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Journal of the Egyptian National Cancer Institute
Scopus
ISSN 2589-0409 · SpringerOpen · 544 artikel di indeks
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Artikel Jurnal
Modulated calcium-sensing receptor (CaSR) expression in human breast cancer provided insights into tumor progression and therapeutic potential
Abstract The calcium-sensing receptor (CaSR) plays a crucial role in cellular signaling and has been implicated in cancer progression. However, its specific role in breast cancer remains unclear. This study aimed to investigate CaSR gene expression levels, its correlation with oncogenic pathways…
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Artikel Jurnal
Comprehensive Evaluation of Bacillus Calmette–Guérin therapy in Non-muscle invasive bladder cancer Egyptian patients: a retrospective cohort study
Abstract Background Bladder cancer ranks among the most prevalent genitourinary malignancies globally, demanding comprehensive management strategies. Bacille Calmette-Guerin (BCG) therapy, a standard for Non-Muscle Invasive Bladder Cancer (NMIBC), is integral to treatment, yet debates persist…
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Artikel Jurnal
Artificial intelligence-based machine learning models for preoperative diagnosis and staging of ovarian tumors
Abstract Background Ovarian cancer remains the most lethal gynecological malignancy, necessitating precise diagnostic strategies to improve patient outcomes. This study aims to develop and evaluate machine learning models that utilize patient history, imaging, and blood test data to differentiate…
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Artikel Jurnal
Significance of MALAT1 long non-coding RNA and miR-20a-5p in regulating epithelial mesenchymal transition in luminal breast cancer patients
Abstract Background Luminal breast cancer (LBC) is the most common subtype of breast cancer affecting women worldwide. Although luminal breast cancer typically has a better prognosis, it mostly responds poorly to neoadjuvant chemotherapy. Non-coding RNAs, especially long non-coding RNAs and…
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Artikel Jurnal
Positive rates of endometrial and cervical cytology in ovarian cancer patients with BRCA1/2 germline pathogenic variants
Abstract Background The optimal approach for early-stage ovarian cancer detection remains unclear, particularly in patients with hereditary breast and ovarian cancer (HBOC). As ovarian cancer in HBOC is often thought to originate from the fallopian tube fimbriae, endometrial cytology may play a…
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Artikel Jurnal
Male breast cancer in Arab populations: a systematic review of molecular, genetic, and clinicopathologic characteristics
Abstract Background Male breast cancer (MBC) accounts for less than 1% of all breast cancer cases, yet its incidence is increasing worldwide. Research on MBC remains limited, particularly in Arab populations, where molecular and genetic characteristics are poorly characterized. Improved…
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Artikel Jurnal
Recent advances in hormone-based biopharmaceuticals for cancer therapy
Abstract Hormone-dependent cancers, particularly estrogen receptor-positive breast cancer and androgen receptor-driven prostate cancer, contribute substantially to global cancer-related morbidity and mortality. Endocrine therapy has long been the mainstay of treatment for these tumors because of…
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Artikel Jurnal
Identification of potential biomarkers for oral squamous cell carcinoma through multi-cohort bioinformatic analysis
Abstract Background Oral squamous cell carcinoma (OSCC) arises in the context of diverse etiological exposures, such as tobacco, alcohol, areca nut use and viral infections. This etiological heterogeneity drives distinct molecular alterations, contributing to tumor complexity and significant…
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Artikel Jurnal
Epigallocatechin-3-Gallate, the green tea polyphenol suppresses expression of CD31 and VEGFR2 and enhances the chemotherapeutic potential of irinotecan in AOM/DSS model of colorectal cancer in mice
Abstract Background Conventional chemotherapeutic treatment of colorectal cancer causes adverse effects such as severe diarrhoea, mucositis and hepatotoxicity. This study aimed to investigate the anti-carcinogenic potential of epigallocatechin-3-gallate and its effects on major angiogenic markers…
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Artikel Jurnal
Comparative efficacy and safety of first, second, and third-generation EGFR tyrosine kinase inhibitors in treatment-naïve EGFR-mutant advanced non–small cell lung cancer: a systematic review and network meta-analysis of randomized controlled trials
Abstract Background The optimal first-line epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) for EGFR-mutant advanced non–small cell lung cancer (NSCLC) remains uncertain due to the availability of multiple generations of TKIs and limited head-to-head comparisons. Methods A…
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Artikel Jurnal
Tissue engineering driven regeneration in oral squamous cell carcinoma: from biomaterials to precision gene editing
Abstract Oral cancer is a significant global health challenge, ranking as the sixth most prevalent cancer worldwide, with approximately 377,000 new cases diagnosed annually. The high morbidity and mortality rates are largely attributed to tobacco and alcohol use. While conventional treatments such…
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Artikel Jurnal
Metformin enhances methylene blue-mediated photodynamic therapy in oral squamous cell carcinoma
Abstract Background Head and neck squamous cell carcinoma (HNSCC) is the most common malignancy of the head and neck region with relatively low survival rate and response and high resistance to treatment. Tongue and floor of the mouth are the most commonly involved sites. New therapies for oral…
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Artikel Jurnal
Metabolic and nutritional impact of gastrectomy and perioperative treatment in gastric cancer: a prospective cohort study
Abstract Background Gastrectomy due to gastric cancer leads to metabolic alterations in body composition, significantly affecting nutritional status. This prospective study aimed to investigate the metabolic effects of gastrectomy and perioperative treatment on the nutritional status of gastric…
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Artikel Jurnal
Microbiome and cancer immunotherapy: a bibliometric analysis
Abstract Objective To systematically analyze the global research landscape, collaboration patterns, knowledge flow pathways, and frontier trends in the synergistic effects between the microbiome and cancer immunotherapy. Methods A systematic bibliometric analysis of publications on the synergistic…
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Artikel Jurnal
The role of the microbiome in uterine cancer: insights into tumorigenesis, therapeutic implications, and clinical prospects
Abstract Malignant tumors of the uterine cavity are a leading cause of cancer-related mortality in women worldwide. In recent years, the tumor microenvironment, as a novel biological concept, has garnered increasing attention. The microenvironment plays a crucial role in the initiation…
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Artikel Jurnal
Radiosensitizing effect of astaxanthin on radiation–induced cytotoxicity in breast cancer cells
Abstract Background Radiotherapy (RT) is a primary treatment for cancer, including breast cancer, but its effectiveness is limited by severe side effects. Radiosensitization using natural products can enhance efficacy while reducing radiation doses. Astaxanthin (AST), a natural carotenoid with…
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Artikel Jurnal
Minimising pacemaker exposure in thoracic radiotherapy: a comparative study of IMRT, VMAT, and helical tomotherapy
Abstract Purpose Patients with cardiac implantable electronic devices (CIEDs) increasingly require thoracic radiotherapy, but comparative evidence guiding technique selection remains limited. This study evaluated CIED dose, target coverage, organ-at-risk (OAR) sparing, and delivery efficiency…
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Artikel Jurnal
In-vitro effects of the urotensin-II peptide and its receptor antagonists on mcf-7 breast cancer cell line
Abstract Background Urotensin-II is a powerful vasoconstrictor peptide. Both the peptide and its receptor, GPR14, affect central nervous system, cardiovascular system, and kidney functions. Urotensin-II was found to be involved in the development of many solid organ tumors. The peptide and its…
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Artikel Jurnal
Cholecystectomy-associated gut microbiota dysbiosis promotes colorectal carcinogenesis: from epidemiological controversy to FXR-centered mechanistic insights
Abstract Background and objective Cholecystectomy is one of the most common surgeries worldwide, yet its association with colorectal cancer (CRC) risk remains controversial. Recent advances have linked gut microbiota and bile acid alterations to this risk. This review synthesizes epidemiological…