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Brain Disorders
Scopus
ISSN 2666-4593 · Elsevier · 305 artikel di indeks
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Artikel Jurnal
Safety and efficacy of continuous dimethyl fumarate treatment during conception, pregnancy, and lactation in females with multiple sclerosis: A case series
Background: There is a delicate balance between managing the underlying disease and avoiding potential risks to the fetus in pregnant MS patients. This study aims to assess the impacts of continuing dimethyl fumarate (DMF) before, during, and after pregnancy in women with MS. Methods: This…
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Artikel Jurnal
Prospects of the therapeutic approaches of ketogenic diet in epilepsy management
The ketogenic diet (KD) is a low-carbohydrate, high-fat diet. For many patients with uncontrolled epilepsy, KD treatments provide a proven non-pharmacological therapy alternative. This is particularly relevant for children with particular epilepsy syndromes and metabolic abnormalities. The aim of…
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Artikel Jurnal
Distribution patterns of brain MS plaques among Iranian patients: A gender-based MRI study
Aims: This study aimed to characterize the distribution of multiple sclerosis (MS) plaques in the brains of Iranian patients using MRI and to assess gender-based differences in lesion involvement. Findings were compared with international data to identify region-specific patterns. Methods: We…
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Artikel Jurnal
GLP-1 receptor agonists in diabetes-associated neurological disorders
Background/Objectives: Diabetes is associated with complications in the central and peripheral nervous systems, including Parkinson’s disease, stroke, depression, epilepsy, diabetic peripheral neuropathy, and diabetic retinopathy. Evidence indicates that GLP-1 RAs may offer neuroprotective and…
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Artikel Jurnal
Cognitive dysfunction in adult moyamoya disease: frontal hemodynamics, microstructural vulnerability, and surgical considerations, with emphasis on non-stroke presentations
Objective: Neurocognitive dysfunction is common in adult moyamoya disease (MMD), including in patients without overt cerebral infarction. Despite this, cognitive status is not incorporated into revascularization decision-making. We examine evidence for cognitive dysfunction in non-stroke adult MMD…
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Artikel Jurnal
Parietal and prefrontal transcranial magnetic stimulation (TMS) for mild cognitive impairment (MCI): A pilot randomized clinical trial
Background: Even though studies of repetitive transcranial magnetic stimulation (rTMS) have demonstrated improvements in cognitive function, we know little about what site of stimulation would be ideal for improving memory. Methods: We investigated two sites: (1) the dorsolateral prefrontal cortex…
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Artikel Jurnal
Augmented intelligence in aneurysm care: A systematic review and meta-analysis of diagnostic performance in intracranial aneurysm rupture risk assessment
Background: Accurate assessment of intracranial aneurysm rupture risk remains challenging, with conventional clinical scores showing limited predictive performance. Artificial intelligence (AI) has emerged as a potential adjunct to imaging-based risk stratification, yet the relative performance of…
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Artikel Jurnal
Main diagnoses and short-term disposition in a rapid-access neurology clinic: A 12-month service evaluation in a tertiary center in Argentina
Background: Rapid-access neurology (“hot clinic”) pathways provide timely specialist assessment for urgent neurological complaints. Evidence from middle-income settings remains scarce. Methods: We conducted a 12-month retrospective evaluation of consecutive referrals to a rapid-access neurology…
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Artikel Jurnal
Ionizing radiation acutely stimulates iron accumulation in the olfactory bulb
Radiation therapy leads to structural and functional changes in the brain resulting in a time-dependent cognitive decline. There are limited options to ameliorate this side-effect of therapy that significantly impacts patient quality of life; thus, a more robust understanding of the radiation…
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Artikel Jurnal
Lidocaine mitigates cognitive decline in elderly patients after video-assisted thoracoscopic surgery: A double-blind randomized controlled clinical trial
Background: : Postoperative cognitive decline (POCD) can occur in elderly patients after surgery and is associated with poor outcomes. Lidocaine is an antiarrhythmic and anesthetic agent, with analgesic and anti-inflammatory properties. We aimed to explore the influence of lidocaine on POCD in…
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Artikel Jurnal
Assessment of the predictive value of vomiting versus physical examination for a CT scan in children with head injury
Background: Head injuries are common in children of all ages. While most are minor and do not require intervention, severe cases remain a leading cause of mortality and disability. Identifying minor head trauma with a significant risk of intracranial injury is challenging. Vomiting is a frequent…
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Artikel Jurnal
Integration of the serum metabolome and gut microbiome underscores the importance of altered lipid metabolism and potential immune modulation in Parkinson's Disease
Introduction: Single-omics studies have deepened our understanding of disease-related molecular processes, though integrated approaches are needed to uncover cross-system interactions. We previously reported changes in the serum metabolome and gut microbiome in Parkinson’s disease (PD). To build on…
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Artikel Jurnal
Guillain–Barré syndrome following dengue infection in an adult patient: a case report
Background: Dengue fever is a viral disease that presents with a wide range of neurological features. Although less frequent, Guillain–Barré Syndrome (GBS) is a life-threatening, postinfectious neurological sequela. Case summary: A 44-year-old Bangladeshi male presented with flaccid quadriplegia…
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Heterozygous FBXO7 as potential genetic modifiers in early-onset Parkinson’s disease with levodopa responsive non-motor features
Objective: To report a retrospective clinical series of four patients diagnosed with early-onset Parkinson’s disease (EOPD) carrying heterozygous variants of uncertain significance (VUSs) in the FBXO7 gene. Background: FBXO7 encodes an F-box-domain-containing protein involved in the mitophagy…
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Artikel Jurnal
Genetic characterisation of ATXN2 in Australian amyotrophic lateral sclerosis
Large expansions of a trinucleotide repeat encoding a polyglutamine tract in ATXN2 are a known cause of spinocerebellar ataxia 2, and intermediate length expansions in this gene have been reported as a risk factor and phenotypic modifier for amyotrophic lateral sclerosis (ALS). Here we present a…
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Artikel Jurnal
Spinal cord compression secondary to spinal extradural myeloid sarcoma in acute myeloid leukaemia: A case report and literature review
Introduction: Myeloid sarcoma (MS) is a rare pathology that includes immature myeloid progenitor cells and is an infrequent form of acute myeloid leukemia (AML). It may occur de novo or be associated with other myeloproliferative disorders. Spinal involvement is rare but has the potential to result…
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Artikel Jurnal
CRISPR-Cas9 gene editing in neuropsychiatric disorders: Challenges and promising avenues
This review explores the transformative potential of CRISPR-Cas9 gene editing technology in neuropsychiatric disorders. Neuropsychiatric conditions, marked by genetic and environmental factors, pose significant global health challenges. Traditional treatments often address symptoms, leaving…