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Advances in Pharmacological and Pharmaceutical Sciences
Scopus
ISSN 2633-4690 · Wiley · 339 artikel di indeks
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Artikel Jurnal
Dicaffeoylquinic Acid–Rich Sunflower Sprout Extract Attenuates High-Fat Diet-Induced Obesity in Rats
Obesity is a major hallmark of metabolic syndrome and is strongly associated with an increased risk of cardiovascular disease progression. Sunflower sprouts are a particularly rich source of caffeoylquinic acids (CQAs), compounds recognized for their capacity to attenuate weight gain and mitigate…
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Artikel Jurnal
Neuroprotective Effects of Huperzine B and Huperzia carinata Extract Against MPP+-Induced Oxidative Stress in SH-SY5Y Cells
Parkinson’s disease (PD) is a neurodegenerative disorder associated with dopaminergic neuronal loss, mitochondrial dysfunction, and redox imbalance. Huperzine B (HupB), an alkaloid derived from Huperzia species, has demonstrated antioxidant and acetylcholinesterase-inhibitory activity; however, its…
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Artikel Jurnal
Effects of Sesamum indicum L. Seed Extract on Male Reproductive Parameters and In Silico Anti-Infertility Insights
The etiological contribution of male factors to infertility remains a significant concern in reproductive health. Natural dietary products are gaining attention as promising interventions to improve male infertility. This study investigates the effects of aqueous extract of Sesamum indicum L. (S…
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Artikel Jurnal
Mechanistic Insights Into House Dust Mites Immunotherapy-Induced Desensitization for Sustained Protection of Allergic Rhinitis in Mice
The worldwide prevalence of allergic rhinitis (AR) is substantial and is considered a global health problem. Allergen immunotherapy (AIT) is the only approach that treats the underlying cause of allergy by inducing a desensitization response to the allergen. In this study, we investigated the…
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Artikel Jurnal
Nrf2/GPX4-Dependent Ferroptosis Inhibition: The Central Mechanism Underpinning Germacrone-Induced Cardioprotection in Myocardial Infarction
Myocardial infarction (MI) involves a pathological process in which its association with ferroptosis is notably pronounced, and targeted regulation of ferroptosis presents a promising approach for treating MI. This work delineates the molecular basis by which the natural sesquiterpene germacrone…
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Artikel Jurnal
Long-Term Risk of Type 2 Diabetes Associated With Topical Corticosteroid Use: A Nationwide Population-Based Cohort Study in Korea
Steroid-induced diabetes mellitus (SIDM) is a well-known side effect of corticosteroid agents. While diabetes induced by systemic corticosteroids has been extensively studied for over 60 years, evidence regarding the association between topical corticosteroids and Type 2 diabetes remains limited…
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Artikel Jurnal
PCSK9-Mediated Inflammation in Foam Cell Formation and Exploring the Biologically Active Compounds Derived From Natural Resources
Atherosclerosis develops as a persistent inflammatory condition that gradually alters the vascular structure and condition, in which the formation of macrophage-derived foam cells plays a central role in disease initiation and progression. Although proprotein convertase subtilisin/kexin type 9…
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Artikel Jurnal
The Leaf Aqueous and Ethanolic Extracts of Tricalysia okelensis Hiern. (Rubiaceae) Reverse L-NAME-Induced Hypertension, Cardiac, and Vascular Remodeling in Rats
Arterial hypertension is a worldwide challenging medical condition that continues to raise havoc despite existing treatments, prompting the need to develop new medicine. In a pilot study, we demonstrated that Tricalysia okelensis exhibits a vasorelaxant effect. This study evaluates the…
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Artikel Jurnal
Bazedoxifene and Beyond: Identifying This SERM’s Targets and Deciphering Its Molecular Mechanisms
Bazedoxifene (BZA), a third-generation selective estrogen receptor modulator (SERM) approved for osteoporosis treatment, is attracting attention for drug repurposing, especially in cancer research. While designed primarily for estrogen receptors, BZA exhibits in vitro off-target interactions that…
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Artikel Jurnal
The Ethanol-Insoluble Low-Molecular-Weight Fraction LEP-4 Derived From Lentinula edodes Mycelia Extract Attenuates Oxaliplatin-Evoked Allodynia in Mice
Chemotherapy-induced peripheral neuropathy (CIPN) is an adverse event caused by drugs such as bortezomib, vincristine, paclitaxel, and oxaliplatin (L-OHP). This condition can lead to the discontinuation of anticancer drug administration and a diminished quality of life, posing a significant…
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Artikel Jurnal
Annona muricata Polyphenols Induce Cytoskeletal Alterations and Predicted Aldose Reductase Binding in Giardia lamblia
In this study, we evaluated the in vitro and in silico effects of a polyphenol-enriched extract from Annona muricata (soursop) leaves against G. lamblia trophozoites. The extract had a noticeable impact on parasite growth, cell adhesion, and morphology. Ultrastructural analyses revealed elongation…
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Artikel Jurnal
Fingerroot Extract Oral Spray for Anticariogenic Purpose: Integration of Ultrasound-Assisted Extraction and Solvent System Optimization
Fingerroot (Boesenbergia rotunda (L.) Mansf.), a member of the Zingiberaceae family, exhibits anticariogenic activity against Streptococcus mutans. This study aimed to optimize ultrasound-assisted extraction and solvent system selection for oral spray development. Extraction conditions were…
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Artikel Jurnal
Protective Role of Linagliptin in Cisplatin-Mediated Liver Injury: Involvement of STAT3 and AMPK/SIRT1/PGC-1alpha Mitochondrial Energy Sensing Networks
Cisplatin (Cis), a commonly used chemotherapy drug, is associated with liver toxicity, which restricts its broader clinical use. This study investigated the potential protective effects of linagliptin (Lina), a DPP-4 inhibitor, in preventing liver damage induced by Cis in rats. There were four…