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Ophthalmology Science
Scopus
ISSN 2666-9145 · Elsevier · 825 artikel di indeks
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Artikel Jurnal
A Novel Multimodal Implementation of a Foundation Artificial Intelligence Model Using Optic Nerve Head Fundus Photographs and OCT Imaging for Glaucoma Detection
Purpose: To compare the performance of unimodal and multimodal implementation of the self-supervised learning model RETFound in detecting glaucoma using color fundus photographs (CFPs) and OCT images, and to assess its generalizability across different ethnicities, age groups, and disease…
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Artikel Jurnal
Deriving OCT-Equivalent Retinal Nerve Fiber Layer Thickness Maps from Fundus Photographs with Deep Learning Improves Glaucoma Diagnosis
Purpose: To develop and evaluate a deep learning model that predicts OCT-equivalent retinal nerve fiber layer thickness (RNFLT) maps directly from color fundus photographs and to assess their diagnostic value for detecting glaucomatous visual field (VF) loss. Design: Retrospective model development…
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Artikel Jurnal
Whole-Exome Sequencing in a Consanguinity-Enriched South Indian Retinitis Pigmentosa Cohort: Diagnostic Yield and Molecular Spectrum
Purpose: To determine the molecular diagnostic yield, variant spectrum, inheritance architecture, and influence of consanguinity on whole-exome sequencing outcomes in a South Indian retinitis pigmentosa (RP) cohort. Design: Prospective, registry-based cohort study. Subjects: A total of 113 affected…
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Artikel Jurnal
Randomized Study of Intravitreal Autologous CD34+ Stem Cells in Central Retinal Vein Occlusion (Treatment of Retinal vein occlusion Using STem cells [TRUST] Report 1): Safety and Feasibility
Purpose: To assess the safety and feasibility of intravitreal injection of autologous CD34+ bone marrow stem cells (BMSCs) in eyes with vision loss from central retinal vein occlusion (CRVO). Design: Phase I/II single-center, prospective, randomized, sham-controlled, double-masked study…
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Artikel Jurnal
Comparison of Deep Optic Nerve Head Structures and Optic Disc Morphology in Unilateral Peripapillary Intrachoroidal Cavitation
Purpose: To compare background characteristics, deep optic nerve head (ONH) structures, and optic disc morphology in participants with unilateral peripapillary intrachoroidal cavitation (PICC). Design: Retrospective cross-sectional study. Participants: One hundred six eyes of 53 participants with…
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Artikel Jurnal
Corneal Nerve Abnormalities in Chronic Central Serous Chorioretinopathy
Objective: Central serous chorioretinopathy (CSCR) is associated with abnormal neural regulation of choroidal blood flow and with systemic dysautonomia. Although choroidal neuropathy has been observed in rodent models of pachychoroid, its presence in human chronic CSCR remains unclear and difficult…
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Artikel Jurnal
Swept-Source OCT Angiography Features of Melanotic Choroidal Tumors: An Analysis of 102 Consecutive Cases
Purpose: To quantitatively analyze swept-source OCT angiography (SS-OCTA) features of choroidal melanoma and nevi, focusing on their distinguishing angiographic features. Design: Case-series study. Participants: This retrospective study included 102 consecutive patients with choroidal melanoma or…
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Artikel Jurnal
In-Context Learning for Data-Efficient Diabetic Retinopathy Detection via Multimodal Foundation Models
Objective: This study aims to evaluate whether in-context learning (ICL), a prompt-based learning mechanism enabling multimodal foundation models to rapidly adapt to new tasks without retraining or large annotated datasets, can achieve comparable diagnostic performance to domain-specific foundation…
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Artikel Jurnal
Evaluating Increment and Decrement Stimuli Responses in Patients with Glaucoma Using Virtual Reality–Based Perimetry
Objective: To evaluate increment and decrement stimuli responses in glaucoma using a virtual reality–based perimetric system, Vivid Vision Perimetry (VVP) and to compare these findings with conventional perimetry. Design: This is a cross-sectional study involving participants with diagnosed…
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Artikel Jurnal
Deep Learning Analysis of Widefield Cornea Endothelial Imaging in Fuchs Dystrophy
Purpose: To evaluate the use of a deep learning network (DLN) in analyzing widefield specular microscopy (WFSM) images in eyes with Fuchs endothelial corneal dystrophy (FECD). Design: Cross-sectional clinical observational study. Participants: A total of 1839 images were obtained via WFSM imaging…
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Artikel Jurnal
Topical WIN 55 212-2 Confers Long-Term Intraocular Pressure–Independent Neuroprotection in the DBA/2J Mouse Model of Glaucoma
Objective: To evaluate the neuroprotective efficacy of topical WIN 55 212-2 (WIN) in the DBA/2J mouse model of chronic glaucoma. Design: Preclinical controlled study. Subjects: Ninety 6-month-old DBA/2J mice (180 eyes) grouped in Untreated (UN), WIN 1%, or WIN 1% + rimonabant (RIM). Methods: In…
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Artikel Jurnal
Assessing the Relationship between Foveal Cone Density, Outer Nuclear Layer Thickness and Foveal Morphology
Purpose: To assess the relationship between foveal cone topography, foveal outer nuclear layer (ONL) thickness, foveal morphology, and foveal avascular zone (FAZ) area in individuals with normal vision. Design: Retrospective cross-sectional study. Participants: A total of 68 participants with…
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Artikel Jurnal
Association of Physical Frailty and Genetic Predisposition with Risk of Irreversible Eye Diseases
Objective: The evidence linking frailty to overall and specific irreversible eye diseases is limited. Moreover, it is unclear whether frailty is associated with similar increased risk across individuals with different genetic risk profiles. The aim of this study was to examine the association…
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Artikel Jurnal
Assessing the Impact of Pharmacological Pupil Dilation on Anterior Chamber Cells Counting Using OCT
Purpose: Anterior chamber (AC) cells are seen as hyperreflective dots (HRDs) on anterior segment OCT (AS-OCT), but many factors can affect their objective counting. The aim of this study was to evaluate the effect of pharmacological dilation with tropicamide 0.5% (T) or phenylephrine 2.5% +…
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Artikel Jurnal
OCT-Derived Quantitative Measurement of Extent of Vascularization (“Zone”) in Retinopathy of Prematurity
Purpose: To provide a quantitative approach to the measurement of zone in retinopathy of prematurity (ROP) using ultra-widefield OCT (UWF-OCT). Design: Diagnostic accuracy study. Subjects: Infants undergoing ROP screening at Oregon Health Science University between June 2023 and October 2024, whose…
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Artikel Jurnal
Retinal and Choroidal Microvasculature at Different Myopia Severities: A Systematic Review and Meta-Analysis
Topic: This study systematically evaluates changes in retinal and choroidal microvasculature with increasing myopia severity. Clinical Relevance: Conflicting results in reported studies on the changes in retinal and choroidal microvasculature with increasing myopia severity require comprehensive…
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Artikel Jurnal
Can a Natural Image-Based Foundation Model Outperform a Retina-Specific Model in Detecting Ocular and Systemic Diseases?
Purpose: DINOv2 is a natural image-based foundation model (FM), pretrained exclusively on 142 million natural images from the LVD-142M data set. In contrast, RETFound is a retina-specific FM, pretrained on ∼3 million images, including natural images, color fundus photos, and OCT images (∼1 million…
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Artikel Jurnal
Validation of an Artificial Intelligence–Based Anterior Chamber Depth Estimation Using a Smartphone-Compatible Slit Lamp Device
Purpose: Accurate evaluation of anterior chamber depth (ACD), a major risk factor for angle closure, is clinically important. Although standard techniques provide reliable measurements, they are often labor-intensive, technically demanding, and time-consuming. To address this, we previously…
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Artikel Jurnal
Caffeine Therapy Reduces Severe Retinopathy of Prematurity in Neonates with Gestational Age between 23 and 28 Weeks
Purpose: To investigate the association of caffeine citrate therapy with the onset and exacerbation of retinopathy of prematurity (ROP). Design: A retrospective observational cohort study. Participants: Preterm neonates born at Hyogo Prefectural Amagasaki General Medical Center between January 2018…
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Artikel Jurnal
Association between Choroidal Vascular Hyperpermeability and Vortex Vein Anastomoses in Central Serous Chorioretinopathy
Purpose: To investigate the association between choroidal vascular hyperpermeability (CVH) and vortex vein anastomoses in the macula of patients with central serous chorioretinopathy (CSC). Design: A retrospective comparative study. Subjects: A total of 118 eyes of 106 patients with CSC. Methods…