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Pharmacological Research - Modern Chinese Medicine
Scopus
ISSN 2667-1425 · Elsevier · 804 artikel di indeks
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Artikel Jurnal
Effect of Lǜchá (绿茶) on oxidative stress and inflammatory responses: A systematic review of human and animal studies across exercise and non-exercise models
Introduction: While studies suggest that exercise is beneficial for health, they also indicate that it can trigger an increase in oxidative stress and inflammation, leading to muscle soreness and tissue damage. This study aims to comprehensively examine the effects of Lǜchá in alleviating oxidative…
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Artikel Jurnal
GC-MS, quantitative phytochemical estimation and biological activities of the leaf and root extracts of Ficus racemosa L․
Introduction: Ficus racemosa L. (Jù guǒ róng) is a traditionally used medicinal plant in the management of various ailments, including diabetes, dysentery, bilious affections, diarrhea, etc. The present study aimed to comparatively evaluate the phytochemical constituents and biological activities…
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Artikel Jurnal
Bioactive phytochemicals modulating skin depigmentation, inflammation and cardiovascular pathways
Introduction: Vitiligo (leukoderma) is a chronic autoimmune disorder characterized by selective melanocyte loss, resulting in depigmented skin patches. Its pathogenesis involves genetic susceptibility, immune-mediated melanocyte destruction, oxidative stress, neurological factors and chronic…
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Artikel Jurnal
Component identification and ameliorative effect of amyloid-β-induced toxicity in transgenic Caenorhabditis elegans of Ershiwuwei Zhenzhu pills
Introduction: Alzheimer’s disease (AD) is the most common form of dementia which burdens patients’ family and society heavily. However, no effective cure for AD was proposed. Ershiwuwei Zhenzhu pills (EZP) is a kind of traditional Tibetan medicine formulation with a wide range of clinical uses. An…
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Artikel Jurnal
Phytochemical profiling of Ocimum sanctum L. varieties and prediction of rosmarinic acid as a chemical marker for dermatological applications via in silico approaches
Introduction: Ocimum sanctum L. (Sheng Luo Le) is utilized in Traditional Chinese Medicine (TCM) for clearing heat and treating skin infections. However, the chemical heterogeneity between the white and red varieties complicates quality standardization and the prediction of therapeutic efficacy…
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Artikel Jurnal
Bioactivity-guided metabolite profiling of Pistacia chinensis Bunge gall using LC–HRMS/MS
Introduction: Pistacia chinensis Bunge (Chinese pistache) is native to central and southern China, Nepal, and East Asia, where it grows in mountain forests and valleys under warm temperate conditions. In traditional Chinese medicine, it is used to treat dysentery, inflammatory disorders, psoriasis…
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Artikel Jurnal
Unveiling the molecular mechanisms of Zhuang medicine in liver cancer treatment: From Active ingredient screening to diosgenin-mediated targeted regulation
Background: Zhuang medicine has long been used for the clinical management of liver cancer (LC); however, its underlying therapeutic mechanisms remain largely unelucidated. This study aimed to identify bioactive compounds within Zhuang medicine formulations and investigate their potential…
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Artikel Jurnal
6-Shogaol enhances the chemotherapeutic efficacy of 5-fluorouracil through apoptosis induction and cell cycle arrest in MCF-7 breast cancer cells
Background: Ginger (Zingiber officinale) has a long history of use in Traditional Chinese Medicine (TCM) as a “cure-all remedy”. 6-Shogaol, an essential bioactive element from dried ginger, has been widely used in traditional Chinese medicinal preparations. 6-Shogaol has been reported to exhibit…
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Artikel Jurnal
Effects of Chinese herbal medicine on reducing steroid-induced adverse reactions: A systematic review and meta-analysis from 1651 autoimmune disease patients in 18 randomized controlled trials
Introduction: : Steroid-induced adverse reactions present significant challenges in the treatment of autoimmune diseases. Chinese herbal medicine, especially yin-nourishing formulations, shows potential for managing these adverse reactions. The objective of this review is to evaluate the…
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Artikel Jurnal
Restoring ovarian function in PCOS: Ethanol extract of Alocasia indica tuber attenuates hormonal imbalance, oxidative stress, and cystic follicles in a letrozole-induced rat model
Introduction: Alocasia indica, synonymous with Alocasia macrorrhizos (Araceae), corresponds botanically to the species documented in the Traditional Chinese Medicine (TCM) pharmacopeia, where A. macrorrhizos—referred to as Hai Yu—is commonly found throughout southern China. In TCM literature, A…
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Artikel Jurnal
Harnessing Clerodendrum serratum and its Nanoformulations: A tri-modal evaluation for improved anti-inflammatory, analgesic, and antioxidant activities
Aim of the study: The aim of this study was to evaluate the anti-inflammatory, analgesic and antioxidant activities of Clerodendrum serratum extract (CSE), its silver nanoparticles (AgNPs), and PEGylated nanoparticles (PEG-AgNPs) using in vivo, and in silico approaches. Material and methods: Acute…
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Artikel Jurnal
Research progress on the mechanism of Buyang Huanwu decoction in treating ischemic cardio-cerebrovascular diseases
Introduction: Buyang Huanwu Decoction (BYHWD), a classic TCM formula for Qi deficiency and blood stasis, improves the clinical prognosis of ischemic cardio-cerebrovascular diseases. This review synthesizes evidence on its pharmacological mechanisms, aiming to elucidate the scientific basis of…
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Artikel Jurnal
Unveiling the therapeutic mechanisms of Yuehua Pill against multidrug-resistant tuberculosis via network pharmacology and molecular docking
Introduction: Multidrug-resistant tuberculosis (MDR-TB) presents a severe global health challenge due to limited treatment options. Yuehua Pill, a traditional Chinese medicine formula, has shown clinical efficacy as an adjunctive therapy. However, its molecular mechanisms remain unclear. This study…
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Artikel Jurnal
Yishen Quzhuo decoction improve chronic kidney disease by regulating amino acid metabolism: An experimental validation guided by network pharmacology
Introduction: YiShen QuZhuo Decoction (YSQZD) is a clinically proven traditional Chinese medicine formula for chronic kidney disease (CKD), but its underlying mechanism lacks systematic investigation. CKD is a prevalent renal disorder with limited effective treatments, and traditional herbal…
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Artikel Jurnal
Research progress on the treatment of inflammatory bowel disease by traditional Chinese medicine
Introduction: Inflammatory bowel disease (IBD), encompassing ulcerative colitis (UC) and Crohn's disease (CD), represents a growing global health challenge. This is particularly evident in China, where incidence rates have risen rapidly. Grounded in holistic principles, traditional Chinese medicine…
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Artikel Jurnal
Exploring the mechanism of drug induced liver injury and the regulatory role of traditional Chinese medicine in related signaling pathways
Objectives: Drug-induced liver injury (DILI) is a significant clinical challenge. This review explores the molecular mechanisms involved in DILI and examines the role of TCM in regulating key signaling pathways such as JNK, Nrf2, NF-κB, PPAR, SIRT1, Bcl-2/Bax, and AMPK. The aim is to determine how…
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Artikel Jurnal
Machine learning framework for multi-regulatory safety assessment of traditional Chinese medicine compounds
Introduction: Traditional Chinese Medicine faces unprecedented regulatory challenges due to multi-component complexity incompatible with conventional single-molecule assessment frameworks, necessitating innovative computational approaches for cross-jurisdictional safety and efficacy evaluation…
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Artikel Jurnal
Data mining-based investigation of the compatibility principles of Astragali Radix-containing in cardiovascular formulas
Introduction: Cardiovascular disease (CVD) is a major global health challenge. As a key herb for replenishing qi, Astragali Radix (Huangqi) is widely used in traditional Chinese medicine (TCM) prescriptions for treating cardiovascular conditions. This study systematically investigated the…