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Journal of Advanced Biotechnology and Experimental Therapeutics
Scopus
ISSN 2616-4760 · Bangladesh Society for Microbiology, Immunology, and Advanced Biotechnology · 381 artikel di indeks
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Artikel Jurnal
Deciphering the anti-cancer mechanism of ferulic acid in gastrointestinal cancers using network pharmacology, simulations, and in vitro validation
Ferulic acid (FA) was reported for its chemoprotective anticancer properties in various cancers, including lung and breast cancers. However, the exact molecular mechanism of FA targeting the JAK-STAT pathway in gastrointestinal (GI) cancers such as colon and gastric cancers, has yet to be explored…
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Artikel Jurnal
Therapeutic potentials of vitamin C, zinc, and selenium in DSS-induced colitis in mice: Zinc combination exhibits superior synergistic effects
Standard treatments of inflammatory bowel diseases frequently demonstrate limited long-term efficacy and are associated with significant side effects, necessitating the exploration of safer therapeutic alternatives. This study aimed to compare the therapeutic efficacy of vitamin C (VitC)…
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Artikel Jurnal
Serological prevalence of herpes virus infection and PTEN levels in patients with autism spectrum disorder
Autism spectrum disorder (ASD) is a neurodevelopmental condition of the central nervous system (CNS) that presents with severe communication problems of unknown cause. Few studies have explored the role of some herpesviridae members as potential etiological factors of ASD and phosphatase and tensin…
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Artikel Jurnal
Multidrug transporters P-GP, MRP1, and ABCG2 in chemoresistant breast and colorectal cancer cells—who takes the lead?
Despite significant advances in the discovery and efficacy of anticancer drugs, chemoresistance remains a major issue in cancer treatment and management. Hyperactivity of efflux pumps is one of the key mechanisms through which cancer cells acquire chemoresistance. This study investigates the…
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Artikel Jurnal
Novel molecular-based techniques of Cryptococcus identification in Cryptococcal meningitis: Recent advances and prospects
Meningitis is still a worldwide issue caused by Cryptococcus, also known as Cryptococcal meningitis. Cryptococcus infection is dependent on the host's immune condition. Due to its opportunistic type, this fungus utilizes its evasion mechanism to survive when the immune system is weakened. Detecting…
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Artikel Jurnal
Effect of Caesalpinia sappan and Annona muricata isolates on VEGF-mediated angiogenesis in HeLa cells
Angiogenesis plays an important role in the growth of cancer cells, including cervical cancer. The compounds in sappan wood (Caesalpinia sappan L.) and soursop leaves (Annona muricata L.) have potential anticancer properties. The objective of this study was to evaluate the effect of sappan wood and…
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Artikel Jurnal
Association of pus cells with sperm abnormalities in patients with sub-fertility
Sub-fertility is one of the most common problems in men. Neutrophils represent the first immune cells arriving at the site of inflammation, and they turn into pus cells at the site of inflammation. Thus, the present study aimed to study the association of pus cells with sperm cell abnormalities and…
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Artikel Jurnal
Microbial determinants of endodontic treatment failure: A shotgun metagenomic study linking dysbiosis to systemic comorbidities
Post-treatment endodontic infections remain a major clinical challenge driven by microbial persistence. The influence of host comorbidities and gender on the endodontic microbiome, resistome, and virulence repertoire remains poorly understood. This study profiled microbial ecology, antimicrobial…
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Clinicopathological and histopathological investigations of canine parvovirus infection in naturally infected dogs in Bangladesh
Canine parvoviral enteritis (CPE) is a highly contagious and potentially fatal viral disease affecting dogs, particularly puppies (less than 3-6 months). Its prevalence is increasing due to increased pet ownership and rapid urbanization in areas like Bangladesh. The disease manifests in enteric and…
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Artikel Jurnal
Antimalarial drug discovery and development: Assay system challenges and the translational relevance of Plasmodium knowlesi–baboon model
Drug resistance has rendered most of the antimalarial drugs ineffective. In addition, utilization of some of the antimalarial drugs has been limited by their toxic effects due to prolonged treatment regimens. The long treatment period affects compliance, which contributes to the development of drug…
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Artikel Jurnal
Effect of mesenchymal stem cells on reducing melanin levels in response to UV radiation in male C57BL/6 mice
Melanin is a pigment produced by melanocytes through polymerization and oxidation during melanogenesis. It is present in the skin, hair, and eyes as a natural bodily mechanism, although its levels can increase following damage. Ultraviolet (UV) radiation activates melanogenesis, leading to excess…
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Artikel Jurnal
Phenotypic and genotypic antimicrobial resistance patterns of Salmonella isolated from selected commercial layer farms in two districts of Bangladesh
Salmonella spp. is a major foodborne pathogen in poultry. The rise of multidrug-resistant (MDR) strains poses a serious threat to both animal and public health. The current study evaluated the prevalence, antimicrobial susceptibility, and molecular resistance traits of Salmonella spp. from four…
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Artikel Jurnal
Biochemical, histopathological, and genotoxic effects of zinc oxide nanoparticles, bacteriocin, and their composite on albino mice
Nanotechnology seems to be a valuable strategy to improve the physicochemical properties of the bacteriocins, although comprehensive toxicity studies, especially in vivo, are limited. Therefore, the objective of the current study was to investigate the lethal and the sub-chronic influences of…
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Artikel Jurnal
Growth inhibitory action of red Trapa natans shell methanolic extract in Ehrlich ascites carcinoma cells by inducing apoptosis through inactivation of NF-kB
Trapa natans L., commonly known as water chestnut, is a small aquatic herb belonging to the family Trapaceae. Its fruit is valued for both nutritional and pharmaceutical properties. This study investigated the anticancer potential of Red Trapa natans shell methanolic extract (RTNSME) against…
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Artikel Jurnal
Immunohistochemical expression of dual inhibitory natural killer cell receptors NKG2A/CD94 and KIR/CD158 in endometrial cancer
Endometrial cancer (EC) is among the most prevalent gynecological cancers globally and is recognized as an immunologically regulated tumor in which the tumor microenvironment contributes to immune escape. Natural killer (NK) cells are essential mediators of antitumor immunity; however, their…
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Artikel Jurnal
Phytochemical composition, hematinic activity, and in silico prediction of bioactive compounds in ethanolic leaf extracts of Hibiscus acetosella
Anaemia affects nearly 1.74 billion people globally, with increased risk of mortality and severe morbidity in developing countries. Medicinal plants have the potential as alternative sources of therapeutic compounds for the management of anaemia, because they are accessible, affordable, and without…
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Artikel Jurnal
Synergistic effects of moringa leaf extract and atorvastatin on protection against hyperlipidemia-induced testicular damage in male rats
Hyperlipidemia induces oxidative stress, leading to up-regulation of hepcidin, iron deposition, and impaired spermatogenesis. The current investigation examines the beneficial effects of Moringa oleifera leaf extract and atorvastatin on hyperlipidemia-induced physiological and histological changes…
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Integrated anticoagulant and antiplatelet activities of a phytochemically standardized scutellarin-rich fraction in rats
Plant-derived flavonoids may modulate both coagulation proteases and platelet activation, but integrated evidence across the platelet-coagulation interface remains limited. This study evaluated a phytochemically standardized scutellarin-rich fraction (SRF) using complementary plasma, platelet…
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Artikel Jurnal
Dose-dependent effects of soybean and mustard oils on hematobiochemical and histopathological changes in mice
Soybean oil (SO) is used worldwide, whereas mustard oil (MO) consumption is generally limited to South Asia. Nevertheless, the organ-damaging effects of these substances at multiple doses over time have not been well studied. This study evaluated the hematobiochemical and histopathological effects…
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Artikel Jurnal
Melanogenesis effect of Thai rice bran extract in B16F10 melanoma cells
Melanogenesis is regulated primarily by tyrosinase (TYR) and microphthalmia-associated transcription factor (MITF), making safe natural melanogenic stimulators desirable for cosmetic applications targeting hypopigmentation and hair graying. Rice bran contains bioactive compounds and minerals with…