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Current Research in Biotechnology
Scopus
ISSN 2590-2628 · Elsevier · 391 articles in the index
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Journal Article
Stochastic optimization of Gradient Boosting Decision Trees for interpretable prediction of heavy metal adsorption onto biochar
Predicting the heavy metal adsorption capacity of biochar is a significant challenge due to complex physicochemical mechanisms and the limitations of traditional experimental approaches. This study aimed to develop and validate a robust, interpretable machine learning framework by optimizing…
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Journal Article
Efficacy and safety of Qinwei Oral Granules for acute gouty arthritis: A multicenter, randomized, double-blind, placebo-controlled phase III trial
Background: Traditional Chinese Medicine formulations such as Qinwei Oral Granules (QWG) have shown analgesic and anti-inflammatory effects in gout; however, high-quality placebo-controlled evidence remains limited. Methods: In this phase III, multicenter, randomized, double-blind…
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Journal Article
Efficient polyhydroxyalkanoates production by anoxic mixed microbial cultures in two-stage sequencing batch reactors: conceptual validation and microbial insights
Single-stage microbial production of polyhydroxyalkanoates (PHA) requests concurrent microbial selection, biomass maintenance, and intracellular polymer storage within the same unit, thereby hindering the attainment of high-level PHA storage. Two-stage sequencing batch reactors (SBRs), designated…
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Journal Article
IgA/IgM chromatographic depletion enables efficient 20-nm virus nanofiltration of mini-pool caprylic-acid IgG: A proof-of-concept study
Shortages of human plasma-derived immunoglobulin G (IgG) in low- and middle-income countries, driven by a lack of local plasma fractionation capacity, represent a serious obstacle to the treatment of primary and secondary immunodeficiencies, as well as other diseases for which IgG therapy is…
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Journal Article
Affinity-based recovery of metabolically active microbial cells using BioOrthogonal Non-Canonical amino acid tagging
Selective identification of translationally active cells remains a key challenge in linking microbial function to population dynamics. Bioorthogonal non-canonical amino acid tagging (BONCAT) enables pulse-labelling of newly synthesized proteins in live cells, providing a time-resolved of…
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Journal Article
Combining clinical cyclophosphamide with a novel Lactobacillus strain enhances apoptosis in cervical cancer cells
Background: Cervical cancer remains a major global health burden among women. Despite the effectiveness of chemotherapeutic agents such as Cyclophosphamide (CTX), severe systemic toxicity and drug resistance limit their clinical potential. This study investigated the synergistic antitumor effects…
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Journal Article
Continuous fermentation in food biotechnology: bridging the gap between batch and continuous processing
Continuous fermentation can improve productivity, resource efficiency, and product consistency in food biomanufacturing, yet its industrial adoption remains limited compared with pharmaceutical manufacturing. This review analyzes the current state of continuous submerged fermentation for food…
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Journal Article
3D bioprinting for reproducing the tumor microenvironment in cancer research models
The tumor microenvironment (TME) is an intricate network of extracellular matrix (ECM) components with different stromal cells, notably immune cells, adipocytes, fibroblasts, endothelial cells that influence cancer progression and therapeutic response. Traditional 2D models fail to replicate the…
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Journal Article
Sustainable ultrasound-assisted extraction of Miliusa velutina stem bark: Optimization, in vitro-in silico anti-metabolic syndrome evaluation, and life cycle assessment
Metabolic syndrome (MetS) is associated with oxidative stress, lipid-glucose dysregulation, and chronic inflammation. Miliusa velutina (Annonaceae), a Southeast Asian plant, remains largely unexplored for its biological potential. This study developed a sustainable ultrasound-assisted extraction…
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Journal Article
Comparative evaluation of chromium methionine chelate and Nano chromium in alleviating Zearalenone-Induced oxidative stress
Zearalenone, a mycotoxin from Fusarium fungi found in contaminated feed, poses toxicity risks to livestock. The administration of antioxidant compounds has emerged as a potential approach for mitigating zearalenone-induced toxicity. This study evaluated the effectiveness of chromium-methionine…
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Journal Article
Synthesis of 2-aryl substituted benzimidazoles as bifunctional agents combining antiparasitic activity with radical-scavenging properties against Trichinella infection
Purpose: The aim of this research was to synthesize a series of 2-arylbenzimidazoles and evaluate their anti-Trichinella activity and free radical scavenging potential. Methods: Three complementary synthetic approaches were applied, and structures were confirmed by spectroscopic methods and DFT…
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Journal Article
Deciphering the therapeutic potential of 3,4-Dihydrocoumarin in cervical cancer: A combined network pharmacology and in vitro study
Background: Coumarin derivatives represent a versatile scaffold for anticancer drug discovery. This study explored the therapeutic potential of 3,4-dihydrocoumarin (3,4-DHC), a major bioactive non-curcuminoid metabolite from Curcuma caesia, against cervical carcinoma. Methods: Phytocomponents were…
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Journal Article
Harnessing genome editing for post-harvest improvement of crops: a comprehensive bibliometric and literature review
Post-harvest losses represent a critical challenge to global food security, necessitating innovative solutions to enhance crop longevity, quality, and resilience. This review provides a comprehensive analysis of the emerging applications of genome editing technologies, particularly CRISPR/Cas9, for…
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Journal Article
Artificial intelligence and machine learning across vaccine lifecycle: a systematic review
Introduction: Recurrent global health emergencies have intensified interest in the application of artificial intelligence (AI) and machine learning (ML) to all stages of the vaccine life cycle. This systematic review synthesizes the available evidence and maps the current breakthroughs, persistent…
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Journal Article
Protective effects of microencapsulated Ocimum basilicum essential oil on Cisplatin-Induced hepatic Damage: Modulation of oxidative stress and liver enzymes
Cisplatin (CP) is a widely utilized chemotherapeutic agent; however, its clinical effectiveness is often limited by dose-dependent hepatotoxicity, which arises from oxidative stress and inflammation. In contrast, bioactive compounds derived from medicinal plants exhibit promising hepatoprotective…
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Journal Article
Acoustic signatures of microalgal growth: ultrasonic velocity and attenuation as quantitative biomass indicators in Spirulina maxima
Accurate, real-time measurement of microalgal biomass is vital for optimizing photobioreactor performance and advancing bioprocess monitoring technologies. This study systematically investigated the acoustic signatures of Spirulina maxima (S. maxima) by measuring sound velocity and attenuation at 1…
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Journal Article
Novel 2-aminobenzimidazolyl-1-hydrazones with antileukemic activity: Potent alternatives to imatinib and ibrutinib
Chronic leukemias are serious, life-threatening blood malignancies that require long-term treatment. Current drug development focuses on precise, targeted therapies to overcome the limitations of conventional chemotherapeutics, such as low efficacy and adverse side effects. In this study, we…
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Journal Article
Optimization of clove oil hydro-distillation: Effects of process parameters on yield and bioactive compound recovery
This study focuses on the experimental optimization of clove (Syzygium aromaticum) oil extraction via hydro-distillation, with particular emphasis on the recovery of biologically active compounds responsible for the antioxidant and antibacterial properties of targeted oil. The objective was to…
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Journal Article
Biofilm of Oenococcus oeni on yeast derivatives: An innovation to trigger malolactic fermentation and modulate the molecular fingerprint of wines
The wine industry is undergoing a major transformation and faces a number of challenges. One of these is climate change, which will significantly increase the alcohol content of wines over the coming decades. This rise in alcohol content will be particularly detrimental to the yeasts and bacteria…