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Digital Chinese Medicine
Scopus
ISSN 2589-3777 · KeAi Communications Co., Ltd. · 278 artikel di indeks
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Artikel Jurnal
Study on the dose-efficacy relationship of Dahuang (Rhei Radix et Rhizoma) based on fuzzy association rules
Objective: To investigate the dose-efficacy relationship of Dahuang (Rhei Radix et Rhizoma) using fuzzy association rules, provide scientific evidence for its precise clinical application, and establish a novel paradigm for research on the dose-efficacy relationship of Chinese materia medica (CMM)…
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Artikel Jurnal
Regulation of oocyte meiosis and reproductive function by Bushen Tiaojing Decoction through the APC/C-CDC20 signaling pathway in aged mice
Objective: To investigate the effects of Bushen Tiaojing Decoction (补肾调经汤, BSTJD) on oocyte meiotic progression and reproductive function in aged mice, and to explore the potential involvement of the anaphase-promoting complex/cyclosome (APC/C)-cell division cycle 20 (CDC20)-related signaling…
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Artikel Jurnal
Potential mechanisms of
Objective: To identify the potential molecular mechanisms mediating the role of Lycium barbarum polysaccharides (LBPs) in optic nerve regeneration (ONR) through an integrated approach that combines network pharmacology, single-cell RNA sequencing, and molecular docking. Methods: The monosaccharide…
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Artikel Jurnal
The molecular mechanisms of Liuwei Dihuang Decoction in improving cognitive dysfunction in D-galactose-induced aged mice revealed by an lncRNA‒miRNA‒mRNA network analysis
Objective: To elucidate the potential mechanisms by which Liuwei Dihuang Decoction (六味地黄汤, LWDHD) ameliorates D-galactose (D-gal)-induced cognitive impairment in aged mice through a long noncoding RNA (lncRNA)-micro RNA (miRNA)-messenger RNA (mRNA) regulatory network analysis. Methods: A total of…
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Artikel Jurnal
Effects of Liangxue Xiaofeng Powder on inflammatory responses and gut microbiota in atopic dermatitis rats with wind-dampness-heat syndrome
Objective: To investigate the potential therapeutic effects of Liangxue Xiaofeng Powder (凉血消风散, LXXFP) on atopic dermatitis (AD) rats with wind-dampness-heat syndrome, and to explore the potential mechanisms associated with inflammatory responses and gut microbiota alterations. Methods: Active…
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Artikel Jurnal
Protective effects of Bushen Huoxue Formula on intervertebral disc degeneration and endplate microcirculation in rats via the SIRT1/CXCL12/CXCR4/CXCR7 axis in endothelial progenitor cells
Objective: To investigate the efficacy of the Bushen Huoxue Formula (补肾活血方, BSHXF) in alleviating intervertebral disc degeneration (IVDD), improving endplate microcirculation, and enhancing endothelial progenitor cell (EPC) function, while investigating the potential role of the sirtuin 1…
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Artikel Jurnal
TCM-HyperRAG: higher-order knowledge hypergraphs for disease diagnosis and prescription recommendation in traditional Chinese medicine
Objective: To address the limitations of knowledge graphs in modeling higher-order associations in traditional Chinese medicine (TCM) knowledge and distinguishing the importance of different entities, we propose a weighted knowledge hypergraph-enhanced framework for intelligent assistance in TCM…
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Artikel Jurnal
Algorithmic consistency and feature-leakage assessment of machine learning models for traditional Chinese medicine syndrome differentiation in herpes zoster: a cross-sectional study
Objective: To evaluate whether standardized traditional Chinese medicine (TCM) syndrome labels in patients with herpes zoster can be reproduced from structured clinical variables and to determine how model performance changes after removing variables directly used to define the syndrome labels…
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Artikel Jurnal
Developing a diagnostic model for spleen-stomach damp-heat syndrome in chronic gastritis patients using hyperspectral tongue imaging
Objective: To construct a diagnostic model for spleen-stomach damp-heat syndrome in patients with chronic gastritis (CG) based on hyperspectral tongue imaging data, and to investigate the diagnostic value of hyperspectral tongue imaging in identifying spleen-stomach damp-heat syndrome in CG…
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Artikel Jurnal
A theory-constrained digital framework of the traditional Chinese medicine Jing-Shen-Mei theory for mammalian lifespan modeling
Objective: To construct a theory-constrained mathematical framework for the traditional Chinese medicine (TCM) Jing (精, essence)-Shen (神, spirit)-Mei (寐, sleep) theory and to evaluate the applicability of a pre-specified rational closure to cross-species mammalian lifespan prediction. Methods…
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Artikel Jurnal
Task-oriented compression of resampled pulse waves for lightweight blood pressure prediction
Objective: This study proposes a task-oriented signal compression paradigm for non-invasive blood pressure (BP) prediction, eliminating manual feature engineering through resampling to achieve a high-performance lightweight model suitable for embedded systems. Methods: The PDA-1 pulse diagnostic…
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Artikel Jurnal
Formalization, structural representation, and construction of equivalent mathematical expressions for basic theories of traditional Chinese medicine
Objective: To construct a formalized, structured, and equivalent mathematical representation framework for the basic theories of traditional Chinese medicine (TCM), and to illustrate the mathematical expression of the Bianzheng Lunzhi (辨证论治, syndrome differentiation and treatment) process using the…
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Artikel Jurnal
Attenuation of oxidative injury in retinal photoreceptor cells by Gouqizi (Lycii Fructus) and Danshen (Salviae Miltiorrhizae Radix et Rhizoma) through modulation of ANGPTL4
Objective: To investigate the protective effects of Gouqizi (Lycii Fructus, GQZ)-Danshen (Salviae Miltiorrhizae Radix et Rhizoma, DS) against hydrogen peroxide (H2O2)-induced oxidative injury in 661W retinal photoreceptor cells and to explore whether these effects involve angiopoietin-like 4…
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Artikel Jurnal
HerbGL: a network propagation and graph regularization-based framework for herb pairs prediction in traditional Chinese medicine
Objective: To address the challenges of systematically identifying herb pairs in traditional Chinese medicine (TCM), we proposed HerbGL, a framework for predicting potential herb pairs that integrates network propagation and graph regularization. Methods: Based on the assumption that herbal actions…
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Artikel Jurnal
Clinical efficacy and pharmacological basis of Mongolian medicine Manggari hot compress therapy for cervical spondylotic radiculopathy: a randomized controlled trial and serum pharmacochemistry study
Objective: To systematically evaluate the clinical efficacy of topical preparations of Mongolian medicine Manggari hot compress therapy (hereafter referred to as Manggari hot compress therapy) in treating cervical spondylotic radiculopathy (CSR) and explore the possible pharmacological material…
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Artikel Jurnal
CMM-EmbedCluster: a clustering framework for Chinese materia medica based on large language model and Chinese materia medica property theory
Objective: This study proposes a clustering framework for Chinese materia medica (CMM) based on a large language model (LLM), aiming to explore potential compatibility patterns among CMMs from the semantic perspective of CMM property theory. Methods: First, a CMM property knowledge base was…
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Artikel Jurnal
Comparative evaluation of Mamdani and Takagi-Sugeno fuzzy systems for predicting peripheral vascular resistance from photoplethysmogram signals using Persian medicine pulsology
Objective: To perform a comparative evaluation of Mamdani and Takagi-Sugeno (TS) fuzzy inference systems for predicting peripheral vascular resistance from photoplethysmogram (PPG) signals, incorporating diagnostic parameters from Persian medicine (PM) pulsology. Methods: Both fuzzy inference…
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Artikel Jurnal
Facial and tongue features in traditional Chinese medicine for coronary artery stenosis warning and their association chain with cardiac biomarkers
Objective: To explore whether digital facial and tongue diagnostic technologies can support the assessment of coronary heart disease (CHD) patients for coronary artery stenosis severity, and examine potential associations between digital tongue diagnosis features and myocardial biomarkers. Methods…
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Artikel Jurnal
Deep learning for subtype recognition of Yang deficiency tongue images in traditional Chinese medicine
Objective: To address the lack of fine-grained clinical recognition for specific Yang deficiency syndrome subtypes and the limitations of conventional object detection models in extracting irregular, low-contrast tongue phenotypes. This study aims to develop an objective subtype recognition…
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Artikel Jurnal
Molecular features of traditional Chinese medicine syndrome evolution in chronic liver diseases: a dynamic network biomarker analysis
Objective: To elucidate the biological basis of traditional Chinese medicine (TCM) syndromes from the perspective of “same syndrome, different diseases” in patients with chronic hepatitis B (CHB), liver cirrhosis (LC), and hepatocellular carcinoma (HCC), thereby providing a complementary approach…