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Cancer Research, Statistics, and Treatment
Dikeluarkan Scopus 2023
ISSN 2590-3233 · Wolters Kluwer Medknow Publications · 903 artikel di indeks
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Artikel Jurnal
The International Council for Harmonisation E6 (R3) revision and its impact on clinical research practice: A narrative review
The International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use (ICH), established in April 1990, has released an updated version of its ICH E6 guidelines for Good Clinical Practice (GCP). This new version, ICH E6 (R3), replaces ICH E6 (R2) and introduces…
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Artikel Jurnal
Prospective study comparing positron emission tomography/computed tomography (PET/CT) with conventional staging workup T3, T4 breast carcinoma
Background: The staging workup for T3/T4 breast carcinoma requires multiple imaging sessions. Using 18F-FDG PET/CT (18F-fluorodeoxyglucose positron emission tomography/computed tomography) as a single modality may streamline diagnosis, reduce hospital visits, expedite treatment initiation, and…
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Outcomes and toxicities of triple metronomic chemotherapy with low-dose nivolumab and axitinib in unresectable, recurrent, and metastatic head-and-neck squamous cell carcinomas: A real-world retrospective analysis from a resource-constrained setting
Background: This study aimed to evaluate whether the addition of an anti-vascular endothelial growth factor (VEGF) agent, axitinib, to oral metronomic chemotherapy and low-dose nivolumab could improve survival outcomes without increasing toxicities in patients with advanced, unresectable, or…
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Artikel Jurnal
Outcomes of carboplatin-paclitaxel induction chemotherapy followed by chemoradiotherapy in locally advanced oropharyngeal and hypopharyngeal cancer: A retrospective study in a resource-limited setting
Background: The role of induction chemotherapy (ICT) in locally advanced oropharyngeal and hypopharyngeal squamous cell carcinoma (SCC) remains debated, particularly in resource-limited settings. Objective: The primary objective was to evaluate the locoregional response to carboplatin- and…
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Artikel Jurnal
Erlotinib in EGFR TKI-progressed lung cancer: Retrospective real-world insights from a tertiary cancer center in South India
Background: Osimertinib benefits patients with non-small cell lung cancer (NSCLC), progressing on first-line epidermal growth factor receptor (EGFR) tyrosine-kinase-inhibitors (TKIs), but high cost restricts access in low- and middle-income countries (LMICs). We evaluated erlotinib rechallenge in…
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Artikel Jurnal
Panoramic view of head-and-neck cancer at Western Maharashtra’s rural tertiary cancer care center: A prospective observational study
Background: Despite advances in diagnostics and therapeutics, outcomes of head-and-neck cancer (HNC) remain dismal. Rural patients and their family caregivers (FCGs) face unique challenges that remain underexplored. Objectives: The primary objective was to study the clinicodemographic profile…
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Artikel Jurnal
A prospective, open-label, randomized, crossover study to compare the pharmacokinetics of crushed methotrexate with that of the tablet formulation in patients with head-and-neck cancer
Background: Crushing solid dosage forms is often required in patients with swallowing difficulties; however, the pharmacokinetic (PK) impact of this alteration is not well-studied. Objective: The primary objective was to compare the PK of crushed methotrexate tablets suspended in water versus whole…
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Artikel Jurnal
Efficacy and toxicity of immune checkpoint inhibitors: A retrospective analysis from a single institution in Eastern India
Background: Immune checkpoint inhibitors (ICIs) have transformed the management of several solid malignancies. Real-world data—particularly from low- and middle-income countries—remain limited and are essential to understand outcomes across heterogeneous patient populations. Objectives: Our primary…
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Artikel Jurnal
Preliminary psychometric properties of a multidimensional comprehensive screening tool (MCOST) for early detection of psychosocial, behavioral, and neurocognitive deficits in pediatric cancer survivors: A prospective observational study
Background: Childhood cancer and its treatment produce complex, multilayered effects across active treatment, maintenance, and survivorship phases. The focus of care has shifted toward early identification of difficulties related to biological functioning, somatic complaints, neurocognitive…
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Artikel Jurnal
Clinical profile, treatment outcomes, and impact of positive nodes in patients treated for penile carcinoma at a tertiary cancer center: A retrospective study
Background: Penile carcinoma is a rare and aggressive malignancy with variable incidence and survival outcomes due to geographical and socioeconomic variation. Objectives: The primary objective was to study the clinical profile, treatment pattern, and surgical complications in patients with penile…
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Artikel Jurnal
Residual cancer burden following neoadjuvant chemotherapy in breast cancer: A retrospective analysis by receptor subtype
Background: Neoadjuvant chemotherapy (NACT) plays a key role in treating locally advanced breast cancer. While pathological complete response (pCR) is a strong prognostic indicator, residual cancer burden (RCB) offers a more comprehensive assessment by quantifying residual disease. Objectives: The…
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Prognostic factor and disease-free survival analysis of patients with oral tongue cancer in Bihar, India: A hospital-based prospective study
Background: Tongue is the most common subsite of oral cavity carcinoma in Bihar, and disease-free survival (DFS) depends upon multiple clinical and treatment-related factors. Objectives: The primary objective was to estimate the 3-year DFS of patients with oral tongue cancer from Bihar, India. The…
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A community health worker-led, population-based cancer education and screening strategy in a high-burden, resource-constrained setting in India: A retrospective cohort study
Background: The uptake of screening for three common cancers at the population level remains very low despite the implementation of nationwide screening for noncommunicable diseases in India. Objectives: The primary objective was to assess the cancer care cascade of a community health worker…
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Artikel Jurnal
Clinical utility of serum procalcitonin for suspected sepsis in patients with cancer: A prospective observational study
Background: Clinical utility of a single serum procalcitonin (PCT) measurement in patients with cancer presenting with a suspected infection episode remains uncertain. Objectives: The primary objective was to evaluate the diagnostic performance of PCT for bloodstream infection (BSI) and sepsis in…
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Artikel Jurnal
Age-related differences in presentation and outcomes of breast cancer: A prospective, comparative study of Colombian patients younger and older than 40 Years
Background: Breast cancer incidence is rising in Latin America, with 17,018 cases reported in Colombia in 2022. Although predominant in women > 40 years, the disease is notably more aggressive in younger patients. Objectives: The primary objective was to compare health outcomes (stage at diagnosis…