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Kidney Medicine
Scopus
ISSN 2590-0595 · Elsevier · 1,095 articles in the index
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Journal Article
Growth Failure Associated With Parathyroid Hormone Levels in Pediatric Dialysis Patients: A Nationwide Cohort Study
Rationale & Objective: Growth failure is prevalent in pediatric dialysis patients. Physical growth is limited to a specific period, and missed interventions may cause lifelong growth retardation. We aimed to investigate the association of secondary hyperparathyroidism with short stature and height…
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Journal Article
ReNU Syndrome due to a de novo RNU4-2 Variant as a Novel Genetic Cause of Proteinuria
Proteinuria has been linked to several genetic disorders, providing valuable insights into its pathophysiology. ReNU syndrome, a recently described condition caused by heterozygous variants in the RNU4-2 gene, is characterized by intellectual disability, microcephaly, and multisystemic features…
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Journal Article
Chinese Herb-Induced Type II Crescentic Glomerulonephritis: A Case Report of Four Patients
Drug-induced type II crescentic glomerulonephritis is an uncommon but severe renal syndrome, rarely linked to pharmaceutical agents, with no established association to Chinese herbal medicines to date. In this case report, we described 4 patients who developed biopsy-confirmed type II crescentic…
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Journal Article
An Extremely Low-Birth-Weight Infant With Bone Fragility Due to Fanconi Syndrome
Fanconi syndrome is a generalized dysfunction of the renal proximal tubule, leading to growth failure and rickets during childhood. There are few reports of this syndrome in neonates, especially in extremely low-birth-weight infants. We present a case of an extremely low-birth-weight Asian girl…
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Journal Article
Depression and Advance Care Planning Among Japanese Patients Undergoing Hemodialysis: Japanese Dialysis Outcomes and Practice Pattern Study (J-DOPPS)
Rationale & Objective: Advance care planning (ACP) is crucial in end-of-life care. Data on ACP discussion among patients with end-stage kidney disease are limited. One study has suggested that depressive symptoms increase ACP discussion. Study Design: This study aimed to analyze the association…
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Journal Article
Nephron and Podocyte Metrics in Adolescents With a History of Low Birth Weight: A Three-Case Report
Low birth weight (LBW), which is indicative of impaired fetal growth, is associated with the development of both nephrons and podocytes, increasing the risk of kidney disease later in life. However, the clinical evidence remains limited. We herein reported 3 patients with a history of LBW who…
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Journal Article
Heat Stress and Kidney Injury: A Growing Concern Amidst Climate Change
Rising global temperatures owing to climate change have direct and harmful effects on kidney health, mainly through heat stress and related acute kidney injury. Despite growing clinical evidence, the nephrology community has yet to incorporate environmental stressors into risk models and guidelines…
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Journal Article
Systematic Review and Meta-analysis of the Predictive Performance of Stroke and Bleeding Prediction Models in Atrial Fibrillation Patients With Kidney Disease
Rationale & Objective: Patients with atrial fibrillation (AF) and chronic kidney disease (CKD) are at high risk for ischemic stroke (IS) and bleeding. The applicability of prediction models in this population remains debated. This study aimed to (1) identify external validations of CHA2DS2-VASc…
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Journal Article
Real-World Effectiveness of Ravulizumab Among C5 Inhibitor-Naive Patients With Atypical Hemolytic Uremic Syndrome: A Physician Panel-Based Chart Review (aHUS IMPACT Study)
Rationale & Objective: Atypical hemolytic uremic syndrome (aHUS) is a rare form of thrombotic microangiopathy (TMA) caused by complement dysregulation. Ravulizumab, a complement C5 inhibitor (C5i), is approved for aHUS; however, published evidence in a real-world setting is limited. Study Design…
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Journal Article
The Impact of Persistent Iron Overload and Ferritin Trend on the Clinical Outcome of Peritoneal Dialysis Patients: A Retrospective Study Over 10 Years
Rationale & Objective: Anemia is a major complication in chronic kidney disease. Although iron replacement therapies are commonly used, concerns about iron overload exist, for which data are limited, particularly in patients undergoing peritoneal dialysis (PD). This study investigated the impact of…
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Journal Article
Seronegative Cryoglobulinemic Glomerulonephritis Coexisting With Primary Sjögren Syndrome and HBV Infection: A Diagnostic and Therapeutic Challenge
Cryoglobulinemic glomerulonephritis (CryoGN) is most often caused by mixed cryoglobulinemia, encompassing both type II and type III forms. CryoGN is commonly associated with hepatitis C virus infection or primary Sjögren syndrome (pSS). We report a rare case of serum-negative CryoGN that was…
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Journal Article
Late-Onset Normotensive Thrombotic Microangiopathy and Pyoderma Gangrenosum Following Nine Years of Sunitinib Therapy: A Case Report
Sunitinib, a tyrosine kinase inhibitor used for metastatic renal cell carcinoma, is associated with various adverse effects. We present the case of a 60-year-old woman who developed biopsy-proven thrombotic microangiopathy and concurrent pyoderma gangrenosum after 9 years of sunitinib therapy. This…
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Journal Article
Oxalate Nephropathy in a Patient With Chronic Pancreatitis and Recent Surgery: A Clinical Conundrum
Calcium oxalate nephropathy is a rare condition with both primary and secondary causes. Primary hyperoxaluria, an inherited disorder, leads to liver oxalate overproduction, whereas secondary hyperoxaluria, or enteric hyperoxaluria, may be multifactorial and typically occurs during adulthood, with…
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Journal Article
Examining the Role of a Comprehensive eConsult System to Enhance Access to Nephrology Care
Rationale & Objective: A stagnant US nephrology workforce and rising chronic kidney disease (CKD) prevalence underscore the need for improved nephrology expertise accessibility. We examined nephrology consultation patterns in one health care setting with a comprehensive eConsult program in which…
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Journal Article
Functional Analysis of a Novel Pathogenic Glycine Amidinotransferase Mutant in Hereditary Fanconi Syndrome
The mutant glycine amidinotransferase (GATM) protein polymerizes into a characteristic crystal, resulting in mitochondrial dysfunction in proximal tubules and Fanconi syndrome with progressive kidney failure. We identified a novel hereditary Fanconi syndrome characterized by mutant GATM proteins in…
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Journal Article
How Far Is a Kidney Willing to Go? Kidney Transplant Outcomes Based on Distance Donor Kidney Travels to Transplant Centers
Rationale & Objectives: There are growing concerns over inequities and inequality in deceased-donor kidney access. The current allocation system emphasizes distance from the kidney donor, resulting in geographic disparities in kidney transplantation. Increasing the priority radius for…
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Journal Article
Cost-Effectiveness Analysis of Artificial Intelligence-Driven Risk Stratification in Patients With Diabetic Kidney Disease in the US Veterans Population
Rationale & Objective: Efficient risk stratification is essential to optimize care and allocate resources for treatment of diabetic kidney disease (DKD). This study evaluates the cost-effectiveness of an artificial intelligence-driven in vitro kidney disease risk assay (AIKD). Study Design…
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