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Neuroscience Insights
Scopus
ISSN 2633-1055 · SAGE Publishing · 180 artikel di indeks
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Artikel Jurnal
Neurocognitive Mechanism of Perceptual Errors in Radiologists: Results of Pilot Studies
Background The most prevalent type of radiologist error is failing to detect abnormalities on images, the so-called “perceptual error.” The prevalence of this type of false-negative (FN) error remains essentially unchanged since it was first described in 1949. Reducing this error rate would be…
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Artikel Jurnal
4-(Phenylsulfanyl) Butan-2-One Reduces Mechanical Hypersensitivity in an STZ-Induced Rat Model of Diabetic Neuropathy via TGF-β Associated Suppression of Spinal Neuroinflammation
Diabetic neuropathy is a common complication of diabetes and is associated with persistent spinal neuroinflammation, glial activation, and maladaptive intracellular signaling that contribute to pain-like behaviour. This study investigated the antinociceptive efficacy and associated spinal…
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Neuromodulation of Working Memory: Mechanisms, Targets, and Behavioral Outcomes
Working memory (WM) is a capacity-limited control system that maintains and updates task-relevant representations for goal-directed cognition. Because WM declines with aging and is disrupted across neuropsychiatric and neurodegenerative disorders, neuromodulation has emerged as both a causal probe…
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Neuronal Regulation and Locomotion in Rats Following Spinal Cord Injury: Reconciling Behavioral Scales With Neuroelectrophysiology
Progress in translating spinal cord injury (SCI) therapies from bench to bedside remains bottlenecked by a critical paradox in preclinical phenotyping: the frequent divergence between behavioral recovery metrics and objective neurophysiological outcomes. For decades, the Basso, Beattie, and…
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Neuroscience Insights: Publishing Rigorous Work Through Fair Review Process
This editorial marks the beginning of my tenure as Editor-in-Chief of Neuroscience Insights . The journal’s founding aims of publishing rigorous, mechanistically grounded research spanning the nervous system from molecule to behavior remain unchanged. But as the incoming Editor-in-Chief, I am…
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Activity and State-Dependent Modulation of Salt Taste Behavior Via Pharyngeal Neurons in
Sodium, which is present in NaCl (Sodium Chloride), is a vital nutrient required for numerous physiological processes. In animals, including Drosophila , low-salt concentrations induce attraction and high-salt concentrations trigger aversive behavior. Although the analysis of low and high salt…
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Effects of Sex, Estradiol, and Acute Stress on Spontaneous Recovery of a Conditioned Touchscreen Response in Rats
The present study examined sex differences and the effects of estradiol on acquisition and extinction using an appetitive reinforcement schedule in operant touchscreen chambers. Additionally, it aimed to clarify how acute stress influences response inhibition, as assessed by the spontaneous…
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Mature Schwann Cells Derived From Human Induced Pluripotent Stem Cells Promote Peripheral Nerve Regeneration In Vivo
Peripheral nerve injuries (PNIs) often cause persistent sensory and motor deficits that impair quality of life. To improve outcomes, cell-based therapies have been explored, and Schwann cells (SCs) are considered a promising option because of their essential roles in myelination and neurotrophic…
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Artikel Jurnal
Pulsatility index: Insights into post-stroke haemodynamics
Acute ischaemic stroke is a leading cause of acquired disability globally, with millions of patients afflicted each year. Fast and efficient recanalization therapies have revolutionized long-term patient outcomes. However, a substantial fraction of patients does not regain complete functional…
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Synaptic Chaperone Dysfunction as a Convergent Mechanism in Neurodegenerative and Psychiatric Disorders
The heat shock protein (HSP) family comprises six sub-families whose members participate in a wide array of cellular processes. This minireview focuses on three specific heat shock proteins: Hsp90aa and Hsp90ab from the Hsp90 sub-family, Hsc70 (Hspa8) from the Hsp70 sub-family, and the Hsp40…
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Artikel Jurnal
Stage-Dependent Function of Astrocytes in Alzheimer’s Disease: A Review
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder marked by extracellular amyloid beta (Aβ) plaques, intracellular neurofibrillary tangles (NFTs), astrogliosis, loss of neurons, and cognitive decline. In this narrative review, we explore astrocytes’ dual role in the healthy brain…
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Re-Examination and Extension of Manual Dexterity Behavioral Data in M1 Lesioned Adult Macaque Monkeys: A Survey of Therapies Induced Enhancement of Functional Recovery
The present report offers a survey, with re-examination and extension of data, of previously published intermediate papers on the functional recovery of manual dexterity in non-human primates following primary motor cortex (M1) lesion, either spontaneous or enhanced with 2 distinct therapies. For…
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The Geometric Signatures of Brain State Transitions: Recursive Informational Curvature Reveals Hidden Dynamics in Primate Cortex
Objective: Recursive Informational Curvature (RIC) was recently introduced as an information-geometric framework for describing the balance between recursive structure and entropy change in dynamical systems. Here, we present the first empirical implementation and benchmark evaluation of its scalar…
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The CHD Protein, Kismet, Restricts Synaptic BMP Signaling at Glutamatergic Synapses
CHD7 and CHD8 are chromatin remodeling proteins that regulate several neurodevelopmental events. Mutations in these chromatin remodeling genes occur in neurodevelopmental disorders including CHARGE Syndrome and Autism Spectrum Disorders. Kismet (Kis) is the sole Drosophila homolog of CHD7 and CHD8…
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Artikel Jurnal
Comprehensive Proteomic Profiling of Human Nav1.7-Interacting Proteins Reveals Conserved Regulatory Networks Involved in Nociceptive Signaling
The voltage-gated sodium channel Nav1.7, encoded by the SCN9A gene, is critically involved in the initiation and propagation of nociceptive signals. While prior research has delineated the interactome of mouse Nav1.7 (mNav1.7), the molecular partners associated with its human homolog (hNav1.7)…
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Artikel Jurnal
Sciatic Nerve Electrical Stimulation Enhances Locomotor Recovery in Rats Following Spinal Cord Contusion
Spinal cord injury affects over 300 000 individuals in the United States with limited treatment options for significant locomotor functional recovery. While functional electrical stimulation devices to assist reciprocal muscle contraction during movement are used in rehabilitation, their efficacy…
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Artikel Jurnal
Investigating Prospective Memory Processes: ERP Evidence from Novel Semantic Judgment Tasks
Prospective memory (PM), the ability to plan and execute intentions in the future, plays a critical role in managing everyday tasks. A gap exists in our understanding of the neural mechanisms underlying PM retrieval based on semantic judgment, particularly when using picture-based stimuli. The…
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Traumatic Brain Injury and Alzheimer’s Disease: A Shared Neurovascular Hypothesis
Traumatic brain injury (TBI) is a modifiable risk factor for Alzheimer’s disease (AD). TBI and AD share several histopathological hallmarks: namely, beta-amyloid aggregation, tau hyperphosphorylation, and plasma protein infiltration. The relative contributions of these proteinopathies and their…
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The Flipons, Infections, and Amyloids that Foreshadow the Fading Memories of Alzheimer’s Disease
Our memories are almost magical. We can experience an event for a short moment in time and quickly recall it decades later. This review explores the impact of some relatively new discoveries in the field of flipon biology that provide insight into diseases associated with impaired memory function…
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Artikel Jurnal
Long-term Neurological Consequences of COVID-19 in Patients With Pre-existing Alzheimer’s and Parkinson’s Disease: A Comprehensive Review
SARS-CoV-2, the causative agent of COVID-19, has profound systemic effects, including significant impacts on the central nervous system (CNS). Emerging evidence suggests a potential link between SARS-CoV-2-induced neuroinflammation and the exacerbation or initiation of neurodegenerative diseases…