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Molecular Biomedicine
Scopus
ISSN 2662-8651 · Springer · 570 artikel di indeks
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Artikel Jurnal
CAR-engineered cell therapies: current understandings and future perspectives
Abstract Chimeric antigen receptor (CAR)–engineered cell therapies represent a significant breakthrough in immunotherapy, initially in cancer and now expanding into diverse clinical fields. While originally developed for oncology, these platforms are increasingly being adapted for non-malignant…
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Artikel Jurnal
TBC1 domain family member 23 is essential for STING-mediated anti-melanoma effect
Abstract The innate immune cyclic GMP–AMP synthase–stimulator of interferon genes (cGAS–STING) pathway plays a central role in antitumor immune responses. Cytosolic DNA recognition by cGAS leads to cGAMP production, activating STING and downstream effectors TANK-binding kinase 1 (TBK1) and…
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Artikel Jurnal
Lactate metabolism and protein lactylation in cancer
Abstract Lactylation is a recently identified post-translational modification that links cellular metabolism to gene regulation, playing pivotal roles in cancer development and the tumor microenvironment (TME). Derived from lactate produced by glycolysis and glutamine metabolism, lactylation occurs…
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Artikel Jurnal
Structurally-optimised HPV16 E7/E6 mRNA–LPP mediates dose-sparing efficacy via tumour microenvironment reprogramming
Abstract The development of therapeutic vaccines against human papillomavirus (HPV)–associated malignancies remains challenging due to the immunosuppressive tumour microenvironment and the limited efficacy of existing delivery platforms. In this study, we designed and systematically compared two…
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Artikel Jurnal
Combination of adenovirus vector and subunit protein elicits a robust immune response against the SARS-CoV-2 Omicron variant
Abstract The rapid and ongoing emergence of SARS-CoV-2 variants has progressively reduced the protection offered by current vaccines, underscoring the urgent need for novel vaccine strategies. In this study, we designed a two-component vaccine in which one component is an adenoviral vector encoding…
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Artikel Jurnal
miR-338-3p promotes radiation recall like dermatitis by suppressing pleiotrophin via the PI3K/Akt/Bcl2 pathway
Abstract Radiation recall dermatitis (RRD) is a rare but severe inflammatory reaction induced by certain drugs in previously irradiated skin, which can markedly impair quality of life and disrupt cancer treatment. However, the molecular mechanisms underlying RRD remain poorly understood. In this…
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Artikel Jurnal
Role of autophagy in tumorigenesis and drug resistance: molecular mechanisms and therapeutic targets
Abstract Autophagy represents a conserved lysosome-dependent catabolic mechanism that safeguards cellular energetic homeostasis and supports adaptive metabolic remodeling under diverse stress conditions. In cancer, autophagy displays a highly context-dependent “double-edged sword” behavior. During…
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Artikel Jurnal
Colorectal cancer pathogenesis, oncogenic signaling networks and targeted therapeutic advances
Abstract Colorectal cancer (CRC) constitutes a prominent global health burden, being the third most frequently diagnosed malignancy in terms of incidence and the second leading cause of cancer-associated death across the globe. Malignant transformation of colonic epithelial cells stems from the…
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Artikel Jurnal
Reactive oxygen species in health and disease
Abstract The traditional view of reactive oxygen species (ROS) as uniform toxicants has been superseded by the recognition of a fundamental radical/non-radical dichotomy. As radical and non-radical ROS differ in spatial and kinetic behaviors that dictate cellular impacts, understanding this…
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Artikel Jurnal
Metabolic reprogramming in cancer: dysregulation of glucose, lipid, and amino acid pathways and therapeutic opportunities
Abstract Metabolic reprogramming is a hallmark of cancer, including hepatocellular carcinoma (HCC). Cancer cells exhibit enhanced glucose and glutamine uptake, increased glycolysis, pentose phosphate pathway activity, de novo lipogenesis, and altered amino acid metabolism. However, the metabolic…
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Artikel Jurnal
Development and validation of a high-confidence diagnostic model integrating ctDNA methylation and serum biomarkers for early-stage hepatocellular carcinoma detection
Abstract Hepatocellular carcinoma (HCC) remains a leading cause of cancer-related mortality, with significantly improved prognosis when detected early in high-risk populations. Current serum biomarkers show limited sensitivity for early-stage disease. We developed and validated GAMAD, a multimodal…
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Artikel Jurnal
BRAF inhibitor resistance in melanoma: from resistance mechanisms to therapeutic innovations
Abstract BRAF inhibitors (BRAFi) have transformed the treatment of BRAF mutant melanoma, but inherent and acquired resistance remains a major barrier to curative outcomes. Resistance arises from interconnected mechanisms: genetic alterations reactivating the MAPK pathway or bypass cascades (e.g…
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Artikel Jurnal
Organoids: technology refining, current applications and future directions
Abstract Organoids are derived from pluripotent stem cells or tissue stem cells, progenitor cells, or differentiated cells from healthy or diseased tissues (e.g., tumors). Numerous organoid engineering strategies have been tested to support the culture, growth, proliferation, differentiation, and…
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Artikel Jurnal
FGF family in health and disease
Abstract Fibroblast growth factors (FGFs) form an evolutionarily conserved signaling system that governs embryonic patterning, tissue regeneration, and systemic metabolic homeostasis. Through coordinated interactions with fibroblast growth factor receptors (FGFRs) and context-specific cofactors…
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Artikel Jurnal
The extracellular matrix in inflammation and cancer
Abstract The extracellular matrix (ECM) forms a dynamic structure around cells, providing environmental cues, mechanical support, and tissue protection. It is composed of fibrous proteins, glycosaminoglycans (GAGs), proteoglycans, and glycoproteins. The molecular, physical, and mechanical…
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Artikel Jurnal
Interaction between transient receptor potential vanilloid 4 and glutamate NMDA receptor subunit 1 mediates endoplasmic reticulum stress and neuroinflammation in postoperative delirium
Abstract Postoperative delirium (POD) is a serious and prevalent neurocognitive complication that poses a major clinical challenge because its mechanism is unclear. This study identifies a pathogenic pathway centred on the direct interaction between transient receptor potential vanilloid 4 (TRPV4)…
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Artikel Jurnal
Zinc finger proteins (ZFPs) in health and disease
Abstract Zinc finger proteins (ZFPs), a vast superfamily of sequence-specific DNA and RNA-binding proteins, serve as master regulators of gene expression and cellular homeostasis. While traditionally studied for their roles in development, ZFPs have emerged as critical effectors and therapeutic…
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Artikel Jurnal
Targeting ferroptosis in cancer: from mechanistic insights to therapeutic approaches
Abstract Ferroptosis is a promising programmed cell death modality for cancer therapy, driven by iron overload and the accumulation of phospholipid peroxides that culminate in lethal membrane damage. Over the past decade, emerging evidence supports the concept that ferroptosis can be harnessed as…
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Artikel Jurnal
Ferroptosis in cardiovascular diseases: molecular mechanisms and a novel therapeutic target
Abstract Ferroptosis, a regulated cell death modality driven by iron accumulation and lipid peroxidation, has emerged as a pivotal pathophysiological mechanism across a broad spectrum of cardiovascular diseases (CVDs), which remain the leading cause of global mortality. Although robust preclinical…
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Artikel Jurnal
Safety pharmacology and toxicology of a novel nitroimidazooxazole antitubercular agent in SD rat and Beagle dogs
Abstract We developed JBD0131, a novel nitroimidazooxazole antitubercular agent, and conducted a comprehensive preclinical evaluation of its safety pharmacology, toxicology, and pharmacokinetics in SD rats and Beagle dogs. JBD0131 was well-tolerated in repeated-dose oral studies, with no…