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BMJ Neurology Open
Scopus
ISSN 2632-6140 · BMJ Publishing Group · 795 articles in the index
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Journal Article
18F-DPA-714 PET/MRI reveals early and widespread neuroinflammation in sporadic Creutzfeldt–Jakob disease: a case report
Background Creutzfeldt–Jakob disease (CJD) is a fatal neurodegenerative disorder caused by prion proteins, with microglial activation being a key immunopathological feature. This case report demonstrates the application of 18F-DPA-714 positron emission tomography (PET)/MRI, a second-generation…
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Journal Article
Non-invasive electrodiagnostic testing for small fibre neuropathy in long COVID-19
Background Long COVID-19 is associated with a diverse range of debilitating neuropathic and autonomic symptoms that may indicate small fibre neuropathy (SFN). We aimed to assess the utility of multimodal non-invasive electrodiagnostic techniques in evaluating symptomatic individuals.Methods People…
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Journal Article
Understanding dopaminergic dose reduction following STN-DBS: mediation analysis
Background Levodopa equivalent dopaminergic dose (LEDD) reduction after subthalamic nucleus deep brain stimulation (STN-DBS) in Parkinson’s disease varies widely. Identifying predictors may guide patient selection and programming. Our objectives were to identify predictors of LEDD reduction and to…
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Journal Article
Deep brain stimulation for Parkinson’s disease in Thailand: cost, utility and policy implications for universal health coverage
Background Parkinson’s disease (PD) is a chronic, progressive, disabling neurodegenerative disorder. Deep brain stimulation (DBS) surgery is a highly effective and beneficial therapy for advanced PD, but its substantial cost limits accessibility. This study aimed to evaluate the cost–utility and…
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Journal Article
New-onset refractory status epilepticus associated with Sjögren’s disease
Sjögren’s disease (SjD) is a chronic autoimmune connective tissue disorder primarily affecting the salivary and lacrimal glands. Extra-glandular involvement may occur, sometimes preceding the diagnosis of SjD or in the absence of sicca symptoms, contributing to diagnostic delay. Central nervous…
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Journal Article
Exploring cardiac autonomic dysfunction in synucleinopathies with parkinsonism through awake–sleep stages: a possible connection to cardiovascular death
Introduction Alpha-synucleinopathies (ASs), including Parkinson’s disease, multiple system atrophy and dementia with Lewy bodies, are characterised by autonomic dysfunction that may predispose to cardiovascular events and sudden death. Heart rate variability (HRV) is a non-invasive marker of…
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Journal Article
Clinical profile and treatment outcomes of patients with chronic presentations of autoimmune encephalitis: expanding the spectrum
Background The spectrum of autoimmune encephalitis (AIE) is evolving due to heterogeneity of clinical syndromes associated with autoantibodies. While majority of patients present within 3 months, little is known about chronic presentations of AIE. This study aims to characterise the…
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Journal Article
Guide to developing research recruitment strategies with the experts
Background The aim of this project was to work in partnership with people living with neurological diseases, from backgrounds that are racially minoritised in the UK, to co-produce a research recruitment strategy. Their experiences living with a neurological disease were vital to the co-production…
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Journal Article
Poststroke fatigue in subacute and chronic stroke rehabilitation phase: prevalence, associated factors and impact on self-efficacy and functional ability
Background Stroke is a leading cause of death and long-term disability worldwide, with low-income and middle-income countries accounting for about 87% of stroke-related deaths and disability-adjusted life-years. Among poststroke complications, poststroke fatigue is a common but often…
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Journal Article
Low risk of severe COVID-19 in vaccinated people with multiple sclerosis: a nationwide Norwegian study
Background We aimed to assess antibody responses and COVID-19 outcomes after vaccination in people with multiple sclerosis (pwMS) receiving disease-modifying therapies.Methods NevroVAX is a Norwegian multicentre cohort study including 3559 pwMS and 449 healthy controls (HCs) who received at least…
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Journal Article
United Kingdom Young Stroke Study (UKYSS): study protocol for an ambispective observational study
Introduction 10%–15% of strokes occur between 18 and 50 years old. Young stroke incidence in the UK is increasing with high risk factor burden and varied aetiology. Long-term functional and psychological sequelae are highly prevalent. This study will provide representative information on UK young…
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Journal Article
Reduced intracortical inhibition and enhanced intracortical facilitation in patients with functional tremor
Background The pathophysiological mechanism underlying functional tremor (FT) has not been elucidated. Transcranial magnetic stimulation (TMS) is a non-invasive tool to explore cortical excitability in various neurological and neuropsychiatric disorders. The aim of this study is to evaluate the…
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Journal Article
Bi-allelic intermediate ATXN2 repeat expansions are associated with slow progressing, leg-onset familial ALS
Objectives The identification of bi-allelic intermediate ATXN2 repeat expansions in a pedigree with amyotrophic lateral sclerosis (ALS) through clinical testing prompted us to investigate its relevance in the wider ALS population.Methods ATXN2 repeat size was assessed in a large international…
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Journal Article
Impact of whole-body vibration training on gait in patients with progressive multiple sclerosis: a pilot randomised study
Background Oscillatory whole-body vibration (WBV) training improves strength and movement skills in healthy adults and individuals with various medical conditions. Studies examining the effects of WBV on gait disorder in people with multiple sclerosis (PwMS) of progressive disease form (progressive…
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Journal Article
Predicting cancer aetiology in patients with stroke using brain imaging alone
Background Ischaemic stroke due to cancer is becoming more common with high mortality rate. There is an unmet need to predict cancer aetiology in patients with stroke using brain imaging alone, to facilitate early diagnosis and treatment.Aims To describe unique brain imaging patterns of…
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Journal Article
Perinatal, neurodevelopmental and childhood health factors in patients with functional neurological disorder: a retrospective case-record study in a tertiary neuropsychiatry cohort
Background Functional neurological disorder (FND) is a complex neuropsychiatric condition. While psychological factors have been widely studied, less is known about the role of perinatal, neurodevelopmental and childhood/adolescent physical health factors.Objective This retrospective case record…
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Journal Article
Mapping end-of-life care for patients with neurological conditions in German hospices: a point prevalence survey
Background Access to palliative care for patients with neurological diseases remains limited. Contributing factors include difficulties in predicting disease trajectories, resource constraints in long-term care and challenges in identifying the end-of-life phase—often compounded by communication…
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Journal Article
Neurophobia among the Egyptian early-career physicians: the first national multi-centre report
Background There is a shortage of neurologists at a time when brain disorders have become major contributors to disability and death worldwide. This is the first national study of Egyptian early-career physicians, exploring their attitudes towards neurology and neuroscience.Methods This…