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Brain, Behavior, & Immunity - Health
Scopus
ISSN 2666-3546 · Elsevier · 1.191 artikel di indeks
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Artikel Jurnal
The role of oral contraceptive use in associations of concussion history with kynurenine pathway metabolites, inflammation, and psychological symptoms in female athletes
Concussion history is linked to increased risk of psychological symptoms, potentially through inflammation-driven activation of the kynurenine pathway (KP). Use of oral contraceptives (OC) is also associated with increased inflammation, reduced protective kynurenic acid (KynA), and, in some cases…
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Artikel Jurnal
A Stress-Neuroendocrine-Myeloid Inflammation Axis Is Associated with the Progression of Ménière's Disease
Background: Ménière disease (MD) is a chronic inner ear disorder of unknown etiology. Although an immune-inflammatory link is suspected, the upstream triggers and cellular mechanisms connecting psychosocial stress to inner ear pathology remain poorly defined. This study aimed to investigate the…
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Early-life maternal probiotic supplementation programs sex- and region–specific gene expression in the adult offspring brain
Background: The maternal perinatal environment shapes brain development and long-term neurodevelopmental trajectories. Probiotic supplementation during this period has emerged as a promising strategy to support healthy neurodevelopmental outcomes through modulation of immune and synaptic plasticity…
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The role of health behaviors in links between stress and epigenetic aging
High levels of stress are associated with accelerated epigenetic aging and health risks. However, less is known about the independent effects of different types of stress and whether these effects are explained by unhealthy behaviors. This study involved 1308 adults from the Midlife in the United…
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Dysregulated miRNAs and downstream gene expression associated with poor treatment response in first-episode psychosis
Background: Treatment response in first-episode psychosis (FEP) is highly variable, and reliable biomarkers for poor outcomes remain limited. MicroRNAs (miRNAs), important post-transcriptional regulators, have been implicated in psychotic disorders. However, genome-wide miRNA profiling and analyses…
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Stable serum peptidoglycan fragment levels do not support leaky gut in the acute phase or at one month following “mild” traumatic brain injury: A preliminary study
The gut-brain axis is increasingly recognized as contributor to the pathophysiology of brain disorders, in part through its influence on inflammation. Impaired gut health can lead to so-called leaky gut, allowing bacterial cell wall fragments such as peptidoglycan-derived muramyl dipeptide (MDP) to…
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Immune system up-regulation in securely attached infants during early childhood
Early caregiving relationships shape the coordination of stress and immune systems, yet their biological correlates in early infancy remain insufficiently understood. This study examined whether attachment relationships are associated with mucosal immune function and stress physiology. Thirty-five…
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Assessing the repurposing potential of disease-modifying antirheumatic drug targets to reduce Alzheimer's disease risk: a Mendelian randomization study
Background: Systemic inflammation plays a key role in the development and progression of Alzheimer's disease (AD). However, the repurposing potential of select anti-inflammatory drug targets for AD treatment remains unclear. Methods: Two-sample Mendelian randomization (MR) and colocalization…
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Endotoxin-induced inflammation promotes, via the adrenomedullary system, a hyperglycemic and anti-inflammatory reflex
Immune challenges elicit significant physiological responses which are coordinated by the central nervous system. Among these is the sympathetic system-mediated anti-inflammatory reflex, which suppresses the TNF response. The sympathetic system has two main effector pathways: direct organ-targeted…
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Association between influenza A virus and SARS-CoV-2 infections and mood disorders
Acute respiratory infections (ARIs) are among the most common infectious diseases encountered in clinical practice, with approximately 70–80 % of cases attributed to viral pathogens. Among these, seasonal influenza A virus (IAV) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)…
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A network analysis of lifetime stressor exposure, mental health, well-being, and immune cell mobilisation to acute stressors in young adults
Many young adults experience mental ill-health which is increasing over time. From a theoretical perspective, the accumulation of stressors experienced over the lifespan may be an important factor in influencing the mental health and well-being of young adults. Although continued exposure to…
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Immunoglobulin G complexes from post-infectious ME/CFS, including post-COVID ME/CFS disrupt cellular energetics and alter inflammatory marker secretion
Background: Autoimmunity is a key clinical feature in both post-infectious Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and Post-Acute Sequelae of COVID (PASC). Passive transfer of immunoglobulins from patients' sera into mice induces some clinical features of PASC. However, the…
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Optimal doses of mind-body exercise on neuroinflammation in individuals with neuropsychiatric disorders: A systematic review and dose-response meta-analysis
Background: Mind-body exercises (MBEs), including Tai Chi (TC), Qigong (QG), Yoga (YG), and Mindfulness-Based Stress Reduction (MBSR), show promise in neuropsychiatric rehabilitation by modulating neuroinflammation. This study systematically examines the effects of MBEs on neuroinflammation-related…
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Systemic inflammation and its associations in acute moderate-severe Traumatic Brain Injury: a cross-sectional study
Traumatic Brain Injury (TBI) triggers an acute systemic inflammatory response, which may impact outcomes. This response may interact with pre-existing factors linked to inflammation, such as age, to influence outcomes. Previous studies have typically measured few cytokines, but high-dimensional…
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AQP4-IgG and mood disorders: Case series of neuromyelitis optica spectrum disorder
Neuromyelitis optica spectrum disorders (NMOSD) are autoimmune inflammatory demyelinating conditions primarily affecting the optic nerves and spinal cord. While NMOSD pathogenesis is mediated by aquaporin-4 antibody (AQP4-IgG) autoimmunity, increasing evidence suggests significant comorbidity with…
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Macrostructural, microstructural, and cellular effects of neuroinflammation on the mouse brain
Neuroinflammation is increasingly implicated in post-infectious brain atrophy and cognitive impairment, as well as the etiology of neurodegenerative and psychiatric disorders. Here, we employed an established mouse model of neuroinflammation (systemic lipopolysaccharide [LPS]) and studied its…
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Immune dysregulation and neuroinflammation in bipolar disorder: Pathophysiological insights and therapeutic perspectives
Bipolar disorder (BD) is increasingly associated with immune system dysregulation encompassing both peripheral and central components. Peripheral low-grade inflammation, marked by elevated proinflammatory cytokines and impaired anti-inflammatory responses, contributes to systemic immune imbalance…
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A review of neurophysiological relationships between sleep disorders and depression
This review critically synthesizes current neurophysiological findings on the comorbidity between depression and sleep disorders. Drawing upon a multidisciplinary body of literature, the paper delineates overlapping neurochemical, hormonal, and inflammatory mechanisms. Further, it explores the role…
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