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Current Research in Microbial Sciences
Scopus
ISSN 2666-5174 · Elsevier · 607 artikel di indeks
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Artikel Jurnal
Resistance to disinfection emerges in
Cleaning and disinfection (C&D) of food-contact surfaces is an essential measure to prevent microbial contamination during food processing. These procedures commonly involve the use of biocides to reduce or eliminate foodborne pathogens such as Salmonella spp. Among the available biocides, amines…
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Gut microbial allies and adversaries in SARS-CoV-2 infection
While the immediate threat of coronavirus disease 2019 (COVID-19) has diminished, the World Health Organization (WHO) still considers it an important public health concern, as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to circulate at considerable levels. The gut plays…
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Nutrient-driven small-colony variants as an adaptive outcome in Carbapenem-resistant Acinetobacter baumannii
Carbapenem-resistant Acinetobacter baumannii (CRAB) is a serious threat, and resistance is emerging to cefiderocol, one of the few remaining treatment options. However, how host micronutrients drive bacterial adaptation under antibiotic pressure is poorly defined. Using the AB5075 and CDC AR Bank…
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Organic acid-based deep eutectic solvents (DESs) are potent antimicrobial agents against antibiotic-resistant bacteria and viruses
The escalating threat of antibiotic-resistant bacteria, biofilms and viral contamination in the healthcare and food industries threatens global health and requires the development of innovative antimicrobials. Deep eutectic solvents (DESs) have attracted attention as antimicrobial candidates, but…
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Integrated omics reveal a unique antibacterial mechanism of action for the small molecule HSI#6
The continuous risk of antibiotic resistance development underscores the demand for new agents with mechanisms distinct from existing antibacterial drugs. Here, we investigated HSI#6, a small-molecule antibacterial previously identified as a SecA activator, using integrated omics and functional…
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Smolstatin1, a unique cystatin-like stefin of Sphaerospora molnari, is essential for parasite development
Stefins, members of the cystatin superfamily, regulate cysteine proteases, yet their roles in early-branching metazoans remain poorly defined. Here, we characterize Smolstatin1, a cystatin-like stefin from the myxozoan Sphaerospora molnari, a common carp pathogen. Phylogenetic analysis places…
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Mutations in the superoxide-responsive regulator SoxR confer fluoroquinolone resistance in Stenotrophomonas maltophilia
Stenotrophomonas maltophilia is a multidrug-resistant Gram-negative opportunistic pathogen. Its antimicrobial resistance arises from intrinsic traits and acquired mechanisms. Overexpression of drug efflux transporters is one of the key mechanisms mediating high-level antibiotic resistance. These…
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Antiviral potential of black tea and blueberry extracts against monkeypox virus by targeting orthopoxvirus surface proteins
Monkeypox virus (MPXV) outbreaks primarily affect resource-limited regions in Africa, highlighting an urgent need for low-cost, accessible therapeutics. Food-medicine homologous (FMH) substances, which are bioactive food components with medicinal properties, offer a promising therapeutic avenue…
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Uncovering the endophytic bacterial diversity and crop improvement potential under salinity stress in the halophyte Halocnemum strobilaceum
Halophytes are considered promising sources of halophilic and halotolerant bacteria for biotechnological applications in agriculture, particularly as soil salinization threatens crop yield. Although interest in halophyte-associated endophytic bacteria has increased in recent years, their diversity…
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Bacterial warfare at the molecular level: Pseudoalteromonas sp. H2 disrupts Vibrio splendidus membrane integrity via ClpP-CheW2 regulation
In mariculture ecosystems where Vibrio spp. are predominant pathogens, effective biocontrol through antagonistic probiotics remains an unresolved biological challenge. Here, the Pseudoalteromonas sp. H2 strain was first determined to inhibit Vibrio splendidus AJ01 growth through contact-dependent…
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Multi-omics analysis-based insights into the microbial community composition and flavor development potentiality of different varieties of sorghum (Sorghum bicolor L. Moench) fermented into Sesame flavor Baijiu
Sorghum is a key raw ingredient in the fermentation of Sesame-flavor Baijiu (SFB). However, studies on the microbial and metabolic dynamics of sorghum varieties on SFB fermentation is limited. In this study, microbial and flavor differences during SFB fermentation of three sorghum varieties…
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Bifidobacterium stercoris KC84 attenuates IBS-D-like symptoms via modulation of serotonin-related pathways and dendritic cell-mediated IFN-β induction
Irritable bowel syndrome with diarrhea (IBS-D) is a prevalent disorder that significantly impairs quality of life, yet therapeutic advances remain limited. Serotonin dysregulation, primarily driven by enterochromaffin cells in the intestinal epithelium, is central to IBS-D pathogenesis. We…
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Manganese homeostasis supports Stenotrophomonas maltophilia oxidative stress defense and replication in Acanthamoeba castellanii phagosomes
Manganese homeostasis is essential for the environmental adaptability and pathogenic potential of Stenotrophomonas maltophilia, a bacterium that thrives across diverse and fluctuating environments. Here, we characterize the manganese homeostasis network of S. maltophilia strain Sm18, identifying a…
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Metagenomic profiling of ocular surface microbiome alterations in patients with progressive supranuclear palsy-Richardson’s syndrome
This study employed shotgun metagenomic sequencing to characterize the ocular surface microbiome in 20 progressive supranuclear palsy-Richardson’s syndrome (PSP-RS) patients, 17 Parkinson’s disease (PD) patients, and 30 healthy controls (HC). Comparative analysis revealed that PSP-RS patients…
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Transcriptional and cellular reprogramming in Anabaena sp. PCC7120 biofilms: implications for stress response
Cyanobacteria are major components of phototrophic biofilms, driving critical biogeochemical cycles and offering sustainable solutions for agriculture. However, the factors governing their transition from planktonic to sessile lifestyles remain poorly understood. Here, we investigated morphological…
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Targeting the US21 viroporin of human cytomegalovirus by calcium channel blockers as a new antiviral strategy
The Human cytomegalovirus (HCMV) US21 protein is a calcium-conducting viroporin that modulates intracellular Ca2+ homeostasis, safeguards cells from apoptosis, stimulates cell migration, and supports efficient HCMV replication. To validate pUS21 as a novel target for the identification of antiviral…
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Genomic and structural analysis of major antigenic proteins' variability in the human relapsing fever spirochete Borrelia persica
Antigenic variation enables immune evasion of pathogens, yet the mechanisms for the rapid change in their antigens without loss of structural and functional features are not fully known. Tick-borne relapsing fever (TBRF) spirochetes of the genus Borrelia can be used as a model because their…
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The iron-responsive transcription factor HapX drives iron starvation adaptation and virulence in Talaromyces marneffei
Talaromycosis is an opportunistic fungal infection caused by the thermally dimorphic fungus Talaromyces marneffei. During infection, T. marneffei survives within host phagocytic cells, where it encounters iron restriction and host-derived stress conditions. Therefore, regulation of iron homeostasis…
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Probiotic-driven microbiome remodeling is associated with coordinated immune and metabolic responses, improving growth and disease resistance in farmed tongue sole (Cynoglossus semilaevis)
In flatfish aquaculture, labour-intensive tank cleaning represents a major operational challenge, limiting sustainability due to its high labour requirements and associated costs. We tested a new semi-closed recirculating aquaculture system (RAS) protocol for Cynoglossus semilaevis (tongue sole)…