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Endocrine Oncology
Scopus
ISSN 2634-4793 · Bioscientifica · 146 artikel di indeks
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Artikel Jurnal
Patient-reported symptom and urgent healthcare use in neuroendocrine tumors
Background: Patients with neuroendocrine tumors (NETs) have a high burden of symptoms persisting over years after diagnosis. Patient-reported outcome measures are routinely screened for in oncology practice but seldom used for interventions. Further information about how they are linked to outcomes…
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Artikel Jurnal
To screen or not to screen: complexity of SDHA mutation management
Pathogenic germline variants in the genes encoding the various subunits of the succinate dehydrogenase (SDH) enzyme complex are strongly associated with hereditary phaeochromocytomas and paragangliomas (PPGLs). Germline pathogenic variants (PGVs) in the SDHA gene are also found in individuals with…
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Artikel Jurnal
MRI and 18F-fluorothymidine PET-MR for the early evaluation of renal and bone marrow effects in 177Lu-DOTATATE therapy
Background: This study aimed to evaluate whether early renal and bone marrow effects – previously identified through laboratory tests – can be detected using MRI and 18F-FLT PET-MR in neuroendocrine tumor patients treated with 177Lu-DOTATATE. Despite known early changes, precise clinical tools to…
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Artikel Jurnal
Physical activity and systemic treatment outcomes in advanced thyroid cancer
Introduction: Physical activity interventions could play a critical role in tolerance and outcome during anti-neoplastic therapy. Aim: This study aims to evaluate the role of physical activity and its maintenance on treatment safety and efficacy in patients with advanced thyroid cancer. Methods: We…
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Artikel Jurnal
Primary tumor size as a prognostic factor in duodenal neuroendocrine neoplasms ≤20 mm: a population-based SEER analysis
Objective: The prognostic value of primary tumor size in duodenal neuroendocrine neoplasms (dNENs) ≤20 mm remains uncertain. Although size is used to guide management, its independent effect on survival is unclear. Design and methods: We performed a population-based study using the US SEER database…
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Artikel Jurnal
Multimodal management of hormonal and oncological progression in PTHrP-secreting pancreatic neuroendocrine tumours
Parathyroid hormone-related peptide (PTHrP)-secreting pancreatic neuroendocrine tumours (Pan-NETs) are a rare cause of humoural hypercalcaemia of malignancy (HCM). We report two contrasting cases of metastatic well-differentiated PTHrP-secreting Pan-NETs (WHO grade 2; Ki-67: 7 and 8%…
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Artikel Jurnal
Functional and behavioral outcomes in pediatric adrenal carcinoma under mitotane therapy: a caregiver-reported pilot study
Objective: Mitotane is the standard therapy for advanced pediatric adrenocortical carcinoma (pACC). With improving survival, treatment-related long-term side effects and their impact on everyday functioning are becoming increasingly relevant. This multicenter pilot study provides first insights…
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Artikel Jurnal
Metastatic neuroendocrine lesions in diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH): a narrative review and case series
Objective: Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH) is a rare entity characterised by the proliferation of neuroendocrine cells in the respiratory epithelium. DIPNECH is a pre-neoplastic condition that can progress to localised or metastatic neuroendocrine tumours…
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Artikel Jurnal
Pathogenic germline variants identified in pNEN patients during genetic testing
Poor outcomes in pancreatic neuroendocrine neoplasms (pNENs) partially result from the inability to identify early-stage disease in patients. Prevention strategies have focused on identifying high-risk patients through genetic susceptibility genes. This study aims to report the incidence of…
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Artikel Jurnal
Hematological neoplasms after PRRT: experience from long term follow-up of 173 patients in a tertiary center
Objective: Peptide receptor radionuclide therapy (PRRT) with lutetium-177 DOTATATE (177Lu-DOTATATE) is widely adopted as a later-line treatment (second-line or subsequent therapy) for patients with somatostatin receptor-positive neuroendocrine neoplasm. The registration NETTER-1 trial reported a…
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Artikel Jurnal
SDHB and CDK1 protein expression in metastatic pheochromocytoma and paraganglioma
Background: Pheochromocytomas and paragangliomas (PPGLs) are rare and mostly non-metastatic tumors originating from adrenal medulla and paraganglia. Metastatic PGLs have a worse prognosis, but currently, there are no established criteria to determine PPGL metastatic potential. Aim: The aim of this…
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Artikel Jurnal
Parathyroid carcinoma: epidemiology and genetics
Primary hyperparathyroidism (PHPT), considered a rare disease almost a century ago, has shown a notable increase in incidence over the past five decades, driven largely by improved diagnostic screening and greater clinical awareness. Following the same trend, the incidence of parathyroid carcinoma…
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Artikel Jurnal
CHEK2 germline gene variant in a patient with a somatotrophinoma and primary hyperparathyroidism: a novel MEN1-like syndrome?
Context: Somatotrophinomas can occasionally occur in familial settings and may be associated with known germline mutations, such as MEN1, AIP, CDKN1B, PRKAR1A, SDHx, and MAX. Recently, the CHEK2 gene has emerged as a potential pituitary tumour predisposition gene. Objective: To present a rare case…
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Artikel Jurnal
Metformin modifies hormone changes associated with androgen deprivation therapy for prostate cancer
Androgen deprivation therapy (ADT) is regularly used to treat locally advanced and metastatic prostate cancer (PCa) with toxicities, including metabolic syndrome (MS) and associated adverse hormonal changes. This study evaluated whether metformin mitigates changes in laboratory biomarkers…
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Artikel Jurnal
A contemporary overview of multiple endocrine neoplasia syndromes: MEN syndromes 1–5 and beyond
Multiple endocrine neoplasia (MEN) syndromes constitute a heterogeneous group of hereditary disorders predisposing to endocrine tumours of varying malignant potential. Recent advances in molecular genetics and tumour biology have significantly reshaped our understanding of underlying…
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Artikel Jurnal
Mesenteric paraganglioma mimicking nodal metastasis of an occult small intestinal neuroendocrine tumor
Paragangliomas (PGLs) are rare neuroendocrine neoplasms of neural-crest origin, with primary mesenteric localization representing an exceptionally uncommon entity that is rarely considered in the preoperative differential diagnosis of mesenteric masses. We report the case of a 51-year-old woman who…
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Artikel Jurnal
The clinical impact of androgens in endometrial cancer: cancer promoter or suppressor?
Purpose: Androgens are associated with the risk of endometrial carcinoma (EC). However, their roles as prognostic factors are less clear. This study aims to investigate the prognostic impact of different androgens. Methods: We conducted a retrospective cohort study of patients who had previous…
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Artikel Jurnal
Vitamin D receptor expression in germinal centre type diffuse large B-cell lymphoma cells is associated with vitamin D insensitivity
Objective: Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous group of non-Hodgkin lymphomas (NHLs) often sub-classified into major germinal centre (GC) and activated B-cell (ABC) cell-of-origin types. We have previously shown vitamin D receptor (VDR) expression in plasmablastic ABC-DLBCL…
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Artikel Jurnal
Therapy-related myeloid neoplasms following peptide receptor radionuclide therapy for neuroendocrine neoplasms: case series reporting characteristics and outcomes from single-centre experience
Objective: Peptide receptor radionuclide therapy (PRRT) with [177Lu]Lu-DOTATATE is increasingly used in the treatment of metastatic neuroendocrine neoplasms (NENs). Marrow toxicity resulting in therapy-related myeloid neoplasms (t-MNs) remains a rare but fatal complication of PRRT, with a limited…