Evaluation of Interleukin-8 and MicroRNA-155 Expression in Patients with Helicobacter pylori-Associated Gastritis
Background: Gastritis is among the most common gastrointestinal disorders worldwide and is associated with serious complications such as gastritis disease and gastric cancer. This study investigated the role of interleukin-8 (IL-8) and microRNA-155 (miRNA-155) expression in patients with…
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Journal Article
Stanniocalcin-2 Regulates Linear Growth via Growth Hormone/Insulin-like Growth Factor-1 Axis in Idiopathic Short Stature
Background: Idiopathic short stature (ISS) is characterized by a height below the mean for age, sex, and population, without identifiable systemic, endocrine, nutritional, or chromosomal abnormalities. Dysregulation of the growth hormone/insulin-like growth factor-1 (IGF-1) axis, particularly IGF-1…
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Journal Article
Nanosomal Docetaxel Promotes Ferroptosis-associated Biochemical Alteration in Michigan Cancer Foundation-7 Breast Cancer Cells
Background: Ferroptosis is an iron-dependent form of regulated cell death driven by lipid peroxidation and oxidative stress and emerging as a promising target for cancer therapy. Taxanes such as docetaxel (DTX) are widely used chemotherapeutics but require solvents such as polysorbate-80 and…
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Journal Article
In silico Design of a Novel Multi-epitope Chimeric Vaccine Targeting Mycobacterium tuberculosis Specific Antigens
Background: While the Bacillus Calmette–Guérin vaccine provides early-life protection, its waning efficacy in adults remains a critical barrier to global tuberculosis (TB) control. Despite several candidates targeting region of difference (RD) loci proteins entering clinical trials, a successful…
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Journal Article
Evaluation of Matrix-assisted Laser Desorption Ionization–Time of Flight Mass Spectrometry in Comparison with MPT64 Antigen Test and Multiplex Polymerase Chain Reaction for Mycobacterial Culture Identification
Background: Accurate and rapid identification of Mycobacterium species is essential for timely diagnosis and appropriate treatment of tuberculosis and nontuberculous mycobacterial (NTM) infections. Conventional methods are time-consuming and can have limited sensitivity, while Matrix-assisted Laser…
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Journal Article
Evaluation of Phytochemical and Antibacterial Activities of Ceylon Cinnamon and Salvia officinalis
Background: Antibacterial resistance is distributed worldwide, such as in the United States, killing about 23,000 patient/year. It occurs when bacteria evolve to evade the effect of antibiotics through neutralization of antibiotics, modifying their outer structure or receptor, or through mutation…
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Journal Article
Immunoinformatics of the Highly Conserved Region of Severe Acute Respiratory Syndrome Coronavirus 2 Spike Glycoprotein–Cholera Toxin B Subunit as a Vaccine Antigen and Its Interaction with Ganglioside GM1
Background: Before conducting challenge tests, cholera toxin B subunit (CTB) was incorporated into the highly conserved region (HCR) through a genetic fusion strategy. CTB will facilitate interaction between the HCR spike glycoprotein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)…
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Journal Article
In silico Characterization of Histidine Decarboxylase and SLIT and NTRK-like Family Member 1 Proteins in Tourette Syndrome: A Structural and Molecular Docking Approach
Background: Histidine decarboxylase (HDC) and SLIT and NTRK-like family member 1 (SLITRK1) are genes implicated in Tourette syndrome (TS) through roles in histaminergic neurotransmission, synaptic signaling, and neurodevelopment. This study aimed to characterize the structural and functional…
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Journal Article
Evaluating the Characteristics of Human Hair Follicle Dermal Papilla Cells in Aggregation Culture Procedure
Background: Human hair follicle dermal papilla cells (hHF-DPCs) play a critical role in hair follicle regeneration. Under conventional two-dimensional (2D) culture conditions, DPCs progressively lose the expression of key biological markers, suggesting that three-dimensional (3D) culture may better…
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Journal Article
In silico Guided Design of a Synthetic Peptide Vaccine Construct from Intrinsically Disordered Regions of the Group Specific Antigen Polyprotein
Background: The group specific antigen (Gag) polyprotein of human immunodeficiency virus-1 is an essential protein for the formation of virus particles and has emerged as a target for potential therapeutic interventions. Identification of viable linear B-Cell and cytotoxic T-Cell epitopes within…
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Journal Article
A Novel Functional Gradient and Multilayered Dysbiosis in Facial Seborrheic Dermatitis: New Insights from Shotgun Metagenomics
Background: Seborrheic dermatitis (SD) is a chronic inflammatory dermatosis affecting approximately 5% of the global population; however, diagnosis relies entirely on clinical assessment without objective laboratory confirmation. We evaluated shotgun metagenomics as a laboratory tool for…
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Journal Article
Biotechnological Optimization of Ultrasound-Assisted Extraction for Passion Fruit (Passiflora edulis) Peel Polysaccharides: Physicochemical Characterization and Their Potent Antioxidant and Antibacterial Activities
Background: Passion fruit peel (PFP) is an underutilized agricultural by-product rich in bioactive polysaccharides. This study aimed to optimize the ultrasound-assisted extraction (UAE) of polysaccharides from PFP (PFPPs) and evaluate their physicochemical, functional, and biological properties…
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Journal Article
Machine Learning-based Classification of Exercise Status Using miR-21 Expression and Multivariable Participant Profiles
Background: Circulating microRNAs (miRNAs) have emerged as promising molecular indicators of exercise-induced physiological adaptation. However, individual miRNAs have shown variable discriminatory performance across exercise contexts. miR-21 is of particular interest because of its proposed…
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Journal Article
Molecular and Immunological Characterization of Interleukin-40 and Interleukin-41 in Graves’ Disease Patients: An Iraqi Cohort Study
Background: Graves’ disease (GD) is an autoimmune thyroid disorder in which the roles of interleukin-40 (IL-40) and IL-41 remain poorly understood. We characterized the serological, transcriptional, and genetic profiles of these cytokines in an Iraqi GD cohort. Methods: In this exploratory…
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Journal Article
A Novel Variant in KCTD3 Gene in Patients with Global Developmental Delay, Seizures, and Cerebellar Hypoplasia
Pathogenic variants in KCTD3 are linked to severe neurodevelopmental disorders, but the clinical and genetic spectrum remains limited; reporting additional cases contributes to a better understanding of genotype–phenotype correlations. We report two affected siblings from a consanguineous Jordanian…
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Journal Article
In silico Identification of microRNAs Differentially Expressed in Prostate Cancer and Related to Tumor Aggressiveness
Background: Prostate cancer (PCa) remains a major clinical challenge due to the limited ability of current diagnostic tools to distinguish indolent from aggressive tumors. MicroRNAs (miRNAs) have emerged as promising biomarkers given their stability, tissue specificity, and regulatory roles in…
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Journal Article
m7G Modification and Immune Infiltration Profiles in Primary Sclerosing Cholangitis
Background: To explore the contribution of N7-methylguanosine (m7G) RNA modification to immune dysregulation in primary sclerosing cholangitis (PSC) and identify potential diagnostic biomarkers. Methods: Transcriptomic data (GSE177044) from peripheral blood mononuclear cells of 220 PSC patients and…
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Journal Article
Production of Phenolic and Antioxidant Compounds by Fungi through Solid-state Fermentation on Banana Peel
Background: Solid-state fermentation (SSF) has emerged as an effective bioprocess for converting agro-industrial residues into high-value bioactive compounds. In this study, the production of total phenolic compounds and antioxidant-related enzymes by Basidiomycete and Ascomycete fungi was…
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Journal Article
Inhibitory Effect of Essential Oil and Oleoresin of Clove (Syzygium aromaticum) on Food-Borne Escherichia coli and Salmonella spp.
Background: Foodborne pathogens, particularly Escherichia coli and Salmonella spp., present significant health risks, exacerbated by the growing resistance to antibiotics. This study explores the potential of clove (Syzygium aromaticum) essential oil and oleoresin as natural antimicrobial agents…