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Current Research in Pharmacology and Drug Discovery
Scopus
ISSN 2590-2571 · Elsevier · 233 artikel di indeks
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Artikel Jurnal
Therapeutic potential, pharmacological role and molecular mechanisms of adelmidrol, an analogue of palmitoylethanolamide
Adelmidrol is a bioactive semi-synthetic compound with significant therapeutic potential, particularly in resolving inflammation since inflammation plays a key role in the pathogenesis of several diseases. The mechanisms of action of adelmidrol are multifaceted, involving interactions with specific…
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Neuroprotective effects of naringenin on nicotine-induced anxiety and depression: Involvement of monoaminergic systems, oxidative stress, and neuroinflammation on male rats
Introduction: Nicotine withdrawal during adolescence induces severe neurobehavioral disturbances and neurochemical alterations, including anxiety, depression, affective dysregulation, oxidative stress, and neuroinflammation. Current therapeutic options for managing nicotine dependence remain…
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Synergistic effect of oxaliplatin and nanocurcumin in dendrosomal carrier to inhibits ovarian cancer cells invasion and metastasis through the long non-coding RNA MEG3
Background: Ovarian cancer (OC) remains one of the most lethal gynecological malignancies worldwide. The long non-coding RNA MEG3 (Maternally Expressed Gene 3), located on chromosome 14q32.3, has been identified as a tumor suppressor in various cancers. This study investigated the impact of…
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Anti-Shigella activity and killing kinetics of compounds from MMV Pathogen and COVID Boxes: Identifying leads against Shigellosis
Background: Shigellosis is a leading diarrheal disease, posing critical public health challenges in low- and middle-income countries. Rising antibiotic resistance exacerbates treatment limitations. Methods: We screened 560 compounds from the MMV Pathogen and COVID Boxes for in vitro activity…
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Therapeutic effects of vitamin D and omega-3 supplementation on HFHS diet-induced endothelial dysfunction in Wistar rats
Background: Obesity impairs cardiovascular health through endothelial dysfunction, which is exacerbated by high-fat high-sugar (HFHS) diets through mechanisms involving chronic inflammation, oxidative stress, and insulin resistance. Nutritional interventions, specifically vitamin D (VD) and omega-3…
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Salvianolic acid B decreases oxidative stress and alleviates the tumor-promoting effects of arecoline in oral cancer
Arecoline, which is a primary alkaloid in areca nuts, contributes in key ways to the development of oral submucous fibrosis and the subsequent oral cancer through the induction of oxidative stress, promotion of fibrosis, and activation of oncogenic signaling. Salvianolic acid B (SAB) is the most…
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Artikel Jurnal
Targeting telomere dynamics with plant-derived compounds: Molecular strategies against aging
Telomeres, the repetitive DNA–protein complexes capping eukaryotic chromosomes, preserve genomic stability and regulate cellular replicative capacity. Progressive telomere shortening, coupled with diminished telomerase activity, is a hallmark of aging and contributes to cellular senescence, tissue…
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Melatonin combined with antineoplastic drugs or natural products for cancer treatment: An update
Drug combinations have shown promise in suppressing drug resistance, improving drug efficacy, and reducing side effects in anticancer therapy. Considering that the anticancer activity of melatonin may be due to its antiproliferative, antioxidant, and immunomodulatory activities, the combined…
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MAO-B inhibition by selegiline blunts cardiac functions improved by high-fat diet: Role of inflammation, apoptosis, and calcium-handling
Background: Obesity is a major risk factor for the development of cardiovascular disease. However, recent research shows that moderate obesity reduces the risk of developing cardiovascular disease. We evidenced before that MAO-B inhibitor selegiline reduced visceral adiposity. Aim: Therefore, our…
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A 10-year interval of cardiovascular effects of albuterol in asthma management: Graphical review
Asthma is a widespread chronic respiratory disease that requires effective management to reduce exacerbations and improve patient outcomes. Albuterol (salbutamol), a short-acting beta-2-agonist (SABA), remains a mainstay treatment for acute symptom relief due to its rapid bronchodilatory effect…
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BCS II/IV antibiotics blended with SPEEK nanofibrous mat as an alternative for recurrent wound care: An in vitro and in vivo assessment
The repeated dressing changes, especially for infected wounds and those with high exudate, and applying drugs daily, are huge demands in wound management. Sustained and regulated medication release of BCS II/IV antibiotics improves chronic wound therapy. The poor solubility and absorption of…
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Exploring the role of sex in asthma and COPD pharmacological treatment
Sex is a fundamental determinant in pharmacology, influencing disease prevalence, severity, and therapeutic responses. Differences in pharmacokinetics and pharmacodynamics between men and women contribute to variations in drug efficacy and safety profiles. While sex refers to biological and…
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Fragment-based drug discovery: A graphical review
Three decades after its introduction, fragment-based drug (or lead) discovery (FBDD or FBLD) has become a mature and powerful strategy for generating novel leads, offering distinct advantages for challenging or previously “undruggable” targets where traditional screening (e.g., high throughput…
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Cyclodextrin-based therapeutics delivery systems: A review of current clinical trials
This review highlights the current status of cyclodextrin-based formulations tested in human participants, highlighting ongoing clinical research in this area. It provides a comprehensive link between the structure, properties, and clinical applications of these formulations, bridging the gap…
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Pharmacogenetics association with long-term clinical evolution in a kidney transplant patients cohort
Background: Pharmacogenetic variability has been reported to influence the efficacy and safety of immunosuppressive therapies in early stages of kidney transplantation. This study investigates long-term associations between pharmacogene variants and clinical outcomes in a cohort of kidney…
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Unveiling the mechanisms of synthetic compounds against Candida auris: An integrative review
The multidrug-resistant fungal species Candida auris has drawn attention from across the world due to its capacity to elude traditional therapies and flourish in medical environments. Its resilience, which includes biofilm development and efflux-mediated drug resistance, highlighted the need for…
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The simultaneous activation of μ- and δ-opioid receptors by (−)-2S-LP2 rescues allodynia with the contribution of TGF-β1 signaling in a rat chronic constriction injury model
In neuropathic pain (NP), a dysregulation of glial functions in the central and peripheral nervous systems has been described, and the balance between pro-inflammatory and anti-inflammatory mediators is lost in the transition from acute to chronic pain. This raises the possibility to resolve pain…