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Journal of Translational Autoimmunity
Scopus
ISSN 2589-9090 · Elsevier · 334 articles in the index
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Journal Article
Antinuclear antibody targets in autoimmune hepatitis and drug-induced liver injury: Diagnostic relevance of nucleosome antibodies
Background & Aims: Anti-nuclear antibodies (ANA) are detected in 70–100 % of patients with autoimmune hepatitis (AIH) and in 22–33 % of patients with drug-induced liver injury (DILI). However, little is known about the specific antigens which they bind to. This study aimed to investigate the…
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Journal Article
A novel epigenetic regulation of JAM-A by EZH2-DNMT3A cascade contributes to T cell adhesion via the activation of Rap1a in lupus patients
Objectives: The peripheral blood T cells epigenetic modification and adhesion capacity alterations are the characteristic of SLE. EZH2 induces proinflammatory epigenetic changes in immune regulation. JAM-A widely involves in cell adhesion. However, the molecular regulation mechanisms between EZH2…
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Journal Article
Biopsy-proven myocarditis: peripheral immunophenotypes correlate with histology, etiology, immunosuppressive therapy
Background: Myocarditis is an inflammatory disease of the myocardium with infectious or immune-mediated/autoimmune etiology; etiology diagnosis relays on endomyocardial biopsy (EMB). High titre serum anti-heart autoantibodies (AHA) define severe autoimmune forms. In autoimmune myocarditis…
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Journal Article
Type I interferon-dependent and -independent signaling underlie autoantibody production in a murine lupus model
Systemic lupus erythematosus (SLE) is characterized by the development of autoantibodies against diverse self-antigens and damage to multiple organs. Immunization with the SLE autoantigen β2-glycoprotein I and lipopolysaccharide (LPS) induces a murine model of SLE with the sequential emergence of…
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Journal Article
Long-term natural history of thyroid peroxidase antibodies in a population-based cohort: Findings from 18 years of follow-up in Tehran Thyroid Study (TTS)
Background: Thyroid peroxidase antibody (TPOAb) is considered a highly sensitive marker of autoimmune thyroid diseases (AITD). Limited longitudinal data exist regarding its long-term natural history in the general population. This study aimed to assess risk factors for TPOAb positivity and its…
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Journal Article
Age-dependent association of thyroid peroxidase antibodies with incident cardiovascular disease events: Insights from a longitudinal cohort study
Background: The relationship between thyroid autoimmunity and cardiovascular disease (CVD) is controversial, and age-specific effects are not well characterized. We examined associations between thyroid peroxidase antibodies (TPOAb) status and incident CVD. Methods: In this prospective…
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Journal Article
Rituximab remodels the circulating immune landscape in pemphigus vulgaris revealed by high-dimensional immune profiling
Pemphigus vulgaris (PV) is a severe autoimmune blistering disease characterized by pathogenic autoantibodies primarily targeting desmoglein-3. B-cell depletion by rituximab (anti-CD20) is an effective first-line treatment for PV; however, relapses are frequently observed. Evidence suggests that PV…
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Journal Article
Immune dysregulation in osteoarthritis: Mechanisms, biomarkers, and therapeutic opportunities
Osteoarthritis (OA) is increasingly recognized as a heterogeneous, immune-modulated joint disease in which chronic low-grade synovial inflammation contributes to structural degeneration and pain, challenging its historical classification as a purely mechanical disorder. Central to this paradigm…
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Journal Article
Persistent cutaneous lupus erythematosus: A pathway toward systemic disease?
Cutaneous lupus erythematosus (CLE) is an inflammatory autoimmune disease characterized by specific skin lesions, differing from systemic lupus erythematosus (SLE) which affects multiple organs widely. Although CLE has traditionally been regarded as a cutaneous-limited disorder, increasing evidence…
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Journal Article
“CANDLE syndrome: A closer look at a rare autoinflammatory disorder”
A newly identified autoinflammatory condition called CANDLE syndrome (chronic atypical neutrophilic dermatosis with lipodystrophy and increased temperature) is characterized by early onset, recurring fever, skin lesions, and multisystemic inflammatory symptoms. It has been demonstrated that the…
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Journal Article
Downregulated ECHS1 and HADH-mediated fatty acid β-oxidation contributes to mitochondrial dysfunction in salivary glands of Sjögren's syndrome
Background: Sjögren's syndrome (SS) is a common autoimmune disease characterized clinically by dry mouth and dry eyes resulting from impaired exocrine gland function. However, its precise pathogenesis remains incompletely understood. Mitochondria, as cellular energy hubs, maintain homeostasis via…
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Journal Article
Liraglutide prevents lupus-associated diffuse alveolar hemorrhage via inhibiting lymphocyte infiltration and promoting macrophage M2 polarization
Objectives: This study aimed to explore the prophylactic and therapeutic role of liraglutide for lupus-associated diffuse alveolar hemorrhage (DAH). Methods: A lupus-associated DAH model was established in 6-8-week-old female C57BL/6 mice via intraperitoneal injection of 0.5 mL pristane. Mice were…
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Journal Article
Immunoprotective and neuroprotective properties of gut microbiome in psoriasis
Psoriasis impacts nearly 100 million people globally and is associated with neuropsychiatric comorbidities such as depression and anxiety. With gut microbiome dysbiosis serving as a primary pathophysiological factor, the gut-brain-skin axis provides a crucial framework for understanding this…
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Journal Article
Epigenetic advances in rheumatic heart disease
Rheumatic heart disease (RHD), an autoimmune injury triggered by group A streptococcus (GAS) infection, exerts a significant pathological impact on the human heart. The pathogenesis of RHD is closely associated with abnormal epigenetic regulation, and primarily involves the four core epigenetic…
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Journal Article
Emerging cell-based and cell-free therapeutic strategies for vitiligo
Vitiligo is a chronic, acquired skin disorder characterized by the loss of pigmentation due to the destruction or dysfunction of melanocytes. Conventional treatments such as corticosteroids and phototherapy often produce limited and unpredictable outcomes. In recent years, novel therapeutic…
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Journal Article
Mendelian randomization study of the causal relationship between autoimmune diseases and anemia using proteomic and genetic data
Background: Observational studies have suggested a potential association between autoimmune diseases and anemia, but the direction of causality remains unclear. To investigate the potential causal relationship between autoimmune diseases and anemia using Mendelian randomization (MR). Methods: We…
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Journal Article
Discovery of a PDE4B and PDE4D selective bifunctional degrader for management of chronic inflammatory disorders
Atopic dermatitis (AD) is a chronic inflammatory skin disorder characterized by redness and itching, impacting over 15 million individuals in the US. The pathogenesis of AD involves T helper 2 (TH2) and 17 (TH17) cytokines, which contribute to increased inflammation, a compromised skin barrier, and…
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Journal Article
Rheumatoid factor and anti-citrullinated protein IgA antibodies in the diagnosis, prognosis and monitoring of patients with rheumatoid arthritis
Over the past decades immunoglobulin A (IgA) antibodies have gained increasing attention for their diagnostic and prognostic significance in rheumatoid arthritis (RA), complementing the well-established roles of IgM rheumatoid factor (RF) and IgG anti-citrullinated protein antibodies (ACPA). IgA-RF…
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Journal Article
Epidemiological assessment of six major immune-mediated inflammatory diseases based on the Global Burden of Disease Study 2021: analyses of age-standardized incidence, prevalence, mortality, and disability-adjusted life years
Objective: Immune-mediated inflammatory diseases (IMIDs) are a group of chronic conditions characterized by dysregulated immune responses and tissue inflammation, posing a significant challenge to global health. However, comprehensive epidemiological analysis of the burden of these diseases remains…