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Materials Today Advances
Scopus
ISSN 2590-0498 · Elsevier · 748 articles in the index
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Journal Article
Light-switchable micro-nano platform based on lanthanide-doped Ni-MOF for on-demand drug release and photothermal therapy of diabetic wounds
The hyperglycemic microenvironment in chronic diabetic wounds predisposes them to tissue necrosis, while persistent inflammation impairs the function of reparative cells and disrupts the formation of new tissue, leading to a stagnation of the healing process. Current therapeutic strategies are…
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Journal Article
A pH-responsive Chitosan/PEGDA composite hydrogel encapsulating dihydromyricetin ZIF-8 nanoparticles for infarcted myocardial repair by inhibiting ferroptosis
Cardiomyocyte loss is substantial after myocardial infarction (MI). Given the heart's limited intrinsic regenerative capacity, this loss frequently triggers myocardial fibrosis, detrimental ventricular remodeling, and ultimately culminates in heart failure. Among post-MI cell death pathways…
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Journal Article
Cu nanoparticle sensitized MnO2 sonozymes for enhanced sonocatalytic therapy through cascade amplification of ROS production
Sonodynamic and chemodynamic therapy (SDT/CDT) based on the production of high cytotoxicity reactive oxygen species (ROS) for killing cancer cells are promising tumor treatment modalities owing to their non-invasiveness, specificity, and high penetration depth. Nevertheless, sonosensitizers and…
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Journal Article
A curved-mold assisted slow evaporation approach for uniform dye integration in commercial hydrogel lenses
Functionalities such as drug delivery, sensing, and selective wavelength filtering are often added to contact lenses through the incorporation of various additives. For color blindness correction, selective wavelength filtering dyes are often investigated for improving color differentiation. Here…
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Journal Article
A dimensionless rheology-based extrusion map as a predictive tool for hot-melt extrusion processability
Predicting the processability of polymeric materials in hot-melt extrusion remains a critical challenge in continuous manufacturing due to the complex transition from powder feeding to melt flow under dynamic processing conditions. In this work, we present a unified and predictive methodology for…
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Journal Article
A BBB-penetrated, microglia-targeted, and hypoxia-responsive nanogel for treating ischemic stroke
Ischemic stroke is the most common type of stroke, seriously endangering the lives and health of the population. The main treatment methods include thrombolysis and thrombectomy in the acute phase and drug therapy. Recent studies have found that inflammatory responses play a significant role in the…
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Journal Article
Non-destructive evaluation of thermally induced structural transformation in PET using terahertz time-domain spectroscopy
In this study, terahertz time-domain spectroscopy (THz-TDS) was used to inspect the thermally induced structural transformation of polyethylene terephthalate (PET). PET specimens with different structural states, including variations in free volume and crystallinity, were prepared by controlling…
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Journal Article
Coupled interfacial bonding and elastic mismatch effects on the thermal conductance enhancement in carbon nanohorn-reinforced fly ash geopolymers
Improving heat extraction performance and energy efficiency requires great efforts to develop new thermal conductive low-carbon materials. Here, a novel strategy for enhancing the thermal conductance of fly ash geopolymers through the incorporation of thermally conductive nanofillers including…
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Journal Article
Vacuum-enhanced dielectric elastomer counterpulsation for in-vivo diastolic augmentation
Cardiac assist devices based on dielectric elastomer actuators (DEAs) offer a promising alternative to conventional mechanical circulatory support by providing soft and adaptive mechanical assistance. However, existing DEA-based systems face significant limitations in energy efficiency and…
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Journal Article
Advanced dECM-based bioprinting strategy for tissue regeneration
The limitations of tissue injury repair, including donor shortages, immune rejection, and rehabilitation challenges, necessitate the development of functional substitute tissues that promote endogenous regeneration and can be produced at scale. This review focuses on the advancements in…
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Journal Article
Microfluidic-based mechanoporation for immune cell engineering: Principles, design, and applications in cell therapy
Cell therapy, particularly chimeric antigen receptor (CAR)-engineered immune cells, has emerged as a clinically validated strategy for tumor treatment, achieving remarkable outcomes in multiple malignancies. Despite this promise, a critical bottleneck in immune cell engineering lies in the…
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Journal Article
Enhanced broadband nonlinear optical properties of copper-functionalized SnSe nanosheets for laser pulse generation
Two-dimensional (2D) tin selenide (SnSe) nanosheets have emerged as promising candidates for photonic applications due to their suitable bandgap and excellent optical properties in the broadband infrared region. However, their low carrier mobility and thermal conductivity limit their expanded…
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Journal Article
Hydrogel-controlled release of BMAL1-enriched exosomes accelerates diabetic wound healing by promoting angiogenesis and regulating macrophage polarization through activation of the MAPK signaling pathway
Diabetic wounds are characterized by delayed healing due to impaired angiogenesis and dysregulated immune-inflammatory responses. In this study, we developed a novel therapeutic approach utilizing a 4ArmPEG-NHS/4ArmPEG-NH2 cross-linked hydrogel for the sustained delivery of exosomes (Exos) derived…
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Journal Article
Application of injectable hydrogels in immunotherapy via the cGAS-STING pathway for cancer and inflammatory disease treatment
Immunotherapy has emerged as a cornerstone in the treatment of diverse diseases, offering new avenues for improving patient outcomes across a broad clinical spectrum. Among various immune regulatory mechanisms, the stimulator of interferon genes (STING) pathway serves as a vital molecular bridge…
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Journal Article
A biomimetic physical-biological coupled bone organoid 3D culture system for bone repair
The osteogenic and angiogenic capabilities of bone defect implants affect the regeneration and repair of bone tissue. This study introduces a novel organoid material that simulates the physical and biological characteristics of bone. Hydroxyapatite was used as the implant material and was printed…
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Journal Article
Glial cell responses to particles derived from spinal implant materials
Spinal implants have been successfully used to treat various spine conditions. However, concerns remain regarding the release of ions and particles that can cause adverse host responses. Moreover, the biological response from cells of the central nervous system to implant wear particles is not well…
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Journal Article
α-Ketoglutarate-loaded extracellular vesicles restore OPA1-mediated mitochondrial function to reprogram macrophages and promote periodontal regeneration
Periodontitis is a persistent inflammatory disorder marked by gradual destruction of alveolar bone. Targeting macrophage polarization and mitochondrial metabolism represents a promising strategy for its treatment. Here, we developed engineered extracellular vesicles (AKG-EVs) by encapsulating…
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Journal Article
Sr2+ doped HA@PCL scaffold regulating reprogramming of macrophage to enhance osteogenesis and angiogenesis via ameliorating endoplasmic reticulum stress
The induction of angiogenesis and osteogenesis of bone defects still poses a challenge by bioactive materials without any growth factor. Modulating the bone immune microenvironment might be an effective approach to ameliorate the regeneration of vessels and bone. In this study, we construct…