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Gastrointestinal Disorders
Scopus
ISSN 2624-5647 · MDPI AG · 345 artikel di indeks
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Artikel Jurnal Teks lengkap
Elevated Plasma Adrenomedullin Levels in Patients with Unresectable Advanced Gastrointestinal Cancers
Background/Objectives: Adrenomedullin (AM) is a circulating peptide involved in tumor progression, angiogenesis, and fibrosis. However, its clinical utility as a biomarker in gastrointestinal cancers remains unclear. Methods: This single-center prospective observational study included patients with…
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Feasibility of Transitioning Adults with Mild-to-Moderate Reflux from Proton Pump Inhibitors to a Patented Papaya–Oat Food Supplement: A Single-Arm Pilot Study
Background: Proton pump inhibitors (PPIs) serve as efficacious therapies for acid-related conditions; nonetheless, the possibility of unwarranted prolonged usage has led to heightened focus on PPI management and suitable deprescribing practices. Investigating supportive non-pharmacological…
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Metabolic and Bariatric Surgery Before Kidney Transplantation: Referral Considerations, Access Outcomes, Procedure Choice, Safety, and Evidence Gaps—A Systematic Review and Exploratory Meta-Analysis
Background/Objectives: Obesity can delay kidney-transplant listing, and metabolic and bariatric surgery (MBS) may help address this barrier, but its role, timing, and procedure choice are not established for every candidate. We evaluated transplant-access outcomes, failed pathways, bariatric…
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The Emirates Gastroenterology and Hepatology Society Consensus Recommendations for the Diagnosis and Management of Adults with Eosinophilic Esophagitis in the United Arab Emirates: A National Delphi Study
Background: Eosinophilic esophagitis (EoE) is a chronic, immune-mediated esophageal disease characterized by symptoms of esophageal dysfunction and eosinophil-predominant inflammation. Increasing recognition of EoE and advances in its diagnosis and management have highlighted the need for locally…
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Cross-Cultural Adaptation and Structural Validation of the Arabic Fecal Incontinence Score in Egyptian Colorectal Disease Patients
Background/Objectives: Fecal incontinence (FI) is an underrecognized complication of inflammatory bowel disease (IBD) and colorectal neoplasia that substantially impairs quality of life. This study translated, culturally adapted, and validated the Arabic Vaizey Incontinence Score while evaluating…
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Public Awareness, Label Literacy, and Consumer Behavior Regarding Gluten-Free Products in Arar, Saudi Arabia: Implications for the Supportive Environment of Immune-Mediated Gastrointestinal Disorders
Background/Objectives: Community-level knowledge, food-label literacy, and consumer perceptions may shape the environment in which medically indicated gluten-free diets are followed. This study assessed prior exposure to the term “gluten,” ingredient-label literacy, perceived gluten-free product…
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Feeding Beyond Diagnosis: Parental Beliefs and Dietary Practices Among Children at Familial Risk for Celiac Disease
Background/Objectives: Celiac disease (CD) is a chronic immune-mediated disorder triggered by gluten ingestion in genetically predisposed individuals with higher prevalence among first-degree relatives. Despite its hereditary risk, little is known about how parents with at least one child with CD…
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A Pyogenic Liver Abscess Masquerading as Advanced Hepatocellular Carcinoma: Diagnostic Pitfalls of LI-RADS 5 in a Non-Cirrhotic Patient and Vascular Complications of Percutaneous Drainage
Background: Liver abscesses represent uncommon yet potentially life-threatening infections of the hepatic parenchyma. Their imaging appearances can vary widely, and—in rare instances—may closely resemble hepatocellular carcinoma (HCC) on multimodality imaging. We report a case of pyogenic liver…
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Autoimmune, Inflammatory, Autonomic and Enteric Measurements in Patients with Symptoms of Gastroparesis
Background/Objectives: Gastroparesis is a disorder in which individuals experience dysfunctional gastric motor symptoms, but the underlying etiology is unclear. This exploratory study investigates autoimmune, inflammatory, metabolic, autonomic, and enteric (AIMAE) abnormalities in patients with…
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Hemopatch Serosal Reinforcement of Colocolic Anastomoses in Elective Left Colectomy: Feasibility, Safety and Anastomotic Leak Patterns in a Single-Centre Cohort
Background and Objectives: Anastomotic leak after left-sided colectomy has not declined despite refinements in technique and patient selection, prompting interest in whether local reinforcement might influence the clinical course of leaks that occur rather than their occurrence. We describe the…
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Prevalence of Vitamin D Deficiency and Its Association with Disease Activity in Patients with Inflammatory Bowel Disease in Albania
Background: Patients with inflammatory bowel disease (IBD) are prone to low vitamin D levels; however, data from Southeast Europe on this topic remain sparse. We measured serum 25-hydroxyvitamin D [25(OH)D] concentrations in Albanian patients with inflammatory bowel disease (IBD) to determine the…
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Hepatocellular Drug-Induced Liver Injury Fulfilling Hy’s Law After Amoxicillin–Clavulanate Re-Exposure in an Elderly Saudi Man: A Case Report and Literature Review
Background: Amoxicillin–clavulanate (AC) is the antibiotic most frequently implicated in idiosyncratic drug-induced liver injury (DILI) worldwide, and it characteristically produces a cholestatic or mixed pattern in older adults. A predominantly hepatocellular presentation is distinctly less common…
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Sexually Transmitted Infections of the Colon—Clinical Picture, Endoscopic Features, and Laboratory Diagnosis: A Practical Review for the General Practitioner
Sexually transmitted infections (STIs) are common and probably underreported causes of proctitis and colitis. Bacterial (chlamydia, gonorrhoea, syphilis, Mycoplasma genitalium), viral (herpes simplex virus, mpox), and amoebic (Entamoeba histolytica) pathogens can cause inflammatory proctitis or…
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Site of Gastrointestinal Bleeding in Patients on Direct Oral Anticoagulants Versus Aspirin Monotherapy: A Single-Centre Retrospective Cohort Study
Background: Gastrointestinal (GI) bleeding is a recognised complication of long-term antithrombotic therapy. Whereas the overall bleeding risk associated with direct oral anticoagulants (DOACs) and low-dose aspirin has been extensively characterised, the anatomical distribution of bleeding lesions…
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Alpha-Gal Syndrome and the Gastrointestinal Tract: Epidemiology, Clinical Phenotype, Diagnosis, Management, and the Case for a Public Health Response
Alpha-gal syndrome (AGS) is a tick-induced, IgE-mediated hypersensitivity to the oligosaccharide galactose-α-1,3-galactose (α-gal), which is expressed on glycoproteins and glycolipids of non-primate mammals but absent in humans. Gastrointestinal (GI) symptoms dominate the clinical presentation in a…
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Genetic Screening and Lifestyle Prevention Strategies for Coeliac Disease: A Review of International Clinical Practice Guidelines
Background: Coeliac disease (CD) is a highly heritable autoimmune disease. Given the high risk among first-degree relatives, early screening and prevention are essential, yet clinical guidelines vary. This review analyzed clinical practice guidelines issued by leading European, British, and North…
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Anatomical Reconstruction After Metabolic Bariatric Surgery (MBS): Indications and Biochemical Responses in Post-Bariatric Hyperinsulinemic Hypoglycemia Patients—A Single-Center Case Series
Introduction: Anatomical gastrointestinal reconstruction following metabolic bariatric surgery (MBS) is a revisional procedure used for refractory complications, including malnutrition, intractable reflux, recurrent marginal ulcer disease, and post-bariatric hyperinsulinemic hypoglycemia (PBHH)…
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Effect of a Sequential Butyrate–Probiotic Administration on Symptoms and Stool Consistency in Patients with Irritable Bowel Syndrome: A Randomized Controlled Study
Background: Dysbiosis, mucosal inflammation and increased intestinal permeability have been implicated in the pathophysiology of irritable bowel syndrome (IBS). Objective: To evaluate the effectiveness of a sequential butyrate–probiotic administration in reducing symptoms and improving stool…
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Systematic Review of Malignancy Risk with Biologic, Advanced Small-Molecule, and Thiopurine Therapies for Inflammatory Bowel Disease
Patients with inflammatory bowel disease (IBD) often require long-term immunosuppressive or advanced therapy, raising concerns about treatment-associated malignancy risk. This systematic review evaluated malignancy outcomes associated with biologic, advanced small-molecule, and thiopurine therapies…
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Spontaneous Bile Duct Perforation in Children: A Systematic Review of 209 Cases and Practical Diagnostic and Management Considerations
Background/Objectives: Pediatric spontaneous or non-traumatic extrahepatic bile duct perforation (SBDP) is a rare cause of bile ascites and biliary peritonitis. We aimed to characterize presentation, diagnosis, management, outcomes, and summarize practical management considerations. Methods: A…