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JACC: Case Reports
Scopus
ISSN 2666-0849 · Elsevier · 1.618 artikel di indeks
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Artikel Jurnal
Donut Morphology of Cardiac Amyloidosis
Background: Transthyretin cardiac amyloidosis (ATTR-CM) typically manifests with diffuse biventricular wall thickening, and technetium-99m pyrophosphate scintigraphy is highly accurate in this setting. False-negative results may occur, however, in early-stage disease when amyloid infiltration is…
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Systemic Oxalosis Mimicking Transthyretin Amyloid Cardiomyopathy
Background: Technetium-99m pyrophosphate (Tc-99m PYP) scintigraphy is a noninvasive imaging modality in the diagnosis of transthyretin amyloid cardiomyopathy (ATTR-CM), though false positive results may result in adverse clinical outcomes. Case Summary: A 53-year-old man with a history of heart…
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Light Chain Cardiac Amyloidosis With Skeletal Muscle Weakness
Background: Amyloid light chain (AL) amyloidosis can manifest with heterogeneous, multisystem features. Cardiac involvement is common and drives prognosis. Case Summary: A 54-year-old man presented with proximal muscle weakness, autonomic and gastrointestinal symptoms, and exertional intolerance…
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Abnormal Cardiac PET Imaging in ATTR Amyloidosis
Background: Transthyretin amyloidosis (ATTR) is an infiltrative cardiomyopathy caused by deposition of misfolded transthyretin protein in the myocardium. Diagnosis typically relies on technetium-99m–based imaging or magnetic resonance imaging. Case Summary: A 72-year-old man presented for…
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When Hematologic Response Does Not Translate to Cardiac Recovery in AL Amyloidosis
Background: Cardiac light-chain (AL) amyloidosis carries high early mortality due to rapid hemodynamic deterioration. Hematologic response does not always translate into cardiac recovery, particularly in advanced disease. Case Summary: A 66-year-old woman presented with dyspnea and chronic edema…
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Hereditary Transthyretin Cardiac Amyloidosis With Severe Left Ventricular Outflow Tract Obstruction Mimicking Hypertrophic Obstructive Cardiomyopathy
Background: Cardiac amyloidosis may mimic hypertrophic cardiomyopathy; however, severe left ventricular outflow tract (LVOT) obstruction is rarely described in transthyretin (TTR) cardiac amyloidosis. Case Summary: A 49-year-old man presented with exertional dyspnea and presyncope. Echocardiography…
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Rare Hereditary Cardiac Amyloidosis Treated With SGLT2 Inhibitor
Background: Rare hereditary cardiac amyloidosis (CA) may mimic transthyretin or light-chain cardiomyopathy, and reports for effective therapy in these entities are limited. Case Summary: A 61-year-old man presented with progressive heart failure (NYHA functional class III). Medical history included…
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Smartwatch-Detected Sinus Tachycardia Unmasking AL Cardiac Amyloidosis in a Young Adult
Background: The clinical presentation of immunoglobulin light-chain (AL) can be very heterogenous resulting in delayed diagnosis and treatment. The use of wearable health technology is rapidly expanding. This case explores the important role this technology can play in the diagnosis of cardiac…
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Amyloid Light Chain Amyloidosis Involving the Heart and Temporal Arteries, Mimicking Giant Cell Arteritis
Background: Amyloid light chain (AL) amyloidosis is an uncommon multisystem condition. We report a globally unique case of a patient with AL amyloidosis affecting the heart and temporal arteries. Case Summary: A 74-year-old man presented with jaw claudication and temporal artery tenderness and was…
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Artikel Jurnal
Successful Heart Transplantation in a Patient With Triple Infiltrative Cardiomyopathy
Background: Although “dual pathology” cardiac amyloidosis cases (amyloid light chain [AL] and transthyretin [TTR]) have been described, the coexistence of cardiac sarcoidosis with TTR amyloidosis is extremely rare, with only 2 case reports described in Japan to date. Report Summary: We describe a…
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Artikel Jurnal
Apolipoprotein A-IV Cardiac Amyloidosis Presenting as Massive Ventricular Wall Thickening Mimicking Hypertrophic Cardiomyopathy
Background: Apolipoprotein A-IV amyloidosis (AApoAIV) is a rare systemic amyloidosis that can involve the heart and mimic hypertrophic cardiomyopathy. Case Summary: A 64-year-old woman with presumed hypertrophic cardiomyopathy presented with dyspnea. Imaging showed severe left ventricular wall…
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Artikel Jurnal
Abnormal Cardiovascular Responses During Orthostatic Hypotension in Cardiac Amyloidosis Revealed by Semi-Sitting/Standing Stress Echocardiography
Background: Mechanisms of orthostatic hypotension (OH) in cardiac amyloidosis (CA) patients remain largely unclarified. Case Summary: We performed semi-sitting/standing stress echocardiography in 6 healthy volunteers, 5 patients with CA but without OH [CA/OH(−)], and 4 with CA and OH [CA/OH(+)]…
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Artikel Jurnal
Hereditary Transthyretin Amyloidosis in Brazilian Amazon Caused by a Globally Rare Variant Predominant in Asia
Background: Hereditary transthyretin amyloidosis (ATTRv) exhibits marked phenotypic heterogeneity. The p.Asp58Ala variant is globally rare and has not been reported in major Brazilian epidemiologic studies. Case Summary: We report 10 patients with ATTRv-p.Asp58Ala, including 6 index cases and 4…
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Perugini Grade 3 Uptake Does Not Exclude AL Cardiac Amyloidosis
Background: Bone scintigraphy has improved noninvasive diagnosis of cardiac amyloidosis, but interpretation remains challenging when monoclonal gammopathy is present. Case Summary: A 76-year-old man with heart failure with preserved ejection fraction, chronic kidney disease, permanent atrial…
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Artikel Jurnal
Unmasking AL Cardiac Amyloidosis During Familial Cardiomyopathy Screening
Background: Amyloid light-chain (AL) amyloidosis is a life-threatening plasma cell disorder in which prognosis is largely determined by cardiac involvement. Early diagnosis remains uncommon. Case Summary: A 65-year-old asymptomatic man was referred for familial hypertrophic cardiomyopathy…
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Obstructive Intramural Coronary Amyloidosis
Background: Obstructive intramural coronary amyloidosis (OICA) can be the unique manifestation of cardiac amyloidosis (CA). The clinical onset may mimic ischemic heart disease as microvascular angina or myocardial infarction. Case Summary: We report an 83-year-old man with long-standing angina…
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Artikel Jurnal
Transthyretin Cardiac Amyloidosis in a Safety-Net Hospital
Transthyretin cardiac amyloidosis (ATTR-CA) is profoundly underdiagnosed in Afro-Caribbean populations despite the high prevalence of the Val122Ile (V142Ile) variant (approximately 3.4% carrier frequency among self-identified Black individuals in the United States). This case series describes 10…
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Artikel Jurnal
ATTR-CM in Patients With Clinically Significant Plasma Cell Dyscrasias
Background: Suspicion and diagnosis of transthyretin cardiac amyloidosis (ATTR-CM) in patients with clinically significant plasma cell disorders is challenging. Timely identification of both light chain (AL) and ATTR-CM is essential for optimizing patient outcomes. Case Summary: We report 6…
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Artikel Jurnal
Coexistence of Hypertrophic Cardiomyopathy and Hereditary Transthyretin Amyloid Cardiomyopathy
Background: Left ventricular wall thickening may result from disease such as hypertrophic cardiomyopathy (HCM) or infiltrative cardiomyopathies such as transthyretin amyloidosis (ATTR). When features of both conditions coexist, distinguishing the dominant pathology can be challenging and may…
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Artikel Jurnal
3 Discordant Extracardiac Amyloid Proteins Highlighting Bystander Deposition in a Case of Light-Chain Amyloid Cardiomyopathy
Background: Accurate differentiation of immunoglobulin light-chain (AL) from transthyretin (ATTR) amyloid cardiomyopathy is critical, as misclassification may delay appropriate therapy and worsen outcomes. Case Summary: An 80-year-old woman with incidental gallbladder AL lambda and ApoA-IV amyloid…
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