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iScience

Scopus

ISSN 2589-0042 · Elsevier · 13,163 articles in the index

  1. Journal Article

    Dissociating neural circuits of social and prosocial reward in rat helping behavior

    Keren Ruzal; Estherina Trachtenberg; Ben Kantor et al.

    iScience, Vol. 29 No. 2 · 2026 · English · DOAJ Scopus

    Summary: Helping behavior in rodents provides a powerful model for studying neurobiological underpinnings of prosocial motivation. Previously, rats allowed to release a trapped conspecific demonstrated prosocial motivation selectively toward ingroup members. Here, a refined version of the helping…

  2. Journal Article

    The Drosophila Him gene is essential for adult muscle function and muscle stem cell maintenance

    Robert Mitchell-Gee; Robert Hoff; Kumar Vishal et al.

    iScience, Vol. 29 No. 2 · 2026 · English · DOAJ Scopus

    Summary: Muscle stem cells (MuSCs), or “satellite cells,” are vital for vertebrate muscle growth, homeostasis, and repair. The discovery of analogous cells in Drosophila opens experimental opportunities in this genetically tractable model. Here, we show that the myogenic inhibitor gene Him, as well…

  3. Journal Article

    Self-assembly of plant-derived bioactive nanostructures in traditional Chinese medicine

    Hongzheng Zhu; Mingyuan Liu; Zemin Wang et al.

    iScience, Vol. 29 No. 2 · 2026 · English · DOAJ Scopus

    Summary: Traditional Chinese medicine (TCM) relies on plant-derived compounds to achieve therapeutic effects through multi-component and multi-level regulation. Increasing evidence indicates that many bioactive constituents in TCM can spontaneously self-assemble into nanoscale aggregates under…

  4. Journal Article

    What is next? Predictable visual sequences are encoded with anticipatory biases and reduced neural responses

    Songyun Bai; Maëlan Q. Menétrey; David Pascucci

    iScience, Vol. 29 No. 2 · 2026 · English · DOAJ Scopus

    Summary: Objects in motion follow predictable trajectories that the brain can easily anticipate. We investigated the underlying neural mechanisms, focusing on a form of representational momentum (RM), whereby the final state of a rotating object is misperceived along its future trajectory…

  5. Journal Article

    Large language models for predicting one-year major adverse cardiovascular events in acute coronary syndrome

    Xiaoming Zhang; Luxiang Shang; Siyu Hou et al.

    iScience, Vol. 29 No. 2 · 2026 · English · DOAJ Scopus

    Summary: Effective risk stratification is crucial for managing acute coronary syndrome (ACS). This study evaluated whether general-purpose large language models (LLMs) can reliably execute the complex clinical reasoning required for cardiovascular prognosis. We quantitatively assessed three…

  6. Journal Article

    Ancient gene linkages and ultraconserved elements disentangle Acari interrelationships

    Jyoti Prakash Bhoi; Rushikesh Mule; Nishaad Savale et al.

    iScience, Vol. 29 No. 2 · 2026 · English · DOAJ Scopus

    Summary: The interrelationships among Acari groups, Acariformes (mites) and Parasitiformes (ticks and parasitic mites) have been debated for long. We interrogated 90 genomes of Arachnida through a customized Chelicerata-wide ultraconserved elements bait set to resolve higher-level relationships of…

  7. Journal Article

    A new occurrence of saprotrophic oomycetes from the ca 307–303 million-years-old Grand’Croix Chert (Massif central, France)

    Christine Strullu-Derrien; Alan R.T. Spencer; Marc Gèze et al.

    iScience, Vol. 29 No. 2 · 2026 · English · DOAJ Scopus

    Summary: The Grand’Croix Chert (Massif Central, France) contains an exceptionally well-preserved plant assemblage, notable for its diverse reproductive structures. It also preserves numerous fungi and a few fungus-like microorganisms, of which only one has previously been formally described as an…

  8. Journal Article

    Hyperlipidemia exacerbates frozen shoulder fibrosis by activating the TGF-β/Smad2/3 signaling pathway via the TBX5-TNC-Itgα2 axis

    Fan Jiang; Yi Zhang; Jinlong Ma et al.

    iScience, Vol. 29 No. 2 · 2026 · English · DOAJ Scopus

    Summary: Hyperlipidemia is strongly implicated in frozen shoulder, but the molecular mechanisms linking this systemic metabolic disorder to localized joint fibrosis remain unknown. To elucidate this, we established a hyperlipidemic rat model and employed transcriptomics, along with comprehensive…

  9. Journal Article

    FAM65A, as a potential predictor of prognosis, promotes colorectal cancer progression via activating Ras/ERK/RSK signaling

    Yuqiu Ma; Jie Yao; Xinzhuang Shen et al.

    iScience, Vol. 29 No. 2 · 2026 · English · DOAJ Scopus

    Summary: Research indicates that FAM65A is significantly involved in tumorigenesis. Nevertheless, the prognostic implications of FAM65A expression levels and its contribution to CRC malignant progression have yet to be elucidated. Here, we revealed that FAM65A is overexpressed in CRC tissues and is…

  10. Journal Article

    Encoding of odor information and reward anticipation in anterior cortical amygdaloid nucleus

    Kazuki Shiotani; Yuta Tanisumi; Junya Hirokawa et al.

    iScience, Vol. 29 No. 2 · 2026 · English · DOAJ Scopus

    Summary: Olfactory information directly reaches the amygdala through the olfactory cortex, without the involvement of thalamic areas, unlike other sensory systems. The anterior cortical amygdaloid nucleus (ACo) is one of the olfactory cortices that receives olfactory sensory input and is part of…

  11. Journal Article

    Preparation of LaMn0.4Fe0.6O3/rGO composite catalyst for the thermolysis of ammonium perchlorate

    Taruna Likhariya; Pragnesh N. Dave

    iScience, Vol. 29 No. 2 · 2026 · English · DOAJ Scopus

    Summary: A LaMn0.4Fe0.6O3/rGO (6:1) perovskite composite was developed to enhance the thermal decomposition of ammonium perchlorate (AP). Optimization using DSC showed that the composite converts AP’s typical two-step decomposition into a single step and reduces the decomposition peak temperature…

  12. Journal Article

    Research progress in triboelectric nanogenerators based on new inorganic materials

    Meng-Nan Liu; Xu Li; Gang Zheng et al.

    iScience, Vol. 29 No. 2 · 2026 · English · DOAJ Scopus

    Summary: Based on contact electrification and electrostatic induction, triboelectric nanogenerators (TENGs) have emerged as a prominent technology for mechanical energy harvesting and conversion. Recent advances have been driven by new inorganic materials, including perovskites, graphene and its…

  13. Journal Article

    Thermophysical properties of 5-methylfurfural with alcohol additives: Toward efficient and sustainable biofuel blends

    Mohammad Almasi; Morteza Vatanparast

    iScience, Vol. 29 No. 2 · 2026 · English · DOAJ Scopus

    Summary: The transition toward sustainable energy systems requires renewable fuel alternatives with optimized combustion performance and reduced emissions. 5-Methylfurfural (MFF), a lignocellulosic biomass-derived furanic compound, has emerged as a promising biofuel precursor and blending. In this…

  14. Journal Article

    Denosumab ameliorates muscle indices in Chinese osteoporosis patients through clinical and bioinformatic evidence of RANKL in sarcopenia

    Shaotian Li; Shanshan Hu; Xiaoli Zheng et al.

    iScience, Vol. 29 No. 2 · 2026 · English · DOAJ Scopus

    Summary: This study investigated the effects of denosumab on muscle parameters in Chinese patients with primary osteoporosis and explored potential mechanisms through bioinformatic analyses. In a clinical trial involving 103 patients, 12 months of denosumab treatment significantly improved bone…

  15. Journal Article

    Risk of PM2.5 and its constituents for cardiovascular diseases: A cohort study of over 5.8 million participants

    Yutong Feng; Guoqing Fang; Juan Ouyang et al.

    iScience, Vol. 29 No. 2 · 2026 · English · DOAJ Scopus

    Summary: Fine particulate matter (PM2.5) exposure has been associated with increased cardiovascular disease (CVD) risk, but data from Northwest China are limited. We conducted a longitudinal cohort study with 5,838,833 participants enrolled between 2019 and 2021. Region-specific Cox models assessed…

  16. Journal Article

    Flexible self-cleaning temperature-pressure sensor based on rGO/TPU composite film

    Bin Zhang; Wenhong Sun

    iScience, Vol. 29 No. 2 · 2026 · English · DOAJ Scopus

    Summary: The integration of multi-functional and flexible wearable sensors is crucial for the development of comprehensive wearable electronic platforms. However, there is still much room for improvement in terms of response time and the accuracy of temperature detection. Here, a multifunctional…

  17. Journal Article

    Physical cognition in altered gravity: Link between sensorimotor and cognitive adaptability

    Minxin Cheng; Danyang Han; Maryam Haq et al.

    iScience, Vol. 29 No. 2 · 2026 · English · DOAJ Scopus

    Summary: A hallmark of human intelligence is rapid adaptation to changing environments. Yet the link between sensorimotor recalibration to new physical conditions and cognitive updating of internal models remains unclear. We addressed this using altered gravity as a model system. In a…

  18. Journal Article

    Multimorbidity and mortality trends in the COVID19 syndemic in Madagascar covering 180 diseases 2015 2024

    Modeste Kameni Nematchoua; Diana Ratsiambakaina; Faratiana Jenny Rasoariseheno et al.

    iScience, Vol. 29 No. 2 · 2026 · English · DOAJ Scopus

    Summary: Multimorbidity and mortality shape population health in Madagascar, where chronic and infectious diseases interact across regions. Using surveillance data covering 180 diseases across 22 regions from 2015 to 2024, we quantified geographic disparities, dominant contributors to disease…

  19. Journal Article

    Advancing reef recovery through insights into coral nutrition

    Jennifer L. Matthews; Christine Ferrier-Pagès; Jonathan Moorhead et al.

    iScience, Vol. 29 No. 2 · 2026 · English · DOAJ Scopus

    Summary: Coral reefs support immense biodiversity and human well-being, yet accelerating environmental change demands new strategies to strengthen reef resilience. Across ecological systems, balancing nutritional supply with organismal demand is fundamental to performance and persistence, but this…

  20. Journal Article

    Heritable ER stress impairs mitochondrial metabolism and maintenance of hematopoietic stem cells after low-dose irradiation

    Stephanie G. Moreno; Federica Ferri; Daniel Lewandowski et al.

    iScience, Vol. 29 No. 2 · 2026 · English · DOAJ Scopus

    Summary: How hematopoietic stem cells (HSCs) respond to low doses of radiation currently used in medicine is largely unknown. Here, we show that HSC exposed to a single 20 mGy dose of irradiation (20 mGy-HSC) exhibit, when proliferating, oxidative stress and altered metabolism associated with…

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