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Osteoarthritis and Cartilage Open
Scopus
ISSN 2665-9131 · Elsevier · 741 artikel di indeks
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Artikel Jurnal
Exploring the bidirectional temporal association between daily knee pain and physical activity in people with knee osteoarthritis: An exploratory smartwatch study
Objective: Effective physical activity interventions for knee osteoarthritis (OA) require an understanding of the relationship between physical activity and pain. Using daily concurrent activity and pain measurements, we explored day-to-day changes and the bidirectional temporal association at…
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Artikel Jurnal
A small lipidated peptide targeting NaV1.8 channels attenuates osteoarthritic pain behavior and prevents bone erosion
Objective: In clinical practice, intra-articular therapies are commonly used for the management of osteoarthritis (OA) pain. However, these current treatments for OA-related pain are recognized for compromising joint integrity over time. Previously, we demonstrated that disrupting the interaction…
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Artikel Jurnal
A consumer co-designed community physical activity program for Australians living with osteoarthritis (CASCADE-OA): A randomised controlled trial protocol
Objective: This protocol will detail the methodology of the CASCADE-OA trial that will determine the effectiveness of an evidence-based and co-designed walking program, Walk with Ease Australia in increasing physical activity levels in people with osteoarthritis (OA). Design: We will undertake a…
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Artikel Jurnal
The infrapatellar fat pad mediates environmental exposure for clinical outcomes in knee osteoarthritis
Objective: This cross-sectional study aimed to investigate whether the infrapatellar fat pad (IPFP) mediates the relationship between environmental exposures and clinical symptoms in patients with knee osteoarthritis (KOA). Methods: A total of 108 participants with KOA were included in this study…
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Artikel Jurnal
MULTIple or ONE home strengthening exercise(s) for knee osteoarthritis: Protocol for the MULTI-ONE randomised controlled trial
Objective: To determine the effectiveness of a prescribed home exercise program comprised of a single strengthening exercise compared to i) a program with multiple (five) strengthening exercises and ii) control (usual care) for reducing walking pain in people with knee osteoarthritis (OA). Design…
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Artikel Jurnal
Exploratory analysis of the 2-year changes in knee cartilage thickness and transverse relaxation time (T2) in ACL-injured versus healthy participants
Objective: To investigate the 2-year changes in cartilage thickness and transverse relaxation time (T2) in magnetic resonance images (MRI) of ACL-injured (ACL_in) and uninjured contralateral knees (ACL_unin), compared to healthy controls (HEA). Method: Baseline and 2-year follow-up MRIs were…
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Artikel Jurnal
Association between symptomatic knee osteoarthritis and health-related quality of life in individuals with type 2 diabetes: A cross-sectional study
Objective: Knee osteoarthritis (OA) and type 2 diabetes (T2D) commonly coexist, but their combined impact on health-related quality of life (HRQoL) remains understudied. We assessed the association between symptomatic knee OA and HRQoL in individuals with T2D and explored potential explanations…
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Artikel Jurnal
The severity of fatigue and its interplay with biological and psychological factors in people with hand osteoarthritis – Results from the Nor-Hand study
Background: Fatigue represents a concurrent yet uncommonly addressed symptom among people with hand osteoarthritis (OA). We aimed to explore fatigue severity and its interplay with other variables among hand OA patients. Methods: We used baseline data collected in the Nor-Hand study, a cohort…
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Artikel Jurnal
Investigating predictors of pain events during trials of knee osteoarthritis: A post-hoc analysis of two phase III trials
Objective: This study aims to explore the associations between clinical characteristics, including medical history, and the frequency, severity, and type of pain events (PEs) over a two-year period in patients with knee osteoarthritis (OA). Design: A post-hoc analysis was conducted on data from two…
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Artikel Jurnal
Studying the formation of the zone of calcified cartilage in bovine cartilage explants ex vivo
Objective: The zone of calcified cartilage (ZCC) connects non-calcified articular cartilage to the subchondral bone, acting as transitional layer. Regeneration of this layer is key for cartilage repair but remains a challenge. Knowledge on the formation of this layer during development is limited…
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High glucose upregulates BMAL1 in chondrocytes from macroscopically normal and osteoarthritic human cartilage but this only results in increased collagen synthesis in chondrocytes from macroscopically normal cartilage regions
Objective: Osteoarthritic (OA) chondrocytes exhibit limited capacity for new collagen synthesis. High glucose promotes collagen I and III production by fibroblasts. The purpose of this study was to determine if it also promotes collagen II (COL2) synthesis by chondrocytes. Design: Chondrocytes…
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Artikel Jurnal
The stability of pain phenotypes in people with hand osteoarthritis – results from the NOR-HAND study
Objective: In a hand osteoarthritis (OA) cohort, we aimed to explore pain phenotypes and characterize their stabilities using the multidimensional framework developed by The Initiative on Methods, Measurement and Pain Assessment in Clinical Trials (IMMPACT). Methods: We included participants…
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Artikel Jurnal
A randomized, double-blind, placebo-controlled and dose-ranging study to evaluate the safety and efficacy of XG005 in subjects with painful osteoarthritis of the knee
Objective: Symptomatic treatment for osteoarthritis (OA) remains a major unmet need. This trial evaluated XG005, a novel, non-opioid, dual-mechanism agent targeting both inflammatory and neuropathic pathways in patients with knee OA. Design: This randomized, double-blind, placebo-controlled study…
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Artikel Jurnal
Prevalence and impact of sleep disorders in osteoarthritis: A systematic review and meta-analysisKeypoints
Objective: Sleep disorders (SD) are increasingly recognized as a major contributor to the symptom burden of osteoarthritis (OA), yet their epidemiology and clinical impact remain insufficiently characterized. This systematic literature review with meta-analysis aims to quantify the prevalence of SD…
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Artikel Jurnal
Clinical characteristics and physical activity levels of patients with knee osteoarthritis with and without a previous knee injury: A cross-sectional studySignificance and Innovations
Objective: To compare clinical characteristics and physical activity levels of patients with mild-to-moderate knee osteoarthritis (OA). Methods: A total of 262 individuals with mild-to-moderate knee OA recruited from the Technology, Exercise Programming, and Activity Prescription for Enhanced…
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Artikel Jurnal
Identification of alkaline phosphatase as a putative biomarker of anti-NGF treatment-associated arthropathies: Machine learning-assisted analyses of clinical trial data
Objective: Nerve growth factor (NGF) inhibitors have been shown to provide pain relief in patients with osteoarthritis but are associated with adjudicated arthropathies (AAs). Exploratory analyses were performed to identify whether peripheral biomarkers routinely collected in trials can predict…