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Advanced Genetics
ISSN 2641-6573 · Wiley · 111 artikel di indeks
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Artikel Jurnal
From Genes to Ecosystems: Marc Van Montagu on Science, Society, and the Future of Life
Abstract Editor's Note: As part of the Advanced Dialogues series, the editor invites leading scientists and emerging voices to share their research journeys, experiences, and visions for the future of their fields. In this feature, Marc Van Montagu—Emeritus Professor at Ghent University, a founding…
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Artikel Jurnal
Mapping Meiotic Recombination DNA Double‐Strand Breaks (DSBs) Hotspots —Methodological Advances and Challenges
ABSTRACT Programmed DNA double‐strand breaks (DSBs) initiate meiotic recombination at discrete genomic hotspots, and their precise mapping is crucial for understanding the molecular regulation of genome stability and evolution. A variety of genome‐wide methods have been developed, each leveraging…
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Artikel Jurnal
From Cluster to Claim: Calibrating Interpretation in Single‐Cell Transcriptomics
ABSTRACT The widespread adoption of single‐cell transcriptomics has expanded our ability to study cellular heterogeneity and molecular states. However, the high‐resolution view it provides can also make it easier for descriptive data patterns to be translated into biological claims that go beyond…
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Artikel Jurnal
The Rise of Plant Pan‐Genomes: From Genome Variation to Predictive Breeding
ABSTRACT Plant pan‐genomics is entering a new phase beyond genome variation discovery, requiring a shift from cataloguing genomic diversity toward understanding how variation generates biological function and breeding value. Here, we propose that the future of plant pan‐genomics will be shaped by…
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Artikel Jurnal
Foundation Models for Microbiome Research: From Sequence Semantics to Community Dynamics and Multimodal World Models
ABSTRACT Microbiome sequencing has advanced faster than microbiome understanding. Although large‐scale 16S, metagenomic, metatranscriptomic, and proteomic datasets have accumulated rapidly, most analyses remain cohort‐specific and association‐driven, limiting mechanistic insight, cross‐study…
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Artikel Jurnal
Genetic Bone Diseases: A Scoping Review of Pathology, Symptoms, Diagnosis, Treatment, and New Horizons
ABSTRACT Genetic bone diseases are a rare group of afflictions suffered by the general population. However, their rarity should not diminish research efforts to help patients understand and treat their diseases. This review summarizes the pathology, symptoms, diagnosis, and treatment insight into…
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Artikel Jurnal
Biomaterial Physical Cues as Gene Regulators for Cellular Agriculture
ABSTRACT Cultured meat relies on biomaterial scaffolds that not only sustain cell proliferation but also regulate lineage commitment and tissue maturation. Increasing evidence shows that the biophysical properties of biomaterials—such as stiffness, incorporated force fields, wettability, surface…
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Artikel Jurnal
Light‐Activated Nucleic Acid Amplification Systems Using Photo‐Caged DNA Polymerase or Primers
ABSTRACT Precise control over nucleic acid amplification is essential for achieving reliable, quantitative, high‐throughput, and multiplexed molecular diagnostics, particularly in point‐of‐care and field settings. However, conventional isothermal amplification methods, especially rapid assays at…
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Artikel Jurnal
Compact Cas12 Systems for Multiplex Engineering of Plant Abiotic‐Stress Networks
ABSTRACT Compact CRISPR‐Cas12 platforms, particularly miniature and hypercompact effectors such as Cas12f, Cas12j/CasPhi, and Cas12lambda, are emerging as delivery‐efficient tools for plant genome engineering because their reduced coding size facilitates viral‐replicon and other size‐constrained…
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Artikel Jurnal
Locus‐Specific Genetic Associations at the DAOA Gene in Schizophrenia and Bipolar Disorder
ABSTRACT DAOA gene has been implicated in both schizophrenia (SZ) and bipolar disorder (BD), where genetic variants were associated with each disorder individually. However, the common variants shared between SZ and BD within this gene remain underexplored. The current study investigates…
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Artikel Jurnal
PDMSA: A Web‐Based Tool for Pan‐Cancer Survival Analysis Using DNA Methylation Levels as Biomarkers
ABSTRACT DNA methylation levels are intimately associated with tumor development, progression, and therapeutic outcomes. Accurate analysis of the relationship between DNA methylation levels and tumor prognosis facilitates comprehensive investigation of tumor development mechanisms, enabling…
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Artikel Jurnal
Recognition, Signal Transduction, and Amplification of Nucleic Acids Under Isothermal Condition
ABSTRACT Isothermal nucleic acid detection has become a compelling alternative to PCR, enabling rapid analysis with minimal instrumentation and strong potential for point‐of‐care use. Central to assay performance are three interconnected processes: recognition, signal transduction, and…
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Artikel Jurnal
From Disease‐Specific Models to Broad Clinical Utility: A Perspective on AI Hybrid Ensemble Frameworks
ABSTRACT Artificial intelligence (AI) has advanced predictive modeling in medicine, yet many models remain disease‐specific and difficult to generalize across clinical settings. Key challenges include the trade‐off between interpretability and accuracy, reliance on single algorithms, limited…
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Artikel Jurnal
Antioxidation is a Common Defense Strategy for Different Species Under Mechanical Stress
ABSTRACT Mechanical stress, a ubiquitous physical stimulus, triggers oxidative stress through mechanotransduction in diverse organisms, driving the evolution of antioxidant defense systems. This perspective deciphers the molecular evolutionary principles governing these antioxidant strategies…
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Artikel Jurnal
RNAi‐Based Pesticides: Genetic Innovations for Sustainable Crop Protection and One Health
ABSTRACT Conventional chemical pesticides have long protected global crop yields, but their environmental and health impacts, including contamination, biodiversity loss, residue accumulation, and pest resistance, demand sustainable alternatives. RNA interference (RNAi) represents a genetic…
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Artikel Jurnal
Evolution of H5N1 Cross‐Species Transmission: Adaptive Mutations Driving Avian‐to‐Human Infection
ABSTRACT First detected in poultry in China in 1996, the H5N1 avian influenza virus has evolved into a significant global public health hazard, primarily owing to its high pathogenicity and potential for interspecies transmission. While primarily affecting avian species, H5N1 has repeatedly…
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Artikel Jurnal
Best Practices for Developing Linear Models With Multiple Explanatory Variables
ABSTRACT Linear models, including t‐test, ANOVA, regression, ANCOVA, and generalized linear models, are foundational tools in statistical analysis. For large datasets, such as those involving tens of thousands of genes and millions of records, numerous advanced methods have been developed to…
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Artikel Jurnal
Ciliary Defects in Inherited Retinal Diseases
ABSTRACT Inherited retinal diseases (IRDs) are a heterogeneous group of disorders characterized by progressive photoreceptor degeneration that frequently results in severe vision loss. A major cause of IRDs is attributed to structural or functional defects of the photoreceptor cilium that arise…
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Artikel Jurnal
Brachydactyly with Novel BMP8A and FGFR1 Variants: A Case Report with Review of Literature
Abstract Bone morphogenetic proteins (BMPs) and the fibroblast growth factor receptor 1 (FGFR1) gene play essential roles in the development and maintenance of the skeletal system. Brachydactyly is a genetic condition characterized by shortened or missing bones in the hands and feet. Several types…
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Artikel Jurnal
3D Genome Architecture in Stem Cell Lineage Commitment: from Structural Organization to Precision Regulation
Abstract Stem cell lineage commitment is governed by intricate interactions between epigenetic mechanisms and 3D genome organization. Traditional linear epigenetics, including DNA methylation and histone modifications, cannot fully elucidate the complex spatiotemporal regulation of gene expression…