172 results

Basilar artery thrombosis secondary to vertebral artery dissection in a patient with hypoplastic vertebral artery terminating in posterior inferior cerebellar artery: A case illustrating the clinical impact of vertebrobasilar anatomical variants

Qusai Bashir AI-Khair Odeh; Heng Wang; Shule Wang

Vascular Investigation and Therapy, Vol. 9 No. 2 · 2026 · English · DOAJ

Vertebral artery dissection (VAD) stands as a prominent etiology of posterior circulation ischemic stroke, especially among young adults, manifesting clinically across a spectrum from subtle signs to devastating brainstem and cerebellar infarctions. The clinical labyrinth of VAD deepens when…

A novel model of murine chronic limb ischemia using partial femoral artery ligation

Honglin Dong; Luyu Yao; Shyamal Premaratne et al.

Vascular Investigation and Therapy, Vol. 9 No. 2 · 2026 · English · DOAJ

OBJECTIVES: Current hind limb peripheral artery disease (PAD) animal models, which claim to mimic chronic limb ischemia, are examples of acute limb ischemia because of total ligation of the femoral artery. In this study, we have created a novel animal model using partial femoral artery occlusion to…

Adenomyosis and venous thromboembolism: High-risk factors and clinical management strategies

ChangJie Sun; Xiaoqin Li; Di Wu et al.

Vascular Investigation and Therapy, Vol. 9 No. 2 · 2026 · English · DOAJ

Adenomyosis (AM), a common benign gynecological disorder in reproductive-aged women, is characterized by menorrhagia, dysmenorrhea, and infertility. Epidemiological studies indicate that approximately 12.2% of AM patients exhibit an elevated risk for venous thromboembolism (VTE). Although the…

Advances in the endovascular management of lower extremity arterial calcification

Wenfeng Lin; Fandi Mo; Lexin Wang et al.

Vascular Investigation and Therapy, Vol. 9 No. 2 · 2026 · English · DOAJ

Lower extremity arterial calcification remains a major challenge in vascular surgery. Its treatment has evolved from conventional balloon angioplasty and stent implantation into an era of individualized therapy centered on calcium debulking technologies, including atherectomy and intravascular…

Trends of venous thromboembolism mortality rate among US adults, 1999–2024

Qian Wang; Meng Li; Rui Feng et al.

Vascular Investigation and Therapy, Vol. 9 No. 2 · 2026 · English · DOAJ

BACKGROUND: Venous thromboembolism (VTE), including deep vein thrombosis (DVT) and pulmonary embolism, is a major cause of cardiovascular morbidity and mortality in the United States. This study examined long-term trends in VTE-related mortality from 1999 to 2024, with a focus on demographic and…

Winter is coming: Cold exposure, temperature variability, and the fragility of the aorta

Keyi Fan; Jiang Han; Manhong Yi et al.

Vascular Investigation and Therapy, Vol. 9 No. 2 · 2026 · English · DOAJ

Congenital absence of the inferior vena cava: Azygos vein filter placement and retrieval for pulmonary embolism

Yuchen Zhu; Peng Zhou; Qin Li

Vascular Investigation and Therapy, Vol. 9 No. 1 · 2026 · English · DOAJ

The azygos vein serves as an important channel connecting the superior and inferior vena cava (IVC). When venous return through the IVC is obstructed, this pathway becomes a crucial collateral circulation route. This article reports a case of a 39-year-old woman with complete absence of the IVC…

Research progress in preoperative simulation of endovascular aneurysm repair for abdominal aortic aneurysm

Xinghua Liu; Zhi Li; Qingsheng Lu

Vascular Investigation and Therapy, Vol. 9 No. 1 · 2026 · English · DOAJ

This review synthesizes advances in preoperative simulation for endovascular aneurysm repair (EVAR) of abdominal aortic aneurysms (AAA). While EVAR is the first-line therapy, its success is critically dependent on precise planning. Conventional 2D imaging often fails to address complex anatomical…

Nationwide spatiotemporal patterns of aortic aneurysm mortality and temperature-related risk in the United States (1999–2023)

Heng Wang; Keyi Fan; Guoping Zheng

Vascular Investigation and Therapy, Vol. 9 No. 1 · 2026 · English · DOAJ

BACKGROUND: Although aortic aneurysm (AA) mortality has declined in recent decades, contemporary nationwide evidence in the United States and the potential impact of ambient temperature on AA mortality remain limited. METHODS: We analyzed AA mortality among individuals aged ≥25 years in the United…

Thoracic hyperextension maneuver expands transcarotid artery revascularization eligibility

Julia Fayanne Chen; Ilias P. Doulamis; Naiem Nassiri

Vascular Investigation and Therapy, Vol. 9 No. 1 · 2026 · English · DOAJ

PURPOSE: The purpose of this study was to evaluate the effect of a thoracic hyperextension (THE) positioning maneuver on clavicle-to-carotid bifurcation (CCB) distance in patients undergoing transcarotid artery revascularization (TCAR) and to determine whether this technique may expand anatomic…

Individualized interventional treatment and follow-up in a patient with duplication of the inferior vena cava, advanced breast cancer, and acute high-risk pulmonary embolism

Jianshan Shi; Tang Deng; Minglin Zhang et al.

Vascular Investigation and Therapy, Vol. 9 No. 1 · 2026 · English · DOAJ

Duplication of the inferior vena cava (DIVC) is a rare congenital anomaly that complicates diagnosis and treatment, especially in patients with deep-vein thrombosis (DVT). We report the complex case of a 64-year-old woman with advanced breast cancer, acute right lower extremity DVT, high-risk…

Comparative analysis of scoring balloons versus high-pressure balloons in the treatment of autologous arteriovenous fistula dysfunction

Yanjun Luo; Ni Zhao; Lin Huang et al.

Vascular Investigation and Therapy, Vol. 9 No. 1 · 2026 · English · DOAJ

OBJECTIVE: The objective of this study was to evaluate the efficacy and safety of scoring balloons (SBs) versus high-pressure balloons (HPBs) in the treatment of autologous arteriovenous fistula dysfunction (AAFD) and to provide evidence for balloon catheter selection in clinical practice…

The chronically swollen leg with ulcers – Finding the cause: Theory and practice

Pier Luigi Antignani; Luca Costanzo; Giacomo Failla et al.

Vascular Investigation and Therapy, Vol. 9 No. 1 · 2026 · English · DOAJ

Type IIIb endoleak associated with stent graft fracture following endovascular repair of a proximal descending thoracic aortic aneurysm

Seock Yeol Lee

Vascular Investigation and Therapy, Vol. 8 No. 3 · 2025 · English · DOAJ

Thoracic aortic aneurysms are increasingly treated with thoracic endovascular aortic repair (TEVAR) because it is less invasive than open surgery. However, postprocedural complications such as endoleaks may occur, with Type IIIb endoleaks – those involving graft fabric disruption such as fabric…

PANoptosis: A new perspective on the pathogenesis of cardiovascular diseases

Peng Long; Liyun Zhang; Xinan Qiao et al.

Vascular Investigation and Therapy, Vol. 8 No. 3 · 2025 · English · DOAJ

PANoptosis, a newly identified programmed cell death pathway, clarifies the complex cross-talk among pyroptosis, apoptosis, and necroptosis. Its initiation involves the assembly and activation of PANoptosomes, which, despite varying in composition, converge on key molecules in pyroptosis…

Contemporary advances in aortic disease: From treatment innovation to artificial intelligence integration

Manuel Quiroz Flores; Chawannuch Ruaengsri; Marc Leon

Vascular Investigation and Therapy, Vol. 8 No. 3 · 2025 · English · DOAJ

Aortic disease remains a major contributor to cardiovascular morbidity and mortality worldwide. Advances in the understanding of its epidemiology, pathophysiology, and anatomical classification have strengthened the clinical foundation for risk assessment and therapeutic decision-making. The…

A brief glimpse at cuproptosis in aortic aneurysm and the therapeutic prospects

Xue Dong; Lin Xia; Yuting Huang et al.

Vascular Investigation and Therapy, Vol. 8 No. 3 · 2025 · English · DOAJ

Cuproptosis is a newly identified form of regulated cell death triggered by copper-induced mitochondrial stress. Recent studies suggest that it plays a key role in maintaining vascular homeostasis and contributes to the development of aortic aneurysm (AA). This review summarizes current findings…

Validation of a health economics evaluation framework for minimally invasive congenital heart disease clinical pathways: A multi-center disparity analysis

Xiang Li; Chao Xue; Kai Ren et al.

Vascular Investigation and Therapy, Vol. 8 No. 3 · 2025 · English · DOAJ

BACKGROUND: Significant regional disparities exist in implementing minimally invasive congenital heart disease (CHD) clinical pathways across China, leading to inefficient resource utilization and increased healthcare costs. METHODS: Using the Sino-CHD registry (n = 7001 patients from 13 centers)…

Correlation and predictive factors of carotid artery stenosis and stroke after transcatheter aortic valve replacement: A multicenter retrospective study

Yu Mao; Hongmei Lai; Yujing Zhang et al.

Vascular Investigation and Therapy, Vol. 8 No. 3 · 2025 · English · DOAJ

BACKGROUND: Stroke is one of the severe complications following transcatheter aortic valve replacement (TAVR). However, the association between carotid artery stenosis (CAS) and post-TAVR stroke remains unclear. METHODS: Patients who received TAVR consecutively between July 2023 and December 2024…

Erratum: Nine-year follow-up of patients receiving recombinant human hepatocyte growth factor nude plasmid DNA for critical limb ischemia: Updated safety and efficacy results

Vascular Investigation and Therapy, Vol. 8 No. 4 · 2025 · English · DOAJ