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The Lancet Microbe
Scopus
ISSN 2666-5247 · Elsevier · 357 artikel di indeks
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Artikel Jurnal
VRON-0200 alone and in combination with investigational antivirals for participants with chronic hepatitis B virus infection receiving stable nucleos(t)ide therapy: a phase 1b, randomised, open-label, multicentre trial
Summary: Background: Functional cure treatments for hepatitis B virus (HBV) have been restricted by their inability to restore anti-HBV immunity, often leading to viral rebound after treatment. VRON-0200 is a novel immunotherapy for functional cure of HBV that contains a checkpoint modifier…
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Artikel Jurnal
Accuracy of rapid diagnostic tests for Strongyloides stercoralis detection: a systematic review and meta-analysis
Summary: Background: Strongyloidiasis is a widely distributed, potentially fatal, neglected parasitic disease caused by the soil-transmitted helminth Strongyloides stercoralis. WHO has recently issued the target product profile (TPP) for new diagnostics to be deployed for public health control of…
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Artikel Jurnal
Diagnostics for priority bacterial pathogens: global gaps and research needs for curbing antimicrobial resistance in low-resource settings
Summary: Antimicrobial resistance (AMR) is a major and growing threat to global health, development, and security, with the greatest burden borne by low-income and middle-income countries (LMICs). Without urgent intervention, cumulative deaths between 2020 and 2050, attributable to AMR, are…
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Artikel Jurnal
Diversity analysis of indoor and outdoor fungal bioaerosols in UK households: a prospective, observational, longitudinal study
Summary: Background: Long-term exposure to indoor fungal bioaerosols is a recognised risk factor for respiratory illness, particularly in damp and poorly ventilated housing. However, the diversity and seasonal variability of these fungal communities are poorly understood. As part of the West London…
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Artikel Jurnal
Antimicrobial susceptibility patterns of Neisseria gonorrhoeae across anatomical sites within and between individuals in the Netherlands: a retrospective observational study
Summary: Background: Pharyngeal gonococcal infections are likely to contribute to the development of antimicrobial resistance (AMR) because of suboptimal efficacy of antibiotics in the pharynx, gene transfer with commensal Neisseria species, and the asymptomatic nature of pharyngeal infections…
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Artikel Jurnal
Regional and temporal trends in antimicrobial susceptibility among isolates from bacterial keratitis: a systematic review and meta-analysis
Summary: Background: Bacterial keratitis is an important cause of preventable vision loss worldwide. In this study, we aimed to synthesise the evidence for regional and temporal differences in antimicrobial resistance that could influence the choice of empirical therapy. Methods: For this…
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Artikel Jurnal
Upsurge of pneumococcal clade I-α/CC180 serotype 3 and its association with a LytA mutation linked to immune evasion and disease potential: an observational and experimental study
Summary: Background: Streptococcus pneumoniae serotype 3 is one of the most prevalent serotypes that cause invasive pneumococcal disease (IPD) in children and adults worldwide. Serotype 3 is associated with vaccine failures and breakthrough episodes in children vaccinated with 13-valent…
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Artikel Jurnal
The diagnostic void: how typhoid-by-default drives antimicrobial resistance in Ethiopia
Summary: The empirical diagnosis of typhoid-by-default represents a severe failure in Ethiopia’s management of febrile illnesses. This practice of diagnosing undifferentiated fever as typhoid without confirmation drives antimicrobial resistance (AMR) through a unique diagnostic ecosystem shaped by…
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Artikel Jurnal
Neonatal sepsis in Africa: what are we missing?
Summary: Neonatal sepsis remains one of the most pressing public health challenges in Africa, threatening progress towards the UN Sustainable Development Goal target 3.2 of reducing neonatal mortality to 12 deaths or less per 1000 livebirths. Beyond the well recognised barriers to diagnosis…