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Analytical Science Advances
Scopus
ISSN 2628-5452 · Wiley-VCH · 281 artikel di indeks
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Artikel Jurnal
Multimodal Analytical Platform Coupled With Biological Assays Unravels Tissue‐Specific Chemical Profiles, Spatial Metabolite Distributions and Bioactivities of Root Xylem and Root Bark of Tripterygium wilfordii
ABSTRACT Characterising chemical and biological differences among different tissues of medicinal plants is important for understanding their tissue‐specific characteristics and medicinal efficacy. The root xylem (RX) and root bark (RB) of Tripterygium wilfordii have historically been used…
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Automated Metadata Review to Support Result Release in Quantitative Liquid Chromatography Coupled With Tandem Mass Spectrometry Applications
ABSTRACT Quantitative multi‐target analysis of biological samples using isotope‐dilution liquid chromatography coupled with tandem mass spectrometry (LC‐MS/MS) is widely applied in laboratory diagnostics and life sciences now. These analyses generate a large amount of metadata (e.g. ion ratios…
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Gas Chromatography‐Mass Spectrometry‐Based Phytochemical Profiling and Bioactivity‐Guided Fractionation of Psidium guineense Stem Extracts: In Vitro and In Silico Insights Into Antioxidant, Antidiabetic and Antibacterial Potentials
ABSTRACT Psidium guineense (Myrtaceae) is traditionally used for various medicinal purposes, although its stem remains underexplored. This study provides the first integrated phytochemical, pharmacological and computational evaluation of the stem extracts to elucidate their antioxidant…
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Dry Deposition Strategies for MALDI–MS Imaging: Principles, Advances and Emerging Applications
ABSTRACT Matrix‐assisted laser desorption/ionisation mass spectrometry imaging (MALDI–MSI) has become a pivotal tool in biomedical research, enabling untargeted, spatially resolved analysis of molecular species in complex biological tissues. Among the critical steps in MALDI–MSI workflows, matrix…
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A Robust Cost‐Effective Spectrophotometric Method for Nb Determination in Refractory Nb‐doped Gadolinium Zirconate: Overcoming Matrix Dissolution Challenges
ABSTRACT A simple, robust and cost‐effective analytical methodology was developed for the determination of niobium in highly refractory materials: Nb‐doped gadolinium zirconate (Gd2Zr2O7:Nb) and niobium pentoxide (Nb2O5). The challenge of digesting these matrices was successfully accomplished by…
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Artikel Jurnal
Analysis of Two New Flavonoid Glycosides From Zanha golungensis Hiern With COX Inhibition Activity: Structural Elucidation, DFT Calculations, In Vitro and Molecular Docking Assessment
ABSTRACT Zanha golungensis is used as herbal medicine for a variety of ailments. In this study, flavonoids, including two new kaempferide polyglycosides, namely, kaempferide‐3‐O‐[α‐l‐rhamnopyranosyl‐(1→2)‐α‐l‐rhamnopyranosyl‐(1→6)]‐β‐d‐glucopiranoside‐7‐O‐α‐l‐rhamnopiranoside (1) and…
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Method Development and Validation for the Simultaneous Analysis of Miconazole Nitrate, Hydrocortisone and Chlorocresol in a Pharmaceutical Topical Cream by Reverse Phase Liquid Chromatography
ABSTRACT Miconazole/Hydrocortisone (HCA) cream is a pharmaceutical formulation developed as a combination of three major components (HCA, miconazole nitrate [MCN] and chlorocresol [CHL]). In some instances, reference monographs used for referencing the quantification of pharmaceutical molecules…
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Integrated Orbitrap‐HRMS and Chemometric Profiling Reveals Metabolite Diversity and Antioxidant Signatures in Cerrado Eugenia Fruits
ABSTRACT Fruits from the Brazilian Cerrado, such as pitanga (Eugenia uniflora), jambolao (E. jambolana) and murta (E. punicifolia), are recognized for their nutritional and therapeutic potential, largely due to their phenolic‐rich profiles. However, systematic studies integrating high‐resolution…
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Artikel Jurnal
Extraction of Sulfachloropyridazine from Food Samples Using Cellulose: Application of Central Composite Design Approach
ABSTRACT Sulfonamide antibiotics are among the most widely used veterinary drugs in livestock and often end up contaminating milk, which is subsequently consumed by humans. To mitigate this health hazard, cellulose and its functionalized derivatives were investigated for their ability to extract…
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Artikel Jurnal
A Novel Ultra‐Performance Liquid Chromatography‐Electrospray Ionisation‐Tandem Mass Spectrometry Method for Quantification of Imeglimin in Human Plasma: Application to a Bioequivalence Study
ABSTRACT The pharmaceutical market has recently witnessed the advent of a novel tetrahydrotriazene molecule belonging to the new pharmacological class “Glimins”, named Imeglimin (IMG). It has been approved in Japan as a safe and highly effective oral diabetic drug for type II diabetic patients. It…
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Beyond Beer‐Lambert Linear Regression: Multi‐Layer Modeling for Wide‐Range Concentration Quantification Using Ultraviolet‐visible Spectroscopy
ABSTRACT Ultraviolet–visible (UV‐Vis) spectroscopy is widely used for chemical quantification due to its simplicity and low cost; however, accurate concentration prediction becomes challenging when target concentrations span wide ranges, where the global linearity assumption of the Beer‐Lambert law…
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Rapid Analysis of Sports Prohibited Substances in Black Market Pharmaceutical Products Using Atmospheric Solids Analysis Probe‐Mass Spectrometry
ABSTRACT Misuse of performance‐enhancing substances in sport remains a persistent threat to the values of fair competition, with estimated doping prevalence far exceeding adverse analytical findings in routine testing. This highlights the need for improved surveillance tools capable of rapid and…
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Comprehensive Quantitative Urinary Steroid Profiling of 29 Steroids Using Liquid Chromatography‐Tandem Mass Spectrometry
ABSTRACT Steroids are critical for numerous physiological processes; disruption in their metabolism is associated with numerous endocrine disorders. Steroid quantification is essential to improve the understanding and diagnosis of these pathologies. Historically, urinary steroid profiling has been…
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Artikel Jurnal
Analytical Green Star Area for Sample Preparation (AGSA‐Prep) as a Comprehensive and Practice‐Oriented Metric
ABSTRACT Sample preparation is a critical, yet often environmentally burdensome, step in analytical chemistry. While Green Sample Preparation principles aim to mitigate this impact, existing assessment tools such as AGREEprep offer room for improvement in the assessment process. In particular…
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Artikel Jurnal
A Selective Phenyl Azo Acetate Substrate for Enhanced Carbonic Anhydrase Functional Analysis
ABSTRACT Carbon dioxide (CO2) sequestration is a key strategy for mitigating climate change, and biocatalytic approaches offer sustainable, cost‐effective alternatives to chemical and physical methods. Carbonic anhydrases (CAs) efficiently catalyse the reversible hydration of CO2 to bicarbonate…
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Wooden‐Tip Electrospray Ionization Mass Spectrometry Combined With Machine Learning for Differentiating Thyroid Tumours
ABSTRACT Direct mass spectrometry (MS) analysis of human tissues at the molecular level has great potential for clinical diagnosis and biomarker discovery. However, conventional MS‐based analytical methods often require complicated and time‐consuming sample preparation, which limits their…
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Artikel Jurnal
PANI/PTA/Fe3O4 Nanocomposite Coated on Stainless‐Steel Towards Efficient Solid‐Phase Microextraction of Tetracycline From Human Urine Samples Prior to HPLC–DAD Analysis
ABSTRACT Tetracycline (TC) is a commonly prescribed broad‐spectrum antibiotic, and its widespread use together with its persistence in biological matrices, particularly urine, has raised serious concerns related to clinical safety, public health and the emergence of antimicrobial resistance…
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Metabolomic Differentiation of Malpighiaceae From Dry and Humid Tropics via UHPLC‐MS/MS and Chemometrics
ABSTRACT Various factors can trigger water stress in plants, particularly in those growing in dry tropical regions. To survive under such conditions, plants produce metabolites with adaptive functions. However, metabolomic data on the leaves of Malpighiaceae species cultivated in both dry and humid…
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Artikel Jurnal
Method Comparison of Dried Blood Spot and Plasma Apolipoprotein B Measurement on a Semi‐Automated Analyser: Toward Accessible Lipid Profiling in Resource‐Limited Settings
ABSTRACT Apolipoprotein B (ApoB) is a key marker of atherogenic lipoprotein burden, but conventional plasma‐based testing requires venous sampling and centralized laboratory infrastructure. Dried blood spot (DBS) sampling offers a minimally invasive alternative suitable for decentralized settings…
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Artikel Jurnal
Lipopolysaccharide‐Specific Aptasensor: A Spectroscopic Approach for Identifying Gram‐Negative Bacteria
ABSTRACT Differentiating bacteria into Gram‐negative and Gram‐positive categories is a standard method of identification in biological science and is essential for understanding bacterial characteristics. This study presents a novel aptasensor that integrates an anti‐lipopolysaccharide (LPS)…