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Materials Today Bio
Scopus
ISSN 2590-0064 · Elsevier · 2,563 articles in the index
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Journal Article
Harnessing polysaccharide-mediated biomineralization for advanced bone tissue engineering
Biomineralization is a critical process wherein organisms form mineral composites via organic-inorganic synergistic interactions, which are essential for maintaining and repairing bone tissue homeostasis. Polysaccharides, as a class of natural biological macromolecules, play a crucial role in…
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Journal Article
Unveiling aucubin-mediated inhibition of PANoptosis in lower limb ischemia-reperfusion injury with a near-infrared H2O2 fluorogenic probe
Although reactive oxygen species (ROS)-mediated PANoptosis plays a pivotal role in the pathological dysfunction of lower limb ischemia/reperfusion injury (LL-IRI), its exact mechanism remains unclear. Real-time detection of H2O2 will help to reveal the complicated relationship between ROS…
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Journal Article
Nanozyme for precision treatment of hepatocellular carcinoma
Hepatocellular carcinoma (HCC) remains a formidable challenge due to profound heterogeneity, recurrence, and pervasive therapeutic resistance, creating a significant unmet clinical need. Engineered nanozymes, nanomaterials with intrinsic catalytic activities, have emerged as a transformative…
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Journal Article
Engineered targeted Ce-based MOF nanozymes for ROS scavenging and inflammatory Reprogramming in chronic pancreatitis
Chronic pancreatitis (CP) is a lifelong progressive fibrotic inflammatory disorder for which no effective cure is currently available. Persistent and recurrent inflammatory stimulation induced by reactive oxygen species (ROS) is a key driver of pancreatic fibrogenesis, making oxidative stress a…
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Journal Article
Graphene oxide coating on two-dimensional glass substrates and three-dimensional zirconia scaffolds for bone tissue regeneration
Zirconia (ZrO2) scaffolds are considered promising candidates for bone regeneration owing to their excellent biocompatibility and mechanical strength. However, intrinsic bioinertness and the formation of microcracks during sintering remain major challenges that limit their clinical translation…
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Journal Article
A synergistic strategy of AIE and electron asymmetry anchored in covalent organic frameworks for enhanced periodontitis photodynamic therapy
Periodontitis, a widespread inflammatory disease, is difficult to treat effectively due to incomplete mechanical cleaning and increasing antibiotic resistance. To overcome this issue, we developed a new covalent organic framework, THP-PE-COF, which combines aggregation-induced emission (AIE) with…
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Journal Article
MnOx-armored magnesium implants for anti-osteosarcoma and biofilm eradication by charge-transfer interference
Frequent tumor recurrence and postoperative bacterial infections after osteosarcoma surgery have increased the demand for advanced bone implants. Although magnesium and its alloys are considered promising candidates for next-generation bone implants, their clinical application remains limited due…
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Journal Article
A purpurin-based metalloimmunostimulant amplifies ROS and modulates STING/TNF-α axis to potentiate melanoma immunotherapy
The low infiltration of pro-inflammatory immune cells and the sustained activation of multiple immunosuppressive signaling pathways in melanoma significantly limit the efficacy of clinical immunotherapy. Therefore, developing an effective immunostimulant with reversing the immunosuppressive tumor…
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Journal Article
A multifunctional mitochondria-targeted nanoparticle for the effective treatment of dry eye disease via reactive oxygen species scavenging
Dry eye disease is a prevalent ocular surface disorder primarily driven by oxidative stress and inflammation, remains a therapeutic challenge due to the limitations of current treatments. In this study, we developed a multifunctional nanoparticle system, using a layer-by-layer self-assembly…
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Journal Article
Ultrasound-responsive hydrogel with ROS scavenging and NO controllable release capabilities for accelerated healing of diabetic wounds
Diabetic wounds represent a common and challenging complication of diabetes mellitus, characterized by a complex pathological microenvironment that includes excessive reactive oxygen species (ROS), chronic inflammation, hypoxia, and impaired nitric oxide (NO) synthesis. These factors collectively…
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Journal Article
Alendronic acid modified PLGA drug delivery system loaded with 17β-Estradiol and vitamin D3 has anti-osteoporotic effect
Postmenopausal osteoporosis caused by estrogen deficiency often requires hormone replacement therapy (HRT), but its systemic side effects limit clinical application. Here, we developed a bone-targeted Poly (lactic-co-glycolic acid) (PLGA) nanocarrier modified with Alendronic acid (ADA) to…
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Journal Article
pH-responsive ZIF-8@quercetin nanoparticles induce pyroptosis for targeted gastric cancer therapy
Gastric cancer (GC) remains a major global health burden, with limited effective therapies and poor prognosis. Quercetin (Que), a natural flavonoid, exhibits anticancer activity but suffers from poor water solubility, limited oral bioavailability, and rapid metabolic clearance, which severely…
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Journal Article
Nanomaterial-enabled rheumatoid arthritis treatment: An advanced investigation into photonic - acoustic - gaseous multimodal therapy
Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease. Current treatments mainly involve drugs and surgery, but face limitations like adverse effects, invasive complications, and poor outcomes. Emerging nanomaterial-mediated modalities, particularly photothermal therapy (PTT)…
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Journal Article
Dual-responsive PDA-HP hydrogel enables mitochondria-targeted mild photothermal therapy for spinal cord repair
Spinal cord injury (SCI) is a devastating neurological disorder with substantial economic and psychological burdens, underscoring the urgent need for effective therapeutic strategies. Here, we developed a dual-responsive hydrogel composed of polydopamine (PDA) and heparin-poloxamer (HP) that…
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Journal Article
Minimal immune response after transplantation of a cryopreserved human amniotic membrane on the ocular surface
Introduction: Human amniotic membrane (hAM) is considered to have low immunogenicity since Akle et al. reported no anti-HLA antibodies (Abs) in four volunteers after subcutaneous grafting of fresh hAM in 1981. But the sensitivity of the detection methods has significantly improved since then…
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Journal Article
Ganoderma lucidum polysaccharide-decorated extracellular vesicle enables synergistical antitumor immunotherapy
Ganoderma lucidum polysaccharide (GLP) holds considerable promise for tumor therapy, but its clinical application is limited by its poor tumor-targeting capability. Herein, we report the development of an immunoregulatory nano-bioconjugate formed by conjugating GLPs with low-pH culture medium…
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Journal Article
Bioprinting and assembly of organ building blocks for tissue engineering applications
Damage or functional failure of vital organs remains a major clinical challenge, while the availability of donor organs for transplantation is severely limited. As a result, tissue engineering has emerged as a promising strategy for organ replacement; however, conventional top-down tissue…
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Journal Article
3D bioprinted composite scaffold incorporating microfluidics-derived chondrocyte microspheroids promotes auricular cartilage regeneration
Microtia remains a major clinical challenge, as autologous costal cartilage transplantation—the current gold standard—suffers from donor-site morbidity and imprecise morphology, whereas synthetic implants are prone to immune rejection and structural collapse. Here, we present a biphasic composite…
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Journal Article
Atomically preserved MXene quantum dots as a redox-responsive nanoplatform for light-controlled bidirectional ROS engineering
MXene quantum dots (MQDs) combine the intrinsic reductive properties of MXenes with the photoactivity induced by quantum confinement, positioning them as promising agents for dynamic redox regulation in therapeutic applications. However, their translation into practice has been limited by…
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Journal Article
Orchestrating the immuno-chondrogenic microenvironment via a bio-inorganic hybrid microsphere system for tendon-to-bone healing
The structural failure of rotator cuff repair is largely attributed to fibrovascular scar formation driven by a persistent inflammatory microenvironment and insufficient fibrocartilage regeneration at the tendon-to-bone interface. To address this, a microfluidic-generated GelMA microsphere system…
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