139 hasil
Menampilkan 1–20 · 0,14 detik · RSS
Current Research in Neurobiology
Scopus
ISSN 2665-945X · Elsevier · 139 artikel di indeks
-
Artikel Jurnal
A tool for high-throughput quantification of sleep-wake transitions in data from noninvasive piezoelectric cage systems
Quantifying sleep quality in rodent models is critical for understanding its impact on neurological health and disease. Piezoelectric cage systems enable rapid, noninvasive measurement of multiple sleep metrics for large sample sizes of rodents. Although sleep duration is commonly reported, sleep…
-
Artikel Jurnal
Context-sensitive V1 activity that depends on both coherence and surprise
We investigate how information processing in the early visual cortex, which is tuned to the statistical regularities of sensory inputs, depends critically on the context in which those inputs occur. Neurobiologically inspired computational frameworks of visual processing emphasise functional…
-
Artikel Jurnal
Instructive signals drive learning through behavioral timescale synaptic plasticity in the hippocampus and beyond
Learning requires the brain to link experience to lasting changes in neural activity, yet most experiences unfold over timescales far longer than those of classical synaptic plasticity mechanisms. Behavioral timescale synaptic plasticity (BTSP) has emerged as a candidate mechanism that bridges this…
-
Artikel Jurnal
Exploration of circulating metabolites in infants with abusive head trauma
Abusive head trauma (AHT) is a severe form of traumatic brain injury (TBI) and causes significant brain lesions by vigorous shaking. It is the leading cause of mortality and morbidity in children under 2 years of age. If not fatal, AHT can result in severe disabilities, often requiring long-term…
-
Artikel Jurnal
Rapid degeneration and neurochemical plasticity of the lateral geniculate nucleus following lesions of the primary visual cortex in marmoset monkeys
Lesions of the primary visual cortex (V1) cause retrograde neuronal degeneration, volume loss and neurochemical changes in the lateral geniculate nucleus (LGN). Here we characterised the timeline of these processes in adult marmoset monkeys, after various recovery times following unilateral V1…
-
Artikel Jurnal
Distinct functional cerebral hypersensitivity networks during incisional and inflammatory pain in rats
Although the pathophysiology of pain has been investigated tremendously, there are still many open questions with regard to specific pain entities and their pain-related symptoms. To increase the translational impact of (preclinical) animal neuroimaging pain studies, the use of disease-specific…
-
Artikel Jurnal
Temporal dynamics of offline transcranial ultrasound stimulation
Transcranial ultrasound stimulation (TUS) is a promising non-invasive neuromodulation modality, characterized by deep-brain accuracy and the capability to induce longer-lasting effects. However, most TUS datasets are underpowered, hampering efforts to identify TUS longevity and temporal dynamics…
-
Artikel Jurnal
Retinotopic biases in contextual feedback signals to V1 for object and scene processing
Identifying the objects embedded in natural scenes relies on recurrent processing between lower and higher visual areas. How is cortical feedback information related to objects and scenes organised in lower visual areas? The spatial organisation of cortical feedback converging in early visual…
-
Artikel Jurnal
Neuropeptide Y modulates the electrical activity of subfornical organ neurons
The subfornical organ (SFO) is a sensory circumventricular organ, lacking a blood-brain barrier. It is well-recognized as a key center for detection and integration of osmotic, ionic and hormonal signals for maintenance of hydromineral balance and cardiovascular regulation. Recently, the SFO has…
-
Artikel Jurnal
Regulation of perisomatic synapses from cholecystokinin basket interneurons through NrCAM and Ankyrin B
The perisomatic region of cortical pyramidal neurons (PNs) integrates local and long-range inputs and regulates firing. This domain receives GABAergic inputs from cholecystokinin (CCK)- and Parvalbumin (PV)-expressing basket cells (BCs) but how synaptic contacts are established is unclear…
-
Artikel Jurnal
Unveiling the development of human voice perception: Neurobiological mechanisms and pathophysiology
The human voice is a critical stimulus for the auditory system that promotes social connection, informs the listener about identity and emotion, and acts as the carrier for spoken language. Research on voice processing in adults has informed our understanding of the unique status of the human voice…
-
Artikel Jurnal
Cellular mechanisms of cooperative context-sensitive predictive inference
We argue that prediction success maximization is a basic objective of cognition and cortex, that it is compatible with but distinct from prediction error minimization, that neither objective requires subtractive coding, that there is clear neurobiological evidence for the amplification of predicted…
-
Artikel Jurnal
Hearing loss in juvenile rats leads to excessive play fighting and hyperactivity, mild cognitive deficits and altered neuronal activity in the prefrontal cortex
Background: In children, hearing loss has been associated with hyperactivity, disturbed social interaction, and risk of cognitive disturbances. Mechanistic explanations of these relations sometimes involve language. To investigate the effect of hearing loss on behavioral deficits in the absence of…
-
Artikel Jurnal
A psychophysically-tuned computational model of human primary visual cortex produces geometric optical illusions
Geometric optical illusions (GOIs) are mismatches between physical stimuli and perception. GOIs provide an access point to study the interplay between sensation and perception, Yet, there is relatively scant quantitative investigation of the extent to which different GOIs rely on similar or…
-
Artikel Jurnal
Analysis of the neuromuscular deficits caused by STAM1 deficiency
The endosomal sorting complexes required for transport (ESCRT) pathway is composed of a series of protein complexes that are essential for sorting cargo through the endosome. In neurons, the ESCRT pathway is a key mediator of many cellular pathways that regulate neuronal morphogenesis as well as…
-
Artikel Jurnal
Ablation of Iron Regulatory Protein 2 produces a neurological disorder characterized by motor, somatosensory, and executive dysfunction in mice
Iron is an important cofactor for many proteins and is used to create Fe-S clusters and heme prosthetic groups that enzymes use to catalyze enzymatic reactions. Proteins involved in the import, export, and sequestration of iron are regulated by Iron Regulatory Proteins (IRPs). Recently, a patient…
-
Artikel Jurnal
Modeling for neurosurgical laser interstitial thermal therapy with and without intracranial recording electrodes
Laser thermal ablation has become a prominent neurosurgical treatment approach, but in epilepsy patients it cannot currently be safely implemented with intracranial recording electrodes that are used to study interictal or epileptiform activity. There is a pressing need for computational models of…