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Advances in Redox Research
Scopus
ISSN 2667-1379 · Elsevier · 174 artikel di indeks
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Artikel Jurnal
Mechanisms, challenges, and translational perspectives of cold atmospheric plasma in cancer and wound healing
Cold atmospheric plasma (CAP) generates reactive species at low temperatures, and it has shown promise in oncology, wound healing, and regenerative medicine. Therapeutic mechanisms and translational potential remain unclear across a wide range of biological applications. In this article, a…
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Inhibition of smooth muscle phenotypic modulation by bardoxolone methyl, omaveloxolone, and cinnamaldehyde is Nrf-2 dependent
Neointimal hyperplasia (NH) is a primary cause of arterial restenosis following angioplasty, driven by oxidative stress and vascular smooth muscle cell (VSMC) phenotypic modulation. This study investigated whether the class I electrophilic Nrf2 activators Bardoxolone methyl (BAR), Omaveloxolone…
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Evaluation of salivary total antioxidant capacity in cigarette smokers versus water pipe smokers among dental students in Sulaimani city
Background: Tobacco use, whether through cigarettes or waterpipes, has been associated with the development of oxidative stress and a reduction in antioxidant defense. There is dearth of information on the impact of smoking frequency and duration among individuals of close age brackets. This study…
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Mitochondria at the frontline of environmental toxicity in conflict and crisis zones: mechanisms, models, and countermeasures
Populations exposed to conflict and crisis zones - including military personnel, first responders, and civilians - face complex environmental stressors such as combustion-derived irritants, engineered nanoparticles, and ionizing radiation. Mitochondria, as central regulators of cellular…
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Artikel Jurnal
Intercellular propagation of ferroptosis
Ferroptosis, an iron-dependent form of regulated cell death driven by lipid peroxidation, was initially characterized as a cell-autonomous process. However, emerging evidence demonstrates that ferroptotic signals can propagate between cells, triggering synchronized death events with significant…
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Artikel Jurnal
Ferroptosis in gut pathophysiology: Molecular mechanisms and microbial regulation of iron metabolism and oxidative stress
Ferroptosis, an iron-dependent form of regulated cell death driven by lipid peroxidation and oxidative stress, plays a pivotal role in intestinal pathophysiology. As the main site for iron absorption and a crucial barrier against environmental challenges, the intestinal epithelium is particularly…
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Targeting the AGE-RAGE axis in acute lung injury: Mechanistic insights and redox-modulatory strategies
Acute Respiratory Distress Syndrome (ARDS) is a serious respiratory condition characterized by a rapid onset of severe inflammation in the lungs. This inflammation results from various causes. The syndrome is marked by widespread damage to the alveolar epithelial cells and capillary endothelial…
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Artikel Jurnal
Influence of pteridines and statins on cancer: A therapeutic strategy targeting nitric oxide synthase (NOS) pathway
A family of enzymes known as nitric oxide synthases (NOS) produces nitric oxide (NO), a tiny, unstable, and potentially hazardous gas that is highly diffusible across cell membranes. NO and NO metabolites, such as nitrite, nitrate, S-nitrosothiols, nitrosamines, and peroxynitrite, mediate a variety…
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The effect of atorvastatin on inflammatory markers, lipid profile, and renal function in kidney diseases: a systematic review and meta-analysis of randomized controlled trials
Background: Chronic and acute kidney disorders (CKD, AKI) afflict millions globally, leading to increased morbidity and death, especially from cardiovascular consequences. Atorvastatin, a popular statin, offers lipid-lowering, anti-inflammatory, and antioxidant qualities that may assist kidney…
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Artikel Jurnal
Role of L-carnitine in exercise training: Anti-inflammatory, antioxidant, and metabolic interactions
L-carnitine is a mitochondria-targeted compound that plays a pivotal role in lipid metabolism, redox balance, and inflammatory regulation, particularly under conditions of elevated metabolic demands such as exercise. This review explores the multifaceted functions of L-carnitine in modulating…
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Artikel Jurnal
A concise review on health benefits of alkaline reduced water
Alkaline reduced water (ARW), produced through electrolysis, has emerged as a health-promoting beverage due to its elevated pH and reduced oxidation–reduction potential (ORP). This type of water offers several notable health benefits. ARW effectively neutralizes excess body acidity, promoting a…
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EROS protein: Decoding its pivotal role in redox homeostasis and disease pathogenesis
The Essential for Reactive Oxygen Species (EROS) protein, a critical molecular chaperone for NADPH oxidase 2 (NOX2/gp91phox), has emerged as a central regulator of redox signaling and immune defense. Recent structural and functional studies reveal that EROS orchestrates NOX2 maturation, prevents…
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Artikel Jurnal
Methylglyoxal in cancer: Bidirectional regulatory networks and precision intervention—From metabolic reprogramming to cross-disease synergistic targeting
Methylglyoxal (MG), a core byproduct of glycolysis, exerts a dual role in cancer via a ''dose-dependent hormesis effect''. At low concentrations, it promotes tumor proliferation and metastasis by regulating polyamine metabolism, epigenetic modifications, and the immune microenvironment. In…
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Association of CYP8B1 rs3732860 polymorphism and gene expression with oxidative stress and biochemical markers in Type 2 diabetes mellitus
Background: Type 2 diabetes mellitus (T2DM) is a multifactorial metabolic disorder characterized by chronic hyperglycemia, oxidative stress, and low-grade inflammation. The CYP8B1 gene, a key regulator of bile acid synthesis and hepatic metabolism, may be influenced by oxidative status and has…
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Artikel Jurnal
Protective effects of oral α-pinene pretreatment against acetic acid-induced colitis in rats: effects on oxidative stress and Nrf2, HO-1, and NQO1 mRNA expression
Background: Colitis is a chronic inflammatory disorder associated with excessive oxidative stress and inflammatory responses. This study aimed to evaluate the protective effects of alpha-pinene pretreatment against acute acetic acid (AA)-induced colitis in rats. Methods: Forty male Wistar rats were…
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Artikel Jurnal
Intracellular polyphosphate as a cell-intrinsic regulator of metabolism, inflammation, and thromboinflammation
Inorganic polyphosphate (polyP) is a conserved linear polymer of orthophosphate units with emerging roles in mammalian cell biology. While extracellular platelet-derived polyP is well established as an enhancer of coagulation, inflammation, and thromboinflammation, the intracellular functions of…
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Cadmium telluride quantum dots have emerged as versatile nanomaterials for constructing highly sensitive analytical platforms for trace contaminant detection
Cadmium telluride (CdTe) quantum dots have emerged as versatile nanomaterials for constructing highly sensitive analytical platforms for trace contaminant detection. Their unique size-dependent electronic structure, tunable surface chemistry, and compatibility with hybrid interfaces enable diverse…
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Integrated Proteomics Reveals the Role of EPO-HBB Regulatory Axis in Lung Remodelling During Chronic Hypoxia Followed by De-Induction
Chronic hypoxia dysregulates pulmonary, vascular, and metabolic pathways. Most high-altitude studies primarily focus on acute exposure responses, while the molecular events governing de-induction after prolonged hypoxic stress are comparatively unexplored. Understanding chronic hypoxia-induced…
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Artikel Jurnal
Metabolic responses to O-GlcNAcase inhibition in App
Antibodies against β-amyloid (Aβ) show promise in the treatment of Alzheimer’s disease (AD), creating opportunities for combination therapies. Protein O-GlcNAcylation is altered in human AD and animal models, but clinical O-GlcNAcase (OGA) inhibition has reduced p-tau without providing cognitive…
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Artikel Jurnal
Mitochondrial ferroptosis in cardiovascular diseases: Mechanisms, biomarkers, and therapeutic opportunities — A narrative review
Background: cardiovascular diseases (CVDs) are propelled by mitochondrial ferroptosis, an iron-dependent cell death involving ROS-driven lipid peroxidation, with mitochondria as key regulators via dynamics, iron flux, and antioxidant defences like GPX4/NRF2. Objectives: To delineate mitochondrial…