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Metabolism Open
ISSN 2589-9368 · Elsevier · 464 artikel di indeks
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Artikel Jurnal
Metabolic syndrome score and cardiovascular disease risk in adults with cardiovascular-kidney-metabolic syndrome stages 0–3: A prospective cohort study
Background: The American Heart Association (AHA) introduced the Cardiovascular-Kidney-Metabolic (CKM) syndrome framework, emphasizing the interplay of metabolic risk factors, chronic kidney disease, and cardiovascular disease (CVD). Whether the metabolic syndrome (MetS) score—a simple count of…
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Real-world treatment-transition pathways and dosing patterns of insulin degludec/liraglutide in Chinese adults with type 2 diabetes
Background and aims: To describe real-world treatment-transition pathways, early IDegLira dosing patterns, treatment simplification, and observed short-term clinical outcomes among Chinese adults with type 2 diabetes (T2D). Methods: This multicenter, non-interventional, retrospective observational…
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Curcumin modulates the adipose FBN1–Asprosin axis and improves metabolic dysfunction in a rat model of type 2 diabetes
Background: Asprosin, a glucogenic adipokine derived from the C-terminal region of profibrillin-1 encoded by FBN1 , has emerged as a potential regulator of glucose homeostasis and insulin resistance. However, the effects of curcumin on the adipose FBN1–asprosin axis in type 2 diabetes mellitus…
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Artikel Jurnal
Ensemble learning uncovers novel metabolomic biomarkers for early osteoporosis prediction in Tibetan plateau populations
Background: Osteoporosis represents a prevalent metabolic bone disorder among middle-aged and elderly populations, with its prevention and early detection holding important implications for clinical practice and public health. While extensive research has characterized osteoporosis in low-altitude…
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Artikel Jurnal
What's in a name? From PCOS to polyendocrine metabolic ovarian syndrome: A metabolic reframing, promise, controversies, and challenges ahead
In medicine, nomenclature shapes diagnostic reasoning, clinical pathways, research priorities, and patients' understanding of their condition. Polycystic ovary syndrome (PCOS), the most common endocrine disorder in women of reproductive age, affecting one in eight women and more than 170 million…
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Early ICU glycemic trajectory phenotypes predict short- and long-term mortality in critically ill patients: a dual-database cohort study
Aims: Dysglycemia is common in critically ill patients and is associated with adverse outcomes, but the prognostic significance of early ICU glycemic patterns remains unclear. Methods: In this dual-database cohort study, 60,365 critically ill patients from MIMIC-IV were used for model development…
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Effects of resistance, endurance, and combined exercise training on body composition, glycemic control, and serum albumin in women with type 2 diabetes: A randomized controlled study
Objectives: The aim of the present study was to investigate serum albumin (ALB) levels in patients with type 2 diabetes following different exercise protocols and to examine its association with body composition as a factor related to muscle atrophy. Methods: In this pre-test/post-test clinical…
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Artikel Jurnal
Efficacy and safety of novel formulation of semaglutide injection: A multicentre, randomized, comparative, active controlled, phase 3 study in comparison with reference biologic in Indian patients with type 2 diabetes mellitus
Background: Type 2 diabetes mellitus (T2DM) is the most common non-communicable disease affecting over 89.8 million adults in India. Evidence suggests long-acting glucagon-like peptide-1 (GLP-1) receptor agonist improves glycaemic control in the patients with T2DM. This phase 3 trial compared a…
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Uric Acid–to–HDL cholesterol ratio and probable MASLD across adiposity strata in postmenopausal women
Purpose: To examine the association between serum uric acid–to–HDL cholesterol ratio (UHR) and probable metabolic dysfunction–associated steatotic liver disease (MASLD) in postmenopausal women, and to assess whether this association varies across body mass index (BMI) strata. Methods: This…
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Artikel Jurnal
Metabolic dysfunction and insulin resistance across major dementias: A comprehensive narrative review of the TyG index as a predictive marker
Dementia is a progressive neurodegenerative disorder and a leading cause of disability worldwide, with Alzheimer's disease (AD), vascular dementia (VaD), and Lewy body dementias (LBD) representing the most common subtypes. Its rising prevalence, driven by population aging, underscores the urgent…
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Artikel Jurnal
Central nervous system adaptation mechanism of obesity induced by high-fat high-sucrose diet: Differences in brain function between obese and obese resistant rats based on fMRI
Objective: The prevalence of metabolic obesity continues to rise, yet its pathogenesis remains controversial. This study focuses on the central neural regulatory differences underlying phenotypic divergence between diet-induced obese (OB) and obesity-resistant (OR) rats following long-term high-fat…
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Bioactive fractions of Solanum aethiopicum leaves improve glucose homeostasis, lipid metabolism and oxidative stress in experimental type 2 diabetes
Background and aim: one of the direct consequences of obesity is insulin resistance, which can lead to type 2 diabetes. Numerous treatments for this form of diabetes have been developed, but given the high cost of these drugs and their many side effects, more and more patients are turning to…
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Artikel Jurnal
Long-term postdischarge immunonutrition management in elective colorectal cancer surgery patients an interim analysis of a Chinese multicenter randomised controlled trial
Postoperative malnutrition is prevalent in cancer patients, and enteral nutrition improves short-term outcomes. However, long-term data on post-discharge immunonutrition (IMN) effects on nutritional and immune status in colorectal cancer (CRC) patients after radical surgery are limited…
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Association of the Dietary Index for Gut Microbiota with site-specific Osteoporosis: Insights from machine learning applied to a national population
Background: The association between the Dietary Index for Gut Microbiota (DI-GM) and site-specific osteoporosis risk remains unclear. Methods: This study analyzed data from five NHANES cycles (2005–2010, 2013–2014, 2017–2018). Multivariate logistic regression and subgroup analyses were conducted to…
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Artikel Jurnal
Influence of metabolic syndrome on infertility: A review
Background: Metabolic Syndrome (MetS) is a cluster of metabolic abnormalities including abdominal obesity, impaired glucose metabolism, hypertriglyceridemia, low high-density lipoprotein (HDL) cholesterol, and hypertension. It is diagnosed when at least three of these five criteria are present…
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Bridging exercise biology and immunometabolism: A novel irisin pathway toward next-generation metabolic and neurodegenerative therapies
Recent work by Mu et al. identifying irisin as a modulator of adipose tissue IL-33 and regulatory T cells introduces a new paradigm in immunometabolic biology, shifting attention from thermogenesis alone toward immune–stromal crosstalk as a determinant of metabolic health. By inducing IL-33…
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Comparative effects of regular, bloomed or white chocolate on cardiovascular and antioxidant markers in healthy adults
Background: Cardiovascular diseases (CVDs) remain the leading cause of mortality worldwide, highlighting the need for effective dietary strategies to mitigate risk. Cocoa-rich dark chocolate contains bioactive compounds with reported cardioprotective effects; however, evidence regarding the impact…
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Artikel Jurnal
Obesity pharmacotherapy reimagined: The era of multi-receptor agonists and next-generation metabolic modulators, perspectives and controversies
Obesity affects over 2 billion adults globally, with projections indicating that nearly two-thirds of adults will be affected by 2050. Glucagon-like peptide-1 receptor agonists (GLP-1RAs) have transformed obesity treatment, achieving weight loss previously considered attainable only with bariatric…