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Atherosclerosis Plus
Scopus
ISSN 2667-0895 · Elsevier · 269 artikel di indeks
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Artikel Jurnal
Passive E06 IgG reduces lesional PC-OxPL and macrophage accumulation in cholesterol-fed Ldlr
Background: Oxidized phospholipids (OxPL) promote vascular inflammation and atherosclerosis. Although transgenic expression of the E06 single-chain antibody reduces atherosclerosis in mice, the therapeutic potential and mechanism of passive immunization with full-length recombinant E06 IgG remain…
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Artikel Jurnal
The association between albuminuria and coronary atherosclerotic burden in the general population
Background: Albuminuria predicts cardiovascular events, but its association with prevalent subclinical coronary atherosclerosis is less well defined. We examined the cross-sectional relationship between urinary albumin–creatinine ratio (UACR) and coronary atherosclerotic burden in middle-aged…
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Real-world cardiovascular risk estimation, blood pressure and LDL-cholesterol control: Two epidemiological studies in Romania, during pandemic and post-pandemic (SNAPSHOT-Romania)
Background and aims: Data on estimation of cardiovascular (CV) risk by physicians and perceptions of hypertension and dyslipidemia control are lacking in Eastern Europe. Therefore, in patients with hypertension and dyslipidemia, during the COVID-19 pandemic and post-pandemic periods, we compared CV…
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Associations between carotid macrovascular and retinal microvascular alterations in diabetes: Evidence synthesis and implications for risk assessment
Diabetes mellitus is characterized by progressive vascular injury affecting both the microcirculation and large arteries. Diabetic retinopathy is a major microvascular complication and has been associated in observational studies with several carotid vascular phenotypes, including increased carotid…
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Sex differences and gender-related factors in the management and perception of LDL-cholesterol in ASCVD: Real-Life evidence from the EPHESUS registry in cardiology practice
Aims: Atherosclerotic cardiovascular disease (ASCVD) remains the leading cause of morbidity and mortality globally. While it impacts both sexes, women are frequently underdiagnosed and undertreated, particularly in lipid management. This study aimed to evaluate sex differences, and the…
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Putative protective role of
Background: Familial hypercholesterolemia (FH) is most frequently caused by pathogenic variants in LDLR , but phenotypic variability suggests the influence of genetic modifiers. Methods: We investigated a large multigenerational family with FH, combining clinical data, lipid profiles, and genetic…
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Association of lipoprotein(a) with the angiographic extent of coronary artery disease and selected angiographic findings in patients with acute coronary syndromes
Background: The aim of this study was to investigate the association of serum lipoprotein(a) [Lp(a)] concentrations with the angiographic extent of coronary artery disease and selected angiographic findings in patients hospitalized with acute coronary syndromes (ACS). Methods: This retrospective…
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Associations of long-term vitamin K antagonist and direct oral anticoagulant therapies with progression of coronary artery calcification: A Danish population-based study
Aims: Vitamin K antagonists (VKAs) may promote vascular calcification through inhibition of vitamin K-dependent proteins. We aimed to examine the association between long-term anticoagulant therapy with VKA or direct oral anticoagulants (DOACs) and progression of coronary artery calcification (CAC)…
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Microbial mechanisms in atherosclerosis: Revisiting the infectious hypothesis
Atherosclerosis is traditionally viewed as a lipid-driven inflammatory disease; however, this model does not fully explain acute coronary events arising from non-obstructive lesions or the persistence of residual cardiovascular risk despite lipid-lowering therapy. Emerging evidence implicates…
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Effects of evolocumab on plasma coenzyme Q10 in patients with heterozygous familial hypercholesterolemia
Background and aims: Muscle symptoms are common with statin therapy, and reduced plasma coenzyme Q10 (CoQ10) has been proposed as a potential mechanism. Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors are widely used in patients with statin intolerance or severe…
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Artikel Jurnal
Cholesterol in amyotrophic lateral sclerosis: a bystander, a biomarker, or a target?
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by progressive motor neuron loss. In addition to the different pathogenic mechanisms, in recent years, increasing attention has been directed toward the role of lipid metabolism in ALS pathogenesis, although the…
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LDL-cholesterol distance to target: A practical tool for guiding lipid-lowering treatment decisions
Low-density lipoprotein cholesterol (LDL-C) is causal in atherosclerotic cardiovascular disease (ASCVD), still the leading causes of global morbidity and mortality. The 2025 update of the ESC/EAS guidelines for the management of dyslipidemia recommends increasingly stringent, risk-based LDL-C…
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Lipoprotein metabolism and inflammation in healthy young subjects – exploring the postprandial and postabsorptive phases following intake of a standardized meal
Background and aims: Commonly measured cardiometabolic biomarkers have not been systematically characterized across the long-term continuum of the postprandial and postabsorptive phases. The aim of the present study was to evaluate how the exact time since last meal impacts test results for…
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Retinal findings in familial hypercholesterolemia: An exploratory case-control study
Background and aims: Patients with familial hypercholesterolemia (FH) have elevated LDL-C levels from birth and increased risk of cardiovascular disease due to atherosclerosis, mostly affecting larger arteries. Less is known about effects of elevated LDL-cholesterol on smaller arteries. Retinal…
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Association of the C-reactive protein-triglyceride-glucose index (CTI) with lower-extremity peripheral artery disease among U.S. adults
Introduction: Peripheral artery disease (PAD) is a common yet underrecognized consequence of systemic atherosclerosis, affecting over 200 million adults worldwide and one in five older adults in the United States. PAD carries substantial morbidity, increasing the risk of major cardiovascular and…
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Expert consensus on Lipoprotein(a) in the Gulf countries: Navigating cardiovascular risk and therapeutic advances
Background: Lipoprotein(a) [Lp(a)] is increasingly recognized as an independent and causal risk factor for atherosclerotic cardiovascular (CV) disease including aortic valve stenosis, myocardial infarction, stroke, peripheral arterial disease and CV death. Despite growing global awareness…
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Awareness and perceptions of systemic inflammation in atherosclerotic cardiovascular disease and chronic kidney disease: The SPARK-CVD China survey
Background and aims: Cardiovascular disease (CVD) remains a leading cause of death in China. Systemic inflammation (SI) is an emerging risk factor in atherosclerotic CVD (ASCVD) and chronic kidney disease (CKD). High-sensitivity C-reactive protein (hsCRP) is increasingly recognised for…
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Parallel screening strategies reveal distinct phenotypic and genotypic profiles of familial hypercholesterolemia in children and adults
Background: Multiple familial hypercholesterolemia (FH) screening strategies are recommended, but how they work together within a population remains poorly understood. Here, we aimed to compare the characteristics of children diagnosed through a universal screening program with those of adults…
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Environmental pollution, apolipoprotein A-1 autoantibodies and cardiovascular risk: evidence from a geospatial cross-sectional study
Aims: Autoantibodies against apolipoprotein A-1 (AAA1) are independent cardiovascular risk factor in the general population. Genetic factors and viral infections have been linked to AAA1 occurrence. We studied the association between environmental pollution and AAA1 response and their relationship…
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Sex-specific associations of the triglyceride-glucose index with systemic inflammation and arterial stiffness in adults with normal glucose and triglyceride levels
Background: The triglyceride-glucose (TyG) index is a surrogate marker of insulin resistance. However, its clinical relevance in individuals with strictly normal fasting glucose and triglyceride levels remains unclear. We aimed to investigate the sex-specific associations of the TyG index with…