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Phytomedicine Plus
Scopus
ISSN 2667-0313 · Elsevier · 985 articles in the index
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Journal Article
8β-hydroxy-9(11),13-abietadien-12-one and margolone ameliorate intestinal epithelial barrier dysfunction via aryl hydrocarbon receptor activation in a Caco-2 monolayer model
Background: Disrupting the intestinal epithelial barrier function causes several diseases, including inflammatory bowel disease (IBD). Indole metabolite 6-formylindolo[3,2-b]carbazole (FICZ) has been reported to ameliorate this disruption by activating the aryl hydrocarbon receptor (AhR). We…
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Journal Article
Phytochemicals in breast cancer therapy: Decoding molecular pathways and pioneering therapeutic strategies
Background: Breast cancer constitutes a global health crisis, affecting millions worldwide and contributing significantly to cancer-related mortality. Its development, progression, and persistence are driven by complex molecular signaling networks, including the PI3K/Akt/mTOR, MAPK/ERK, NF-κB, TNF…
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Journal Article
Azadirachta indica extract alleviates the progression of cholangiocarcinoma in liver fluke-infected hamsters
Background: Cholangiocarcinoma (CCA) caused by chronic infection with the liver fluke Opisthorchis viverrini (O. viverrini), a common and prevalent cancer in Southeast Asia, including Northeast Thailand has limited preventive options. Neem (Azadirachta indica) leaf extract possesses…
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Journal Article
The hypoglycemic and hypolipidemic effects of Olea europaea L. leaves on fructose-induced diabetic wistar rats
Type 2 Diabetes mellitus is a chronic disorder of carbohydrates, protein and lipid metabolism ending up with serious complications such retinopathy, nephropathy and neuropathy. Olea europaea L. leaves are extensively used worldwide in conventional medicine of several diseases, especially Diabetes…
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Journal Article
Chang'an II Recipe alleviates visceral hypersensitivity in IBS-D rats by inhibiting mast cell activation through the AhR-Notch1 pathway
Background: Irritable bowel syndrome with diarrhea (IBS-D) is a common functional gastrointestinal disorder. It is often accompanied by anxiety and depression, and severely impacts patients' quality of life. Visceral hypersensitivity is closely associated with the pathogenesis of IBS-D, potentially…
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Journal Article
Therapeutic effects of Biochanin A against CCl4-induced cardiac toxicity: enhancing antioxidant defenses and modulating inflammatory responses
Background: Cardiovascular damage caused by environmental toxins, such as carbon tetrachloride (CCl4), is closely associated with oxidative stress and inflammatory injury. Biochanin A, an isoflavone isolated from Trifolium pratense L., has been demonstrated to be a prospective candidate in rational…
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Journal Article
Efficacy of Moringa oleifera leaves extracts as a natural treatment for marine parasite and bacterial pathogens
Background: Pathogens such as bacteria and parasites are major contributors to losses in aquaculture production. Chemical treatments were commonly used; however, they can have hazardous effects on humans, other animals, and the environment. Purpose: Therefore, there is a demand for safe treatment…
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Journal Article
Effects of Moringa Oleifera leaf extract on glycemic control and inflammation in metabolic syndrome: a randomized controlled trial
Background: The present double-blind, randomized, placebo-controlled clinical trial aimed to evaluate the effects of Moringa oleifera (MO) extract, a natural source of polyphenols, on glycemic control and inflammatory markers in patients with metabolic syndrome (MetS). Methods: Totally 73 MetS…
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Journal Article
Deltan polyherbal formula offers multifaceted protection against cardiometabolic syndrome via metabolic and microbiome rebalancing
Objective: Cardiometabolic syndrome (CMS) increases risks for type 2 diabetes and cardiovascular disease. Although individual herbal extracts such as Panax ginseng, Panax notoginseng, and Salvia miltiorrhiza have demonstrated metabolic and cardiovascular benefits, their combined synergistic actions…
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Journal Article
Understanding cytotoxic effects of traditional herbal remedies: A comprehensive review
Introduction: Traditional herbal products have long been integral to healthcare systems worldwide, providing therapeutic benefits in various cultural practices. However, concerns regarding the cytotoxicity of these products, often overlooked, present significant safety risks, especially with the…
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Journal Article
Modulation of apoptotic pathways and epithelial–mesenchymal transition in HeLa cervical cancer cells by Ficus deltoidea-silver nanoparticles (FD-AgNPs)
Cervical cancer, primarily caused by persistent Human Papillomavirus (HPV) infection, is a leading cause of cancer-related mortality due to its propensity for resistance and metastasis. Ficus deltoidea, a medicinal plant rich in flavonoids and polyphenols, has demonstrated promising anticancer…
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Journal Article
A comprehensive review on Kaempferol as a therapeutic flavonoid against ESKAPE and multiple drug-resistant bacteria: Recent advances and challenges
The emergence of multidrug-resistant (MDR) bacteria, particularly the ESKAPE pathogens (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter species), is considered as major threat to global public health. Kaempferol…
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Journal Article
Antispasmodic and antidiarrheal activity of cannabidiol (CBD): involvement of K⁺ channels in intestinal smooth muscle
Background: Functional gastrointestinal disorders, such as irritable bowel syndrome and colitis, are highly prevalent and often poorly responsive to conventional therapies. Cannabidiol (CBD), a non-psychoactive phytocannabinoid, has been reported to modulate intestinal motility. Purpose: To…
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Journal Article
Unlocking the phytochemical and pharmacological potential of Ocimum sanctum L. and Plectranthus amboinicus (Lour.) Spreng. toward developing novel evidence-based herbal products in Sri Lanka: A comprehensive review
Ocimum sanctum L. (Heen Maduruthala) and Plectranthus amboinicus (Lour.) Spreng. (Kapparawalliya) are two highly abundant medicinal plants belonging to the family Lamiaceae. Despite their widespread availability and documented ethnomedicinal uses, their phytopharmacological potential remains…
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Journal Article
Kratom syrup reduces colitis severity and enhances intestinal barrier integrity in acetic acid-induced colitis mice
Introduction: Kratom (Mitragyna speciosa) is traditionally used in Thailand for its anti-diarrheal effects, yet its potential in colitis therapy remained unexplored. This study evaluated the therapeutic efficacy of kratom syrup (KS) containing kratom extract in an acetic acid-induced colitis mouse…
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Journal Article
Excavation and validation of the active components and mechanisms of longan against colorectal cancer
Backgound: Colorectal cancer (CRC) is the fourth most common malignant tumor worldwide and remains a leading cause of cancer-related mortality. Dimocarpus longan Lour., a member of the Dimocarpus genus in the Sapindaceae family, has been traditionally used as a tonic to alleviate deficiencies and…
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Journal Article
Genus Aerides, Coelogyne and Eria: A comprehensive review of ethnopharmacology, phytochemistry, and pharmacology
The Orchidaceae family includes several medicinally important genera, particularly Aerides, Coelogyne, and Eria, which hold a prominent place in Southeast Asian traditional medicine for managing infectious, inflammatory, metabolic, and degenerative diseases. This review systematically compiles…
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Journal Article
Biological effects of curcuminoids and homoleptic metal complexes of curcuminoids against non-tumoral astrocytic and glioblastoma cell lines
Curcumin, a compound that has sparked global interest, has been extensively studied for its potent cytotoxic effects on various human tumoral cell lines. Furthermore, it’s structurally related curcuminoids have shown even greater cytotoxicity against glioblastoma cell lines. In this study, we…
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Journal Article
A comprehensive review on role of phytoconstituents from the roots of Asparagus racemosus (Queen of Herbs)
Asparagus racemosus, commonly known as Shatavari or the ''Queen of Herbs,'' is a traditional medicinal plant mentioned in Ayurveda, is renowned for its therapeutic potential which is attributed to its roots. Roots of Asparagus racemosus consists of a rich array of bioactive phytochemicals such as…
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Journal Article
The Chinese ancient prescription Zhentonggufang alleviates pain and inflammation, which is associated with reduced levels of inflammatory cytokines IL-6 and IL-1β
Background: Chronic pain poses serious health and socioeconomic burdens, highlighting the urgent need for safer, more effective analgesic alternatives from natural sources. Objective: This study aimed to explore the analgesic and anti-inflammatory potential and mechanisms of Zhentonggufang (ZTGF)…